DE702729C - Process for the production of calcium gluconate - Google Patents

Process for the production of calcium gluconate

Info

Publication number
DE702729C
DE702729C DE1939B0186266 DEB0186266D DE702729C DE 702729 C DE702729 C DE 702729C DE 1939B0186266 DE1939B0186266 DE 1939B0186266 DE B0186266 D DEB0186266 D DE B0186266D DE 702729 C DE702729 C DE 702729C
Authority
DE
Germany
Prior art keywords
gluconate
production
calcium
calcium gluconate
alkali metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1939B0186266
Other languages
German (de)
Inventor
Dr Max Busch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAX BUSCH DR
Original Assignee
MAX BUSCH DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAX BUSCH DR filed Critical MAX BUSCH DR
Priority to DE1939B0186266 priority Critical patent/DE702729C/en
Application granted granted Critical
Publication of DE702729C publication Critical patent/DE702729C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung von Calcium?lukonat Durch Untersuchungen ist festgestellt worden, daß bei der katalytischen Dehydrierung von Traubenzucker in alkalischer Lösung bei Gegenwart von Palladium auf Calciumcarbonat als Träger mit Sauerstoff als Wasserstoffacceptor ein Gemisch von Säuren entsteht, von denen die Mesoweinsäure als solche erkannt und abgetrennt werden konnte (vgl. Franz Zirkelbach, Zur katalytischen Dehydrierung der Alkohole, Dissertation, Erlangen, 1936, S. 17, 18 und 44).Process for the preparation of calcium luconate By research it has been found that in the catalytic dehydrogenation of grape sugar in alkaline solution in the presence of palladium on calcium carbonate as a carrier with oxygen as the hydrogen acceptor, a mixture of acids is formed, one of which the mesotartaric acid could be recognized as such and separated (cf. Franz Zirkelbach, On the catalytic dehydrogenation of alcohols, dissertation, Erlangen, 1936, p. 17, 18 and 44).

Neuerdings wurde nun gefunden, daß der in Frage stehende Dehydrierungsvorgang sich so leiten läßt, daß er sich auf die Aldehydgruppe beschränkt und somit ausschließlich die pharmazeutisch wertvolle Glukonsäure erhalten wird. Dies wird dadurch erreicht, daß man d-Glukose und Alkalilauge bei dem erwähnten bekannten Verfahren in äquimolekularen Mengen anwendet. Die Behandlung ist zu beenden, sobald das Alkalihydroxy'd für die Bildung des Alkaliglukonats verbraucht ist. Das Ende der Umsetzung ist äußerlich daran zu erkennen, daß die lebhafte Sauerstoffaufnahme nur noch in geringem Maße erfolgt.It has recently been found that the dehydration process in question can be guided in such a way that he is restricted to the aldehyde group and thus exclusively the pharmaceutically valuable gluconic acid is obtained. This is achieved by that one d-glucose and alkali in the mentioned known method in equimolecular Applies quantities. The treatment is to be terminated as soon as the alkali hydroxy'd for the Formation of the alkali gluconate is consumed. The end of the implementation is external to recognize that the lively oxygen uptake only to a small extent he follows.

Beispiel Ansatz: 18 g Traubenzucker (1/1o Mol.), ioo ccm n/i Kalilauge, io g Palladium auf CaC03 (1/2%i9).Example approach: 18 g grape sugar (1/10 mol.), 100 ccm n / i potassium hydroxide solution, 10 g palladium on CaCO 3 (1/2% 19).

Die Umsetzung wird in einem Schüttelapparat vorgenommen; das Gefäß ist mit Zuleitungsrohr für Sauerstoff, Thermometer und Kühlschlange versehen. Die zu Beginn des Verfahrens ansteigende Temperatur wird bei etwa 35° gehalten, wobei die Umsetzung in etwa i Stunde beendet ist. Nachdem vom Beschleuniger abgenutscht worden ist, wird die Flüssigkeit mit der Lösung der auf Calciumglukonat berechneten Menge Calcitunchlorid (6 g) versetzt und auf etwa 6o ccm eingeengt, worauf das Calciumglukonat in' kristalliner Form gewonnen wird.The reaction is carried out in a shaker; the container is provided with a supply pipe for oxygen, thermometer and cooling coil. the The temperature rising at the beginning of the process is kept at about 35 °, whereby the reaction is completed in about one hour. After being sucked off by the accelerator has been, the liquid will be with the solution of the on Calcium gluconate calculated amount of calcitol chloride (6 g) and concentrated to about 6o ccm, whereupon the calcium gluconate is obtained in 'crystalline form.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Calcium glukonat, dadurch gekennzeichnet, daß man auf wässerige Lösungen, die Traubenzucker und Alkalihydroxyd in äquimolekularer Menge enthalten, Sauerstoff in Gegenwart von Palladium, welches auf "einen Träger, wie Calciumcarbonat, niedergeschlagen ist, so lange einwirken läßt, -bis kein Alkalihydrozyd mehr vorhanden ist, und das entstandene Alkaliglukonat durch Einwirkung von Calciumverbindungen in Calcittmglukonat umwandelt.PATENT CLAIM: Process for the production of calcium gluconate, thereby characterized in that one on aqueous solutions, the grape sugar and alkali hydroxide contained in equimolecular amount, oxygen in the presence of palladium, which act on "a carrier such as calcium carbonate for so long leaves, -until no more alkali metal hydroxide is present, and the resulting alkali metal gluconate converted into calcite gluconate by the action of calcium compounds.
DE1939B0186266 1939-02-09 1939-02-09 Process for the production of calcium gluconate Expired DE702729C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1939B0186266 DE702729C (en) 1939-02-09 1939-02-09 Process for the production of calcium gluconate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1939B0186266 DE702729C (en) 1939-02-09 1939-02-09 Process for the production of calcium gluconate

Publications (1)

Publication Number Publication Date
DE702729C true DE702729C (en) 1941-02-14

Family

ID=7010208

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1939B0186266 Expired DE702729C (en) 1939-02-09 1939-02-09 Process for the production of calcium gluconate

Country Status (1)

Country Link
DE (1) DE702729C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1037441B (en) * 1955-04-25 1958-08-28 Pfizer & Co C Process for the production of alkali or alkaline earth gluconates
DE974148C (en) * 1945-06-08 1960-09-29 Vapor Heating Corp Steam heating system with adjustable steam pressure

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE974148C (en) * 1945-06-08 1960-09-29 Vapor Heating Corp Steam heating system with adjustable steam pressure
DE1037441B (en) * 1955-04-25 1958-08-28 Pfizer & Co C Process for the production of alkali or alkaline earth gluconates

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