DE69930145T2 - Verfahren und Vorrichtung zum Bestimmen des Vorhandenseins von Lecks in einem System mit strömendem Fluid - Google Patents
Verfahren und Vorrichtung zum Bestimmen des Vorhandenseins von Lecks in einem System mit strömendem Fluid Download PDFInfo
- Publication number
- DE69930145T2 DE69930145T2 DE69930145T DE69930145T DE69930145T2 DE 69930145 T2 DE69930145 T2 DE 69930145T2 DE 69930145 T DE69930145 T DE 69930145T DE 69930145 T DE69930145 T DE 69930145T DE 69930145 T2 DE69930145 T2 DE 69930145T2
- Authority
- DE
- Germany
- Prior art keywords
- fluid
- pressure
- difference
- phase
- detection means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 115
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000000502 dialysis Methods 0.000 claims abstract description 24
- 238000001514 detection method Methods 0.000 claims description 75
- 239000000385 dialysis solution Substances 0.000 claims description 17
- 238000005086 pumping Methods 0.000 claims description 10
- 238000007639 printing Methods 0.000 claims description 3
- 238000012806 monitoring device Methods 0.000 claims 2
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 9
- 238000000108 ultra-filtration Methods 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 208000004434 Calcinosis Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
- G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
- G01M3/28—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds
- G01M3/2807—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds for pipes
- G01M3/2815—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds for pipes using pressure measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1647—Constructional aspects thereof with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/165—Constructional aspects thereof with a dialyser bypass on the dialysis fluid line
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/705—Testing of filters for leaks
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- External Artificial Organs (AREA)
- Examining Or Testing Airtightness (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802259A SE513838C2 (sv) | 1998-06-25 | 1998-06-25 | Metod jämte anordning för kalibrering av avkännande medel i ett system med ett strömmande fluidum |
| SE9802259 | 1998-06-25 | ||
| PCT/SE1999/000730 WO1999067615A1 (en) | 1998-06-25 | 1999-05-03 | Method and device for determining the existence of leaks in a system with flowing fluid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69930145D1 DE69930145D1 (de) | 2006-04-27 |
| DE69930145T2 true DE69930145T2 (de) | 2006-08-17 |
Family
ID=20411835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69930145T Expired - Lifetime DE69930145T2 (de) | 1998-06-25 | 1999-05-03 | Verfahren und Vorrichtung zum Bestimmen des Vorhandenseins von Lecks in einem System mit strömendem Fluid |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6530262B1 (enExample) |
| EP (1) | EP1088210B1 (enExample) |
| JP (1) | JP4221156B2 (enExample) |
| AT (1) | ATE319074T1 (enExample) |
| DE (1) | DE69930145T2 (enExample) |
| ES (1) | ES2258344T3 (enExample) |
| SE (1) | SE513838C2 (enExample) |
| WO (1) | WO1999067615A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572576B2 (en) * | 2001-07-07 | 2003-06-03 | Nxstage Medical, Inc. | Method and apparatus for leak detection in a fluid line |
| US20030128125A1 (en) | 2002-01-04 | 2003-07-10 | Burbank Jeffrey H. | Method and apparatus for machine error detection by combining multiple sensor inputs |
| US7040142B2 (en) * | 2002-01-04 | 2006-05-09 | Nxstage Medical, Inc. | Method and apparatus for leak detection in blood circuits combining external fluid detection and air infiltration detection |
| US9717840B2 (en) | 2002-01-04 | 2017-08-01 | Nxstage Medical, Inc. | Method and apparatus for machine error detection by combining multiple sensor inputs |
| DE10201109C1 (de) * | 2002-01-15 | 2003-01-23 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zur Detektion einer Leckage in einem Flüssigkeitssystem einer Blutbehandlungsvorrichtung |
| US20070004996A1 (en) * | 2005-06-20 | 2007-01-04 | Lovejoy David A | Needle disengagement sensing mechanism |
| US20090211341A1 (en) * | 2005-06-29 | 2009-08-27 | Klaus Witt | Leakage Detection Based on Fluid Property Changes |
| JP4795775B2 (ja) * | 2005-10-31 | 2011-10-19 | トキコテクノ株式会社 | 地下タンクの漏洩検査方法 |
| US8715235B2 (en) * | 2007-07-05 | 2014-05-06 | Baxter International Inc. | Dialysis system having disposable cassette and heated cassette interface |
| US7909795B2 (en) * | 2007-07-05 | 2011-03-22 | Baxter International Inc. | Dialysis system having disposable cassette and interface therefore |
| CN101614575B (zh) * | 2008-06-26 | 2012-05-23 | 北京谊安医疗系统股份有限公司 | 校正质量流量传感器的电压与气流速度关系的方法 |
| US8685251B2 (en) * | 2009-12-05 | 2014-04-01 | Home Dialysis Plus, Ltd. | Ultra-pasteurization for dialysis machines |
| WO2011069110A1 (en) * | 2009-12-05 | 2011-06-09 | Home Dialysis Plus, Ltd. | Modular dialysis system |
| US8753515B2 (en) * | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
| ES2403598T5 (es) † | 2009-12-22 | 2016-12-13 | Gambro Lundia Ab | Método y aparato para controlar una velocidad de flujo de fluido en un conducto de transporte de fluido de un dispositivo médico |
| DE102009060668A1 (de) * | 2009-12-28 | 2011-06-30 | Fresenius Medical Care Deutschland GmbH, 61352 | Vorrichtung und Verfahren zur Überwachung einer extrakorporalen Blutbehandlung |
| US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
| CN103037916A (zh) * | 2010-08-05 | 2013-04-10 | 日机装株式会社 | 血液净化装置及其漏液检查方法 |
| DE102010035498B4 (de) * | 2010-08-25 | 2012-08-02 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum Detektieren von Leckagen, System und medizintechnische Behandlungsvorrichtung |
| US9328969B2 (en) | 2011-10-07 | 2016-05-03 | Outset Medical, Inc. | Heat exchange fluid purification for dialysis system |
| GB2500998B (en) * | 2012-03-19 | 2019-01-16 | Ulc Robotics Inc | System and Method for Automated Integrity Testing |
| DE102013001587A1 (de) | 2013-01-30 | 2014-07-31 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung und Verfahren zur Regelung einer Behandlungsvorrichtung |
| US9506785B2 (en) | 2013-03-15 | 2016-11-29 | Rain Bird Corporation | Remote flow rate measuring |
| US20150314055A1 (en) | 2014-04-29 | 2015-11-05 | Michael Edward HOGARD | Dialysis system and methods |
| US10634538B2 (en) | 2016-07-13 | 2020-04-28 | Rain Bird Corporation | Flow sensor |
| JP7025408B2 (ja) | 2016-08-19 | 2022-02-24 | アウトセット・メディカル・インコーポレイテッド | 腹膜透析システム及び方法 |
| US10473494B2 (en) | 2017-10-24 | 2019-11-12 | Rain Bird Corporation | Flow sensor |
| CA3109237A1 (en) | 2018-08-23 | 2020-02-27 | Outset Medical, Inc. | Systems and methods for priming dialysis tubing sets |
| US11662242B2 (en) | 2018-12-31 | 2023-05-30 | Rain Bird Corporation | Flow sensor gauge |
| AU2020266584B2 (en) | 2019-04-30 | 2025-10-23 | Outset Medical, Inc. | Dialysis system and methods |
| US12443208B2 (en) | 2023-02-08 | 2025-10-14 | Rain Bird Corporation | Control zone devices, systems and methods |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3695094A (en) * | 1970-07-16 | 1972-10-03 | Halliburton Co | Leak detection method and system |
| JPS516083A (en) * | 1974-07-03 | 1976-01-19 | Nippon Kokan Kk | Ryutaino morekenchisochi |
| JPS6027372B2 (ja) * | 1979-06-11 | 1985-06-28 | 工業技術院長 | パイプラインの漏洩個所推定装置 |
| EP0094533B1 (de) * | 1982-05-15 | 1986-03-12 | Fried. Krupp Gesellschaft mit beschränkter Haftung | Verfahren zur Leckprüfung von Rohren oder Rohrnetzen |
| EP0188911A3 (en) * | 1984-12-25 | 1987-09-16 | Nippon Kokan Kabushiki Kaisha | Method and apparatus for detecting leaks in a gas pipe line |
| US4827430A (en) | 1987-05-11 | 1989-05-02 | Baxter International Inc. | Flow measurement system |
| US5375455A (en) * | 1990-08-30 | 1994-12-27 | Vista Research, Inc. | Methods for measuring flow rates to detect leaks |
| US5350357A (en) | 1993-03-03 | 1994-09-27 | Deka Products Limited Partnership | Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow |
| SE513524C2 (sv) | 1994-02-18 | 2000-09-25 | Gambro Med Tech Ab | System jämte förfarande för beräkning och/eller övervakning av ett vätskeflöde i en dialysapparat |
| DE59610774D1 (de) | 1995-09-27 | 2003-11-20 | Fresenius Medical Care De Gmbh | Vorrichtung zur Überwachung der Funktionssicherheit der Membran eines Dialysators |
| SE512266C2 (sv) * | 1997-07-09 | 2000-02-21 | Gambro Med Tech Ab | Förfarande och anordning för integritetstest av ett slangset avsett för användning i en cykler för peritonealdialys |
| US6082182A (en) * | 1997-10-20 | 2000-07-04 | Vista Research, Inc. | Apparatus for measuring the flow rate due to a leak in a pressurized pipe system |
| US5948969A (en) * | 1997-10-20 | 1999-09-07 | Vista Research, Inc. | Methods for measuring the flow rate due to a leak in a pressurized pipe system |
-
1998
- 1998-06-25 SE SE9802259A patent/SE513838C2/sv not_active IP Right Cessation
-
1999
- 1999-05-03 JP JP2000556223A patent/JP4221156B2/ja not_active Expired - Fee Related
- 1999-05-03 US US09/720,050 patent/US6530262B1/en not_active Expired - Fee Related
- 1999-05-03 EP EP99957197A patent/EP1088210B1/en not_active Expired - Lifetime
- 1999-05-03 ES ES99957197T patent/ES2258344T3/es not_active Expired - Lifetime
- 1999-05-03 WO PCT/SE1999/000730 patent/WO1999067615A1/en not_active Ceased
- 1999-05-03 DE DE69930145T patent/DE69930145T2/de not_active Expired - Lifetime
- 1999-05-03 AT AT99957197T patent/ATE319074T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1088210A1 (en) | 2001-04-04 |
| EP1088210B1 (en) | 2006-03-01 |
| JP4221156B2 (ja) | 2009-02-12 |
| SE9802259L (sv) | 2000-02-09 |
| ATE319074T1 (de) | 2006-03-15 |
| DE69930145D1 (de) | 2006-04-27 |
| JP2002519630A (ja) | 2002-07-02 |
| ES2258344T3 (es) | 2006-08-16 |
| WO1999067615A1 (en) | 1999-12-29 |
| US6530262B1 (en) | 2003-03-11 |
| SE513838C2 (sv) | 2000-11-13 |
| SE9802259D0 (sv) | 1998-06-25 |
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