DE69925362D1 - Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten - Google Patents
Screeningverfahren für die aktivität von agenzien unter verwendung von teleostenInfo
- Publication number
- DE69925362D1 DE69925362D1 DE69925362T DE69925362T DE69925362D1 DE 69925362 D1 DE69925362 D1 DE 69925362D1 DE 69925362 T DE69925362 T DE 69925362T DE 69925362 T DE69925362 T DE 69925362T DE 69925362 D1 DE69925362 D1 DE 69925362D1
- Authority
- DE
- Germany
- Prior art keywords
- activity
- telesis
- agents
- screening method
- screening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000694 effects Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 3
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4603—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from fish
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7578398P | 1998-02-23 | 1998-02-23 | |
US75783P | 1998-02-23 | ||
US10095098P | 1998-09-18 | 1998-09-18 | |
US100950P | 1998-09-18 | ||
PCT/US1999/003852 WO1999042606A1 (en) | 1998-02-23 | 1999-02-22 | Methods of screening agents for activity using teleosts |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925362D1 true DE69925362D1 (de) | 2005-06-23 |
DE69925362T2 DE69925362T2 (de) | 2006-01-19 |
Family
ID=26757274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925362T Expired - Lifetime DE69925362T2 (de) | 1998-02-23 | 1999-02-22 | Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten |
Country Status (8)
Country | Link |
---|---|
US (3) | US6299858B1 (de) |
EP (3) | EP1548123A1 (de) |
JP (2) | JP4383533B2 (de) |
AT (2) | ATE512233T1 (de) |
AU (1) | AU749688B2 (de) |
CA (1) | CA2320406C (de) |
DE (1) | DE69925362T2 (de) |
WO (1) | WO1999042606A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6881571B1 (en) | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
US6656449B1 (en) * | 1998-02-23 | 2003-12-02 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
ATE512233T1 (de) | 1998-02-23 | 2011-06-15 | Phylonix Pharmaceuticals Inc | Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten |
US7951989B2 (en) | 1998-02-23 | 2011-05-31 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
EP1137809A1 (de) * | 1998-12-09 | 2001-10-04 | Vistagen, Inc. | Typisierung der toxizität mittels embryoider körper |
FR2798392B1 (fr) * | 1999-09-13 | 2005-07-15 | Exonhit Therapeutics Sa | Marqueurs genetiques de la toxicite, preparation et utilisations |
GR1004180B (el) * | 2000-03-28 | 2003-03-11 | ����������� ����� ��������� (����) | Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων |
US7250304B2 (en) * | 2000-03-31 | 2007-07-31 | The Regents Of The University Of California | Functional assay of high-density lipoprotein |
US20030040505A1 (en) * | 2000-03-31 | 2003-02-27 | The Regents Of The University Of California | Synthetic phospholipids to ameliorate atherosclerosis and other inflammatory conditions |
EP1160570A1 (de) * | 2000-05-27 | 2001-12-05 | ARTEMIS Pharmaceuticals GmbH | Verfahren zur identifizierung von agenzien und genen, die die kardiovaskuläre Funktion beeinflussen |
AU2001265996A1 (en) * | 2000-05-27 | 2001-12-11 | Exelixis Deutschland Gmbh | Method for the identification of agents and genes influencing cardiovascular function |
ES2334639T3 (es) | 2000-06-14 | 2010-03-15 | Vistagen, Inc. | Tipificacion de toxicidad empleando celulas madre hepaticas. |
WO2002031202A2 (en) * | 2000-10-10 | 2002-04-18 | Thomas Jefferson University | High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds |
US6943025B2 (en) | 2001-01-10 | 2005-09-13 | Children's Medical Center Corporation | Method for identifying genes involved in cell proliferation |
JP2003052354A (ja) * | 2001-07-18 | 2003-02-25 | Nagoya Industrial Science Research Inst | 魚類胚を用いるスクリーニング方法 |
GB2382579B (en) * | 2001-11-30 | 2003-11-12 | Daniolabs Ltd | Disease models, assays, methods and means |
AU2002357867A1 (en) * | 2001-12-17 | 2003-06-30 | Children's Medical Center Corporation | Method of screening compounds |
DE50211123D1 (de) * | 2002-09-16 | 2007-12-06 | Pan Biotech Gmbh | Verfahren zur kultivierung von zellen, insbesondere menschlicher oder tierischer zellen |
US20060019375A1 (en) * | 2002-09-16 | 2006-01-26 | Josef Seidl | Device for culturing cells, particularly human or animal cells |
US7192770B2 (en) * | 2002-09-20 | 2007-03-20 | The General Hospiatal Corporation | Screening for skin wrinkling modulators |
WO2004027378A2 (en) * | 2002-09-20 | 2004-04-01 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
DE10252806A1 (de) * | 2002-11-13 | 2004-06-03 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | Verwendung von Fischlarven als Screening-Modell |
US7465848B2 (en) * | 2002-11-20 | 2008-12-16 | The General Hospital Corporation | Zebrafish assay |
US20040133114A1 (en) * | 2002-11-20 | 2004-07-08 | Macrae Calum A. | Zebrafish Assay |
AU2003303742A1 (en) * | 2002-12-24 | 2004-11-04 | Board Of Regents, The University Of Texas System | Screening methods using zebrafish to identify thrombotic and anti-thrombotic compounds and genes |
GB0301977D0 (en) * | 2003-01-28 | 2003-02-26 | Daniolabs Ltd | Method for creating a model amenable to high-throughput screening |
EP1667733A1 (de) * | 2003-09-29 | 2006-06-14 | Oxygenix Co., Ltd. | Vefahren zur beurteilung der organfunktion |
GB0403490D0 (en) * | 2004-02-17 | 2004-03-24 | Daniolabs Ltd | Screening methods |
GB2413847A (en) * | 2004-04-26 | 2005-11-09 | Daniolabs Ltd | Bone disease models |
US20080276327A1 (en) * | 2004-05-21 | 2008-11-06 | University Of Utah Research Foundation | Methods and Compositions Related to Delivery of Chemical Compounds to Invertebrate Embryos |
US20060063202A1 (en) * | 2004-08-11 | 2006-03-23 | John B. Pierce Laboratory | High throughput method and system for screening candidate compounds for activity against epilepsy and other neurological diseases |
ITRM20050169A1 (it) * | 2005-04-07 | 2006-10-08 | Lay Line Genomics Spa | Uso di nothobranchius furzeri come sistema modello per la caratterizzazione di geni e farmaci che controllano l'invecchiamento. |
EP2272972A1 (de) | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogene und fluorogene Verbindungen und Verfahren für den Nachweis von Molekülen oder Leiden |
US7700347B2 (en) * | 2005-06-30 | 2010-04-20 | The Forsyth Institute | Methods and apparatuses for conducting assays in animals |
EP1915607A1 (de) * | 2005-07-19 | 2008-04-30 | Physical Sciences, Inc. | Microwell-array mit bilderstellung in seitenansicht |
FR2889936B1 (fr) * | 2005-09-01 | 2007-12-21 | Sod Conseils Rech Applic | Methode pour quantifier une neurotoxine cholinergique dans un echantillon |
GB0523239D0 (en) * | 2005-11-14 | 2005-12-21 | Vastox Plc | Quantification method |
US20110126300A1 (en) * | 2005-12-20 | 2011-05-26 | The Trustees Of The University Of Pennsylvania | High Through-Put Method of Screening Compounds for Pharmacological Activity |
NZ572178A (en) * | 2006-05-04 | 2012-01-12 | Genentech Inc | Model systems and methods relating to zebrafish pro-apoptotic (zpa) polypeptides |
WO2008011017A2 (en) * | 2006-07-18 | 2008-01-24 | The General Hospital Corporation | Methods and compositions for treating vascular disease |
US7655832B2 (en) * | 2006-08-07 | 2010-02-02 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Rapid-throughput teleost regeneration assay |
EP2027283B1 (de) * | 2007-01-08 | 2011-09-28 | City University of Hong Kong | Verfahren zum screening eines agens mit angiogen-modulierenden aktivitäten unter verwendung eines teleost-embryos |
US7897363B2 (en) | 2007-06-12 | 2011-03-01 | Phylonix Pharmaceuticals, Inc. | Methods of screening an agent for an activity in an isolated eye of a teleost |
CA2713423A1 (en) | 2008-01-18 | 2009-07-23 | North Carolina State University | Peptides and methods of use as therapeutics and screening agents |
US8288559B2 (en) * | 2008-08-18 | 2012-10-16 | Promega Corporation | Luminogenic compounds and methods to detect cytochrome P450 3A enzymes |
US8687857B2 (en) * | 2008-11-07 | 2014-04-01 | General Electric Company | Systems and methods for automated extraction of high-content information from whole organisms |
US20100119119A1 (en) * | 2008-11-07 | 2010-05-13 | General Electric Company | Automated systems and methods for screening zebrafish |
EP2452192A1 (de) * | 2009-07-08 | 2012-05-16 | Zf Screens B.V. | Hochdurchsatzverfahren und system für in-vivo-screening |
US8865630B2 (en) * | 2010-02-26 | 2014-10-21 | Massachusetts Institute Of Technology | High-throughput platform for in-vivo sub-cellular screens on vertebrate larvae |
KR101800878B1 (ko) * | 2010-03-31 | 2017-11-27 | 전남대학교 산학협력단 | 비-형광성 형광 단백질을 이용한 유전독성 분석방법 |
WO2012154552A1 (en) | 2011-05-06 | 2012-11-15 | Phylonix Pharmaceuticals, Inc. | Method and device for removing particles from liquid and placing them into a holding device |
EP3099683B1 (de) | 2014-01-29 | 2020-08-05 | Promega Corporation | Chinonmaskierte sonden als markierungsreagenzien für zellaufnahmemessungen |
WO2019070546A1 (en) * | 2017-10-03 | 2019-04-11 | The Johns Hopkins University | PULMONARY CELL TREATMENTS FOR PREVENTING OR TREATING DISEASE |
CN110865056A (zh) * | 2019-11-06 | 2020-03-06 | 南通大学 | 一种转基因斑马鱼蛋白荧光的保存方法 |
US20230134859A1 (en) | 2020-03-31 | 2023-05-04 | Sky Pharma Co., Ltd. | Method for screening for, method for producing, and method for designing drug active ingredients |
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WO1995011989A1 (en) * | 1993-10-29 | 1995-05-04 | Invitro International | In vitro fluid toxicity bioassay |
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ATE512233T1 (de) | 1998-02-23 | 2011-06-15 | Phylonix Pharmaceuticals Inc | Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten |
US7951989B2 (en) | 1998-02-23 | 2011-05-31 | Phylonix Pharmaceuticals, Inc. | Methods of screening agents for activity using teleosts |
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-
1999
- 1999-02-22 AT AT07018743T patent/ATE512233T1/de not_active IP Right Cessation
- 1999-02-22 EP EP05001508A patent/EP1548123A1/de not_active Withdrawn
- 1999-02-22 CA CA2320406A patent/CA2320406C/en not_active Expired - Fee Related
- 1999-02-22 EP EP07018743A patent/EP1878799B1/de not_active Expired - Lifetime
- 1999-02-22 DE DE69925362T patent/DE69925362T2/de not_active Expired - Lifetime
- 1999-02-22 AT AT99934309T patent/ATE295899T1/de not_active IP Right Cessation
- 1999-02-22 JP JP2000532546A patent/JP4383533B2/ja not_active Expired - Fee Related
- 1999-02-22 WO PCT/US1999/003852 patent/WO1999042606A1/en active IP Right Grant
- 1999-02-22 US US09/255,397 patent/US6299858B1/en not_active Expired - Lifetime
- 1999-02-22 AU AU33074/99A patent/AU749688B2/en not_active Ceased
- 1999-02-22 EP EP99934309A patent/EP1066402B1/de not_active Expired - Lifetime
-
2001
- 2001-09-05 US US09/947,635 patent/US7041276B2/en not_active Expired - Fee Related
-
2005
- 2005-11-15 US US11/280,849 patent/US7435870B2/en not_active Expired - Fee Related
-
2009
- 2009-05-18 JP JP2009120423A patent/JP2009186490A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2320406A1 (en) | 1999-08-26 |
JP2009186490A (ja) | 2009-08-20 |
US20020025297A1 (en) | 2002-02-28 |
DE69925362T2 (de) | 2006-01-19 |
US7435870B2 (en) | 2008-10-14 |
EP1878799A2 (de) | 2008-01-16 |
US20060104905A1 (en) | 2006-05-18 |
ATE512233T1 (de) | 2011-06-15 |
EP1066402A4 (de) | 2001-06-13 |
JP4383533B2 (ja) | 2009-12-16 |
US7041276B2 (en) | 2006-05-09 |
EP1066402B1 (de) | 2005-05-18 |
WO1999042606A1 (en) | 1999-08-26 |
CA2320406C (en) | 2011-06-21 |
EP1066402A1 (de) | 2001-01-10 |
JP2002504667A (ja) | 2002-02-12 |
AU749688B2 (en) | 2002-07-04 |
EP1878799A3 (de) | 2008-01-23 |
EP1878799B1 (de) | 2011-06-08 |
AU3307499A (en) | 1999-09-06 |
ATE295899T1 (de) | 2005-06-15 |
US6299858B1 (en) | 2001-10-09 |
EP1548123A1 (de) | 2005-06-29 |
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