DE69913497D1 - Diterpenderivate und entzündungshemmende schmerzmittel die diese enthalten - Google Patents
Diterpenderivate und entzündungshemmende schmerzmittel die diese enthaltenInfo
- Publication number
- DE69913497D1 DE69913497D1 DE69913497T DE69913497T DE69913497D1 DE 69913497 D1 DE69913497 D1 DE 69913497D1 DE 69913497 T DE69913497 T DE 69913497T DE 69913497 T DE69913497 T DE 69913497T DE 69913497 D1 DE69913497 D1 DE 69913497D1
- Authority
- DE
- Germany
- Prior art keywords
- diterpender
- paints
- inflammatory
- derivatives
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/36—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/02—Saturated compounds containing hydroxy or O-metal groups
- C07C62/06—Saturated compounds containing hydroxy or O-metal groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR9802441 | 1998-01-26 | ||
KR19980002441 | 1998-01-26 | ||
PCT/KR1999/000038 WO1999037600A1 (en) | 1998-01-26 | 1999-01-25 | Diterpene derivatives and anti-inflammatory analgesic agents comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69913497D1 true DE69913497D1 (de) | 2004-01-22 |
DE69913497T2 DE69913497T2 (de) | 2004-09-16 |
Family
ID=19532190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69913497T Expired - Lifetime DE69913497T2 (de) | 1998-01-26 | 1999-01-25 | Diterpenderivate und entzündungshemmende schmerzmittel die diese enthalten |
Country Status (9)
Country | Link |
---|---|
US (1) | US6593363B1 (de) |
EP (1) | EP1056710B1 (de) |
JP (1) | JP4615710B2 (de) |
KR (1) | KR100566422B1 (de) |
CN (1) | CN1171846C (de) |
AU (1) | AU2187699A (de) |
DE (1) | DE69913497T2 (de) |
ES (1) | ES2211030T3 (de) |
WO (1) | WO1999037600A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1361760A (zh) * | 1999-05-14 | 2002-07-31 | 尼瑞斯药品公司 | 新的白介素-1和肿瘤坏死因子-α调节剂、所述调节剂的合成以及使用所述调节剂的方法 |
US7119223B2 (en) | 1999-05-14 | 2006-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators |
KR20020019136A (ko) * | 2000-09-05 | 2002-03-12 | 서영거 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
KR100383149B1 (ko) * | 2000-12-12 | 2003-05-12 | 한국생명공학연구원 | 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도 |
WO2002079137A1 (en) * | 2001-03-28 | 2002-10-10 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use |
JP2005532992A (ja) * | 2002-01-25 | 2005-11-04 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 肝炎治療剤及び予防剤または肝臓保護剤として有用なソムオガルピ(AcanthopanaxKoreanum)抽出物 |
KR20030069232A (ko) * | 2002-02-04 | 2003-08-27 | 주식회사 팜트리 | 디테르펜 유도체 및 이를 포함하는 소염진통제 |
EP1912932B1 (de) * | 2005-07-21 | 2012-05-02 | Nereus Pharmaceuticals, Inc. | Interleukin-1- und tumornekrosefaktor-a-modulatoren, synthese solcher modulatoren und verfahren unter anwendung solcher modulatoren |
WO2011078652A1 (en) | 2009-12-21 | 2011-06-30 | Biotropics Malaysia Berhad | Orthosiphon stamineus extracts with beneficial use as cognition enhancer |
KR102339450B1 (ko) * | 2019-11-28 | 2021-12-15 | 대한민국 | 독활에서 유래한 신규 화합물 및 이를 포함한 항염증성 조성물 |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0145941B1 (ko) * | 1994-06-13 | 1998-08-17 | 김은영 | 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물 |
CN1361760A (zh) * | 1999-05-14 | 2002-07-31 | 尼瑞斯药品公司 | 新的白介素-1和肿瘤坏死因子-α调节剂、所述调节剂的合成以及使用所述调节剂的方法 |
-
1999
- 1999-01-25 ES ES99901968T patent/ES2211030T3/es not_active Expired - Lifetime
- 1999-01-25 KR KR1019990002206A patent/KR100566422B1/ko not_active IP Right Cessation
- 1999-01-25 AU AU21876/99A patent/AU2187699A/en not_active Abandoned
- 1999-01-25 US US09/600,774 patent/US6593363B1/en not_active Expired - Fee Related
- 1999-01-25 EP EP99901968A patent/EP1056710B1/de not_active Expired - Lifetime
- 1999-01-25 DE DE69913497T patent/DE69913497T2/de not_active Expired - Lifetime
- 1999-01-25 JP JP2000528526A patent/JP4615710B2/ja not_active Expired - Fee Related
- 1999-01-25 WO PCT/KR1999/000038 patent/WO1999037600A1/en active IP Right Grant
- 1999-01-25 CN CNB998024295A patent/CN1171846C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1289319A (zh) | 2001-03-28 |
EP1056710A1 (de) | 2000-12-06 |
WO1999037600A1 (en) | 1999-07-29 |
JP2003502271A (ja) | 2003-01-21 |
ES2211030T3 (es) | 2004-07-01 |
CN1171846C (zh) | 2004-10-20 |
US6593363B1 (en) | 2003-07-15 |
EP1056710B1 (de) | 2003-12-10 |
KR100566422B1 (ko) | 2006-04-07 |
AU2187699A (en) | 1999-08-09 |
DE69913497T2 (de) | 2004-09-16 |
JP4615710B2 (ja) | 2011-01-19 |
KR19990072290A (ko) | 1999-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |