DE69903716D1 - Kombination von einem inversen agonisten des gaba-a alpha-5 rezeptor subtyps und nicotinerge agonisten - Google Patents
Kombination von einem inversen agonisten des gaba-a alpha-5 rezeptor subtyps und nicotinerge agonistenInfo
- Publication number
- DE69903716D1 DE69903716D1 DE69903716T DE69903716T DE69903716D1 DE 69903716 D1 DE69903716 D1 DE 69903716D1 DE 69903716 T DE69903716 T DE 69903716T DE 69903716 T DE69903716 T DE 69903716T DE 69903716 D1 DE69903716 D1 DE 69903716D1
- Authority
- DE
- Germany
- Prior art keywords
- combination
- alpha
- nicotinerge
- gaba
- agonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940125425 inverse agonist Drugs 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 239000000181 nicotinic agonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9805559.3A GB9805559D0 (en) | 1998-03-16 | 1998-03-16 | A combination of therapeutic agents |
PCT/GB1999/000800 WO1999047142A1 (en) | 1998-03-16 | 1999-03-16 | Combination of a gaba-a alpha 5 inverse agonist and a nicotinic agonist |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69903716D1 true DE69903716D1 (de) | 2002-12-05 |
DE69903716T2 DE69903716T2 (de) | 2003-08-14 |
Family
ID=10828630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69903716T Expired - Fee Related DE69903716T2 (de) | 1998-03-16 | 1999-03-16 | Kombination von einem inversen agonisten des gaba-a alpha-5 rezeptor subtyps und nicotinerge agonisten |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1061925B1 (de) |
JP (1) | JP2002506822A (de) |
AT (1) | ATE226823T1 (de) |
AU (1) | AU752013B2 (de) |
CA (1) | CA2324237A1 (de) |
DE (1) | DE69903716T2 (de) |
ES (1) | ES2185321T3 (de) |
GB (1) | GB9805559D0 (de) |
WO (1) | WO1999047142A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9821179D0 (en) * | 1998-09-30 | 1998-11-25 | Merck Sharp & Dohme | Therapeutic use |
US6627624B1 (en) | 1999-04-02 | 2003-09-30 | Neurogen Corporation | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
US6281237B1 (en) | 1999-04-02 | 2001-08-28 | Neurogen Corporation | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives |
US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
US6723332B2 (en) | 2000-05-26 | 2004-04-20 | Neurogen Corporation | Oxomidazopyridine-carboxamides |
AU2001273639A1 (en) | 2000-06-26 | 2002-01-08 | Neurogen Corporation | Aryl fused substituted 4-oxy-pyridines |
IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE62662B1 (en) * | 1989-01-06 | 1995-02-22 | Elan Corp Plc | Use of nicotine in the treatment of conditions susceptible to said treatment |
GB9503601D0 (en) * | 1995-02-23 | 1995-04-12 | Merck Sharp & Dohme | Method of treatment and method of manufacture of medicament |
EP0915877A1 (de) * | 1996-07-25 | 1999-05-19 | MERCK SHARP & DOHME LTD. | Substituierte triazolo-pyridazinderivate als inverse agonisten des gaba-a alpha-5 rezeptor subtyps |
-
1998
- 1998-03-16 GB GBGB9805559.3A patent/GB9805559D0/en not_active Ceased
-
1999
- 1999-03-16 ES ES99909110T patent/ES2185321T3/es not_active Expired - Lifetime
- 1999-03-16 AT AT99909110T patent/ATE226823T1/de not_active IP Right Cessation
- 1999-03-16 CA CA002324237A patent/CA2324237A1/en not_active Abandoned
- 1999-03-16 JP JP2000536382A patent/JP2002506822A/ja not_active Withdrawn
- 1999-03-16 EP EP99909110A patent/EP1061925B1/de not_active Expired - Lifetime
- 1999-03-16 DE DE69903716T patent/DE69903716T2/de not_active Expired - Fee Related
- 1999-03-16 WO PCT/GB1999/000800 patent/WO1999047142A1/en active IP Right Grant
- 1999-03-16 AU AU28477/99A patent/AU752013B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2324237A1 (en) | 1999-09-23 |
EP1061925A1 (de) | 2000-12-27 |
ATE226823T1 (de) | 2002-11-15 |
JP2002506822A (ja) | 2002-03-05 |
DE69903716T2 (de) | 2003-08-14 |
WO1999047142A1 (en) | 1999-09-23 |
AU752013B2 (en) | 2002-09-05 |
EP1061925B1 (de) | 2002-10-30 |
GB9805559D0 (en) | 1998-05-13 |
AU2847799A (en) | 1999-10-11 |
ES2185321T3 (es) | 2003-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |