DE69901895T2 - Verbesserte kristallstrukturen - Google Patents

Verbesserte kristallstrukturen

Info

Publication number
DE69901895T2
DE69901895T2 DE69901895T DE69901895T DE69901895T2 DE 69901895 T2 DE69901895 T2 DE 69901895T2 DE 69901895 T DE69901895 T DE 69901895T DE 69901895 T DE69901895 T DE 69901895T DE 69901895 T2 DE69901895 T2 DE 69901895T2
Authority
DE
Germany
Prior art keywords
crystals
crystal structures
improved crystal
compositions
lactose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69901895T
Other languages
English (en)
Other versions
DE69901895D1 (de
Inventor
Christopher Marriott
Peter Martin
Ming Zeng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69901895D1 publication Critical patent/DE69901895D1/de
Application granted granted Critical
Publication of DE69901895T2 publication Critical patent/DE69901895T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69901895T 1998-03-26 1999-03-24 Verbesserte kristallstrukturen Expired - Lifetime DE69901895T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9806477.7A GB9806477D0 (en) 1998-03-26 1998-03-26 Improved crystals
PCT/EP1999/001966 WO1999048475A1 (en) 1998-03-26 1999-03-24 Improved crystal structure

Publications (2)

Publication Number Publication Date
DE69901895D1 DE69901895D1 (de) 2002-07-25
DE69901895T2 true DE69901895T2 (de) 2002-12-19

Family

ID=10829300

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901895T Expired - Lifetime DE69901895T2 (de) 1998-03-26 1999-03-24 Verbesserte kristallstrukturen

Country Status (11)

Country Link
US (1) US6875449B1 (de)
EP (1) EP1067903B1 (de)
JP (1) JP4312380B2 (de)
AT (1) ATE219354T1 (de)
AU (1) AU3598199A (de)
CA (1) CA2325551A1 (de)
DE (1) DE69901895T2 (de)
ES (1) ES2178422T3 (de)
GB (1) GB9806477D0 (de)
WO (1) WO1999048475A1 (de)
ZA (1) ZA200005032B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005009194A1 (de) * 2005-03-01 2006-09-14 Hpp-Hommel Pharmaceuticals Production Gmbh Verfahren zur Herstellung von polymorph stabilem Triamcinolonacetonid

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
JP2004537377A (ja) * 2001-08-09 2004-12-16 グラクソ　グループ　リミテッド 製薬組成物を有する吸入装置
MX2007009656A (es) 2005-02-10 2007-11-07 Glaxo Group Ltd Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma.
GB0617171D0 (en) * 2006-08-31 2006-10-11 Generics Uk Ltd Novel compositions and methods
IL186290A0 (en) * 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
CN101239996B (zh) * 2008-01-04 2010-10-27 华南理工大学 一种高剪切力微晶乳糖制备方法
WO2010002712A2 (en) * 2008-06-30 2010-01-07 3M Innovative Properties Company Method of crystallization
US9326538B2 (en) 2010-04-07 2016-05-03 Kraft Foods Group Brands Llc Intermediate moisture bar using a dairy-based binder
US9232807B2 (en) 2011-09-30 2016-01-12 Kraft Foods Group Brands Llc Dairy-based foods having high levels of lactose
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2847207B1 (de) 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Nanokristalle von Fluticasonpropionat
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
GB201711233D0 (en) 2017-07-12 2017-08-23 Aston Particle Tech Ltd Coating method
CN113476428B (zh) * 2021-01-28 2022-03-29 朗天药业(湖北)有限公司 一种吸入用硫酸沙丁胺醇溶液及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134498A (en) * 1981-02-12 1982-08-19 Hayashibara Biochem Lab Inc Anhydrous crystalline maltitol and its preparation and use
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
DE69313865T2 (de) * 1992-10-16 1998-02-12 Glaxo Group Ltd Geschmacksmaskierende zusammensetzungen von ranitidin
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
JPH11506100A (ja) 1995-06-01 1999-06-02 ジー．ディー．サール アンド カンパニー ミソプロストールの安定化された分散系
US6129905A (en) * 1997-04-21 2000-10-10 Aeropharm Technology, Inc. Aerosol formulations containing a sugar as a dispersant
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
WO2000022083A1 (en) * 1998-10-15 2000-04-20 The Procter & Gamble Company Method for making a nanoporous granular material and a detergent composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005009194A1 (de) * 2005-03-01 2006-09-14 Hpp-Hommel Pharmaceuticals Production Gmbh Verfahren zur Herstellung von polymorph stabilem Triamcinolonacetonid
DE102005009194B4 (de) * 2005-03-01 2006-12-14 Hpp-Hommel Pharmaceuticals Production Gmbh Verfahren zur Herstellung von polymorph stabilem Triamcinolonacetonid

Also Published As

Publication number Publication date
EP1067903A1 (de) 2001-01-17
JP4312380B2 (ja) 2009-08-12
US6875449B1 (en) 2005-04-05
CA2325551A1 (en) 1999-09-30
ATE219354T1 (de) 2002-07-15
AU3598199A (en) 1999-10-18
JP2002507471A (ja) 2002-03-12
ES2178422T3 (es) 2002-12-16
DE69901895D1 (de) 2002-07-25
EP1067903B1 (de) 2002-06-19
GB9806477D0 (en) 1998-05-27
WO1999048475A1 (en) 1999-09-30
ZA200005032B (en) 2001-09-20

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