DE69834133D1 - Polyamid-oligomere - Google Patents
Polyamid-oligomereInfo
- Publication number
- DE69834133D1 DE69834133D1 DE69834133T DE69834133T DE69834133D1 DE 69834133 D1 DE69834133 D1 DE 69834133D1 DE 69834133 T DE69834133 T DE 69834133T DE 69834133 T DE69834133 T DE 69834133T DE 69834133 D1 DE69834133 D1 DE 69834133D1
- Authority
- DE
- Germany
- Prior art keywords
- oligomers
- virusomes
- micelles
- liposomes
- polyamide oligomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11365897P | 1997-12-23 | 1997-12-23 | |
US7385298P | 1998-02-02 | 1998-02-02 | |
PCT/CA1998/001185 WO1999033493A1 (en) | 1997-12-23 | 1998-12-22 | Polyamide oligomers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69834133D1 true DE69834133D1 (de) | 2006-05-18 |
Family
ID=26754961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69834133T Expired - Lifetime DE69834133D1 (de) | 1997-12-23 | 1998-12-22 | Polyamid-oligomere |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1041976B1 (de) |
JP (1) | JP2001527052A (de) |
AT (1) | ATE322255T1 (de) |
AU (1) | AU751434B2 (de) |
CA (1) | CA2315695A1 (de) |
DE (1) | DE69834133D1 (de) |
WO (1) | WO1999033493A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
EP2138191A1 (de) | 1998-01-05 | 2009-12-30 | University Of Washington | Erhöhter Transport unter Benutzung membranzerstörender Stoffe |
WO2003000291A1 (en) * | 2001-06-22 | 2003-01-03 | Techno Network Shikoku Co., Ltd. | Lipid vesicles, process for producing lipid vesicles and method of immobilizing gene on lipid vesicles |
AU2003217204A1 (en) * | 2002-01-15 | 2003-07-30 | Vanderbilt University | Composition and imaging methods for pharmacokinetic and pharmacodynamic evaluation of therapeutic delivery system |
DE50312971D1 (de) * | 2002-04-29 | 2010-09-23 | Biotesys Gmbh | Polymerisierte peptid-modifizierte lipide als biologische transportsysteme für mikronutrients |
EP3100719A3 (de) | 2002-05-15 | 2017-02-22 | California Pacific Medical Center | Zuführung von nukleinsäureähnlichen verbindungen |
US7956043B2 (en) | 2002-12-11 | 2011-06-07 | Coley Pharmaceutical Group, Inc. | 5′ CpG nucleic acids and methods of use |
US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
DE602007007618D1 (de) * | 2006-05-18 | 2010-08-19 | Univ Muenchen L Maximilians | Kationische liposomale zubereitungen zur behandlung von rheumatoider arthritis |
ES2921724T1 (es) | 2011-12-07 | 2022-08-31 | Alnylam Pharmaceuticals Inc | Lípidos biodegradables para la administración de agentes activos |
SI3766916T1 (sl) | 2014-06-25 | 2023-01-31 | Acuitas Therapeutics Inc. | Formulacije novih lipidov in lipidnih nanodelcev za dostavo nukleinskih kislin |
WO2017004143A1 (en) | 2015-06-29 | 2017-01-05 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
CN113636947A (zh) | 2015-10-28 | 2021-11-12 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
CN110799492B (zh) | 2017-04-28 | 2023-06-27 | 爱康泰生治疗公司 | 用于递送核酸的新型羰基脂质和脂质纳米颗粒制剂 |
EP3668833A1 (de) | 2017-08-16 | 2020-06-24 | Acuitas Therapeutics, Inc. | Lipide zur verwendung in lipidnanopartikelformulierungen |
WO2019036028A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
WO2019036030A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS |
EP3908568A1 (de) | 2019-01-11 | 2021-11-17 | Acuitas Therapeutics, Inc. | Lipide zur lipidnanopartikelfreisetzung von wirkstoffen |
CN113636931B (zh) * | 2021-08-05 | 2024-02-13 | 康龙化成(宁波)科技发展有限公司 | 基因编码化合物库起始头片段化合物及其在基因编码化合物库合成上的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4426330A (en) * | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US5135737A (en) * | 1986-11-10 | 1992-08-04 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Amplifier molecules for enhancement of diagnosis and therapy |
JPH0720857B2 (ja) * | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
US5324844A (en) * | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5527528A (en) * | 1989-10-20 | 1996-06-18 | Sequus Pharmaceuticals, Inc. | Solid-tumor treatment method |
US5356633A (en) * | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
DE4004296A1 (de) * | 1990-02-13 | 1991-08-14 | Hoechst Ag | Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays |
JP3351476B2 (ja) * | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
-
1998
- 1998-12-22 EP EP98962158A patent/EP1041976B1/de not_active Expired - Lifetime
- 1998-12-22 DE DE69834133T patent/DE69834133D1/de not_active Expired - Lifetime
- 1998-12-22 AU AU17460/99A patent/AU751434B2/en not_active Ceased
- 1998-12-22 AT AT98962158T patent/ATE322255T1/de not_active IP Right Cessation
- 1998-12-22 JP JP2000526243A patent/JP2001527052A/ja active Pending
- 1998-12-22 CA CA002315695A patent/CA2315695A1/en not_active Abandoned
- 1998-12-22 WO PCT/CA1998/001185 patent/WO1999033493A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2001527052A (ja) | 2001-12-25 |
WO1999033493A1 (en) | 1999-07-08 |
AU1746099A (en) | 1999-07-19 |
AU751434B2 (en) | 2002-08-15 |
CA2315695A1 (en) | 1999-07-08 |
EP1041976A1 (de) | 2000-10-11 |
ATE322255T1 (de) | 2006-04-15 |
EP1041976B1 (de) | 2006-04-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69834133D1 (de) | Polyamid-oligomere | |
DE69527857T2 (de) | Peptid-nukleinsäure-konjugate | |
CA2196780A1 (en) | A liposomal delivery system comprising cationic lipopolyamines and neutral lipids for delivery of biologically active agents | |
NO20001683L (no) | Peptid/lipid-kompleksdannelse ved samlyofilisering | |
ATE273320T1 (de) | Fusogene liposomen | |
EP2206787A3 (de) | Peptidverstärkte Transfektionen | |
DE69708919T2 (de) | Neue liposomkomplexe mit erhöhter systemischer verabreichung | |
CA2201120A1 (en) | Polyethylene glycol modified ceramide lipids and liposome uses thereof | |
HK1030768A1 (en) | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents. | |
ATE362991T1 (de) | Kondensierte plasmid-liposome komplex zur transfektion | |
ATE453380T1 (de) | Verabreichung von in lipidvesikeln verpackten kleinen hydrophilen molekülen | |
NO993866L (no) | Legemiddel mot lymfatiske tumorer | |
DE69830249D1 (de) | Zielgerichtete liposomen zur verabreichung von genen | |
DE60117247D1 (de) | Phosphoramidat-prodrugs | |
IT1270618B (it) | Proteine ad attivita' antitumorale | |
WO1996040627A3 (en) | Thiocationic lipids, pharmaceutical compositions and methods of use thereof | |
ATE214708T1 (de) | Kationische mittel zur transfektion von nukleinsäuren | |
AU2003222944A1 (en) | Novel coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods | |
ATE359764T1 (de) | Durch liposome vermittelte dna verabreichung | |
ITRM970113A0 (it) | Kit per la somministrazione di quantita' predosate di farmaci per via ionoforetica. | |
IT236018Y1 (it) | Macchina motrice semovente agevolatrice di raccolta per l'orticoltura. | |
CA2051439A1 (en) | Liposomal targeting of ischemic tissue | |
TR199701225A2 (xx) | Gen terapisi için katyonik lipidler. | |
HUP9902307A3 (en) | Novel bridged cyclic amino acids as pharmaceutical agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |