DE69829880D1 - Konjugate enthaltend zwei wirkstoffe - Google Patents

Konjugate enthaltend zwei wirkstoffe

Info

Publication number
DE69829880D1
DE69829880D1 DE69829880T DE69829880T DE69829880D1 DE 69829880 D1 DE69829880 D1 DE 69829880D1 DE 69829880 T DE69829880 T DE 69829880T DE 69829880 T DE69829880 T DE 69829880T DE 69829880 D1 DE69829880 D1 DE 69829880D1
Authority
DE
Germany
Prior art keywords
active substances
carrier
conjugate contains
linker
functional group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829880T
Other languages
English (en)
Other versions
DE69829880T2 (de
Inventor
Jane Church
Roy Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Application granted granted Critical
Publication of DE69829880D1 publication Critical patent/DE69829880D1/de
Publication of DE69829880T2 publication Critical patent/DE69829880T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69829880T 1997-11-14 1998-11-16 Konjugate enthaltend zwei wirkstoffe Expired - Lifetime DE69829880T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9724143.4A GB9724143D0 (en) 1997-11-14 1997-11-14 Pharmaceutical conjugate
GB9724143 1997-11-14
PCT/GB1998/003442 WO1999025383A1 (en) 1997-11-14 1998-11-16 Conjugates comprising two active agents

Publications (2)

Publication Number Publication Date
DE69829880D1 true DE69829880D1 (de) 2005-05-25
DE69829880T2 DE69829880T2 (de) 2005-09-22

Family

ID=10822123

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69829880T Expired - Lifetime DE69829880T2 (de) 1997-11-14 1998-11-16 Konjugate enthaltend zwei wirkstoffe

Country Status (9)

Country Link
US (1) US7001989B2 (de)
EP (1) EP1047452B1 (de)
JP (1) JP2001523648A (de)
AT (1) ATE293459T1 (de)
AU (1) AU1165899A (de)
DE (1) DE69829880T2 (de)
ES (1) ES2238774T3 (de)
GB (1) GB9724143D0 (de)
WO (1) WO1999025383A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6933366B2 (en) * 1996-12-27 2005-08-23 Tripep Ab Specificity exchangers that redirect antibodies to bacterial adhesion receptors
AU4121899A (en) * 1998-06-10 1999-12-30 Baxter Aktiengesellschaft Conjugate consisting of a lectin and a blood coagulation factor
GB9825105D0 (en) * 1998-11-16 1999-01-13 Andaris Ltd Pharamaceutical conjugates
GB9827813D0 (en) * 1998-12-17 1999-02-10 Andaris Ltd Pharmaceutical conjugates
DE19926475A1 (de) * 1999-06-10 2000-12-14 Ktb Tumorforschungs Gmbh Träger-Pharmaka-Konjugate
WO2001008709A1 (en) * 1999-07-28 2001-02-08 Valentis, Inc. Sonoporation of tumors
GB0323378D0 (en) 2003-10-07 2003-11-05 Univ Leicester Therapeutic agent
DK2019671T3 (en) 2006-05-05 2014-12-08 Univ Michigan Intermediates for the preparation of bivalent SMAC mimetics
GB0623607D0 (en) * 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
US20090170195A1 (en) * 2007-12-28 2009-07-02 Kent State University Curcumin-hyaluronan compounds
CN104059155A (zh) 2008-05-16 2014-09-24 拜耳医药保健有限公司 靶向性凝固因子及其使用方法
EP2417155B1 (de) * 2009-04-06 2013-06-19 Novo Nordisk A/S Gezielte fresetzung von faktor-viii-proteinen auf thrombozyten
GB201101740D0 (en) * 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
IL85372A (en) * 1987-02-12 1992-12-01 Us Health Penta to nona-peptides with laminin - like activity having an amino acid sequence and anti- metastatic compositions containing them
US5716614A (en) * 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
PT796090E (pt) * 1994-12-16 2003-07-31 Elan Drug Delivery Ltd Microparticulas reticuladas e sua utilizacao como veiculos terapeuticos
EP0831793A4 (de) 1995-06-06 2000-11-15 Hemosphere Inc Proteinpartikel zur therapeutischen und diagnostischen verwendung
EP1028752B1 (de) * 1996-10-21 2004-12-15 Quadrant Drug Delivery Limited Plättchen-ersatzmittel und geeignetes konjugations-herstellungsverfahren

Also Published As

Publication number Publication date
JP2001523648A (ja) 2001-11-27
DE69829880T2 (de) 2005-09-22
US20030087826A1 (en) 2003-05-08
ATE293459T1 (de) 2005-05-15
EP1047452A1 (de) 2000-11-02
US7001989B2 (en) 2006-02-21
ES2238774T3 (es) 2005-09-01
EP1047452B1 (de) 2005-04-20
AU1165899A (en) 1999-06-07
GB9724143D0 (en) 1998-01-14
WO1999025383A1 (en) 1999-05-27

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Legal Events

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