DE69826013D1 - Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin - Google Patents

Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin

Info

Publication number
DE69826013D1
DE69826013D1 DE69826013T DE69826013T DE69826013D1 DE 69826013 D1 DE69826013 D1 DE 69826013D1 DE 69826013 T DE69826013 T DE 69826013T DE 69826013 T DE69826013 T DE 69826013T DE 69826013 D1 DE69826013 D1 DE 69826013D1
Authority
DE
Germany
Prior art keywords
detecting
new generation
recombinant factor
horseshoe crab
removing endotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826013T
Other languages
English (en)
Other versions
DE69826013T2 (de
Inventor
Ling Ding
Bow Ho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National University of Singapore
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Singapore filed Critical National University of Singapore
Application granted granted Critical
Publication of DE69826013D1 publication Critical patent/DE69826013D1/de
Publication of DE69826013T2 publication Critical patent/DE69826013T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21084—Serine endopeptidases (3.4.21) limulus clotting factor C (3.4.21.84)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69826013T 1997-09-19 1998-09-18 Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin Expired - Lifetime DE69826013T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5881697P 1997-09-19 1997-09-19
US58816P 1997-09-19
US8176798A 1998-05-21 1998-05-21
US81767 1998-05-21
PCT/SG1998/000073 WO1999015676A1 (en) 1997-09-19 1998-09-18 A novel generation of cloned horseshoe crab recombinant factor c for detection and removal of endotoxin

Publications (2)

Publication Number Publication Date
DE69826013D1 true DE69826013D1 (de) 2004-10-07
DE69826013T2 DE69826013T2 (de) 2005-09-15

Family

ID=26738051

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826013T Expired - Lifetime DE69826013T2 (de) 1997-09-19 1998-09-18 Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin

Country Status (3)

Country Link
EP (1) EP1015609B1 (de)
DE (1) DE69826013T2 (de)
WO (1) WO1999015676A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6719973B1 (en) 1998-12-24 2004-04-13 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
WO2001027289A2 (en) * 1999-10-15 2001-04-19 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
BRPI0210681B8 (pt) * 2001-06-28 2021-07-27 Biowhittaker Inc métodos e reagentes para detectar endotoxina
AU2003250270B2 (en) 2002-06-24 2009-05-07 Hyglos Invest Gmbh Method for identifying and extracting endotoxin
DE102005002969A1 (de) 2005-01-21 2006-08-03 Profos Ag Verfahren zum Nachweis und zur Entfernung von Endotoxin
EP2495321A1 (de) * 2006-07-07 2012-09-05 Seikagaku Corporation Gerinnungsförderndes Enzym und Verfahren zur Detektion von Endotoxin damit
US8394602B2 (en) 2007-11-12 2013-03-12 Hiroshima University Luminescent method for measuring endotoxin
EP3273244B1 (de) * 2011-02-28 2019-09-25 Seikagaku Corporation Mittel zur messung von endotoxin
EP2740791A1 (de) * 2012-12-05 2014-06-11 MicroCoat Biotechnologie GmbH Verfahren für die rekombinante Herstellung von Pfeilschwanzkrebs-Faktor-C-Protein in Protozoen
SG11201504564TA (en) 2012-12-10 2015-08-28 Seikagaku Kogyo Co Ltd Novel recombinant factor c and method for producing the same, and method for measuring endotoxin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme

Also Published As

Publication number Publication date
WO1999015676B1 (en) 1999-05-14
DE69826013T2 (de) 2005-09-15
WO1999015676A1 (en) 1999-04-01
EP1015609B1 (de) 2004-09-01
EP1015609A1 (de) 2000-07-05

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