DE69823501D1 - Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin-abhängiger krankheiten - Google Patents
Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin-abhängiger krankheitenInfo
- Publication number
- DE69823501D1 DE69823501D1 DE69823501T DE69823501T DE69823501D1 DE 69823501 D1 DE69823501 D1 DE 69823501D1 DE 69823501 T DE69823501 T DE 69823501T DE 69823501 T DE69823501 T DE 69823501T DE 69823501 D1 DE69823501 D1 DE 69823501D1
- Authority
- DE
- Germany
- Prior art keywords
- asparaginase
- succinogenes
- asparagine
- methods
- succinogenes asparaginase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000015790 Asparaginase Human genes 0.000 title abstract 6
- 108010024976 Asparaginase Proteins 0.000 title abstract 6
- 241000605939 Wolinella succinogenes Species 0.000 title abstract 5
- 229960003272 asparaginase Drugs 0.000 title abstract 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000009145 protein modification Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4908597P | 1997-06-09 | 1997-06-09 | |
| US49085P | 1997-06-09 | ||
| PCT/US1998/011905 WO1998056410A1 (en) | 1997-06-09 | 1998-06-09 | Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69823501D1 true DE69823501D1 (de) | 2004-06-03 |
| DE69823501T2 DE69823501T2 (de) | 2005-04-07 |
Family
ID=21957977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69823501T Expired - Lifetime DE69823501T2 (de) | 1997-06-09 | 1998-06-09 | Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin-abhängiger krankheiten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6251388B1 (de) |
| EP (1) | EP0988050B1 (de) |
| AT (1) | ATE265226T1 (de) |
| AU (1) | AU752370B2 (de) |
| CA (1) | CA2295980A1 (de) |
| DE (1) | DE69823501T2 (de) |
| ES (1) | ES2217566T3 (de) |
| WO (1) | WO1998056410A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6991788B1 (en) | 1997-06-09 | 2006-01-31 | Childrens Hospital Los Angeles | Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence |
| WO1999039732A1 (en) * | 1998-02-09 | 1999-08-12 | Aventis Pharmaceuticals Products Inc. | Pharmaceutical compositions comprising peg-asparaginase for the treatment of hiv infections |
| US6689762B1 (en) | 1998-02-09 | 2004-02-10 | Enzon Pharmaceuticals, Inc. | Composition and methods for treatment of HIV infection |
| AU4030200A (en) * | 1999-04-02 | 2000-10-23 | Children's Hospital Of Los Angeles | Use of asparaginase and glutaminase to treat autoimmune disease and graft versushost disease |
| JP2003506409A (ja) * | 1999-08-06 | 2003-02-18 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | Ｈｉｖ感染の治療用組成物及び方法 |
| AU2002332371A1 (en) * | 2001-08-22 | 2003-03-10 | Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatelsky Institut Biomeditsinskoy Khimii Im. Orekhovicha | Recombinant l-asparaginase less thanigreater thanerwinia caratovoraless than/igreater than |
| EP1896524A1 (de) * | 2005-05-27 | 2008-03-12 | Formerol Limited | Handformbares material |
| NZ599631A (en) * | 2006-01-30 | 2013-08-30 | Univ Georgia State Res Found | Induction and stabilization of enzymatic activity in microorganisms |
| US7943549B2 (en) | 2007-04-02 | 2011-05-17 | Georgia State University Research Foundation, Inc. | Biological-based catalyst to delay plant development processes |
| FI20070455A0 (fi) * | 2007-06-08 | 2007-06-08 | Reagena Ltd Oy | Menetelmä syöpäsairauksien tai tulehdussairauksien hoitoon |
| WO2010023195A2 (en) | 2008-08-26 | 2010-03-04 | Kyon Biotech Ag | Compositions and methods for treating cancer |
| WO2013055699A1 (en) * | 2011-10-10 | 2013-04-18 | Children's Hospital Los Angeles | Novel asparaginase and methods for treating diseases associated with asparagine dependence |
| US10004237B2 (en) | 2013-03-14 | 2018-06-26 | Georgia State University Research Foundation, Inc. | Inhibiting or reducing fungal growth |
| US9993005B2 (en) | 2013-03-14 | 2018-06-12 | Georgia State University Research Foundation, Inc. | Preventing or delaying chill injury response in plants |
| EP3036318A1 (de) * | 2013-08-20 | 2016-06-29 | Chr. Hansen A/S | Verfahren zum wachstum von bakterienzellen |
| RU2562166C1 (ru) * | 2014-10-09 | 2015-09-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | ГИБРИДНЫЙ БЕЛОК НА ОСНОВЕ L-АСПАРАГИНАЗЫ Wolinella succinogenes, ШТАММ Escherichia coli - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА (ВАРИАНТЫ) И СПОСОБ ПОЛУЧЕНИЯ ГИБРИДНОГО БЕЛКА, ОБЛАДАЮЩЕГО ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ |
| WO2018085493A1 (en) * | 2016-11-04 | 2018-05-11 | Georgia State University Research Foundation, Inc. | Endotoxin free asparaginase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1807303A1 (de) * | 1968-11-06 | 1970-06-04 | Bayer Ag | Partiell acylierte L-Asparaginasen |
| DE2039061A1 (de) * | 1970-08-06 | 1972-02-10 | Bayer Ag | Partiell amidierte L-Asparaginasen |
| US5322678A (en) * | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
| US5693516A (en) * | 1995-11-27 | 1997-12-02 | Novo Nordisk Biotech, Inc. | Method for solubilizing proteins in organic solvents |
-
1998
- 1998-06-09 DE DE69823501T patent/DE69823501T2/de not_active Expired - Lifetime
- 1998-06-09 EP EP98932727A patent/EP0988050B1/de not_active Expired - Lifetime
- 1998-06-09 US US09/094,435 patent/US6251388B1/en not_active Expired - Lifetime
- 1998-06-09 ES ES98932727T patent/ES2217566T3/es not_active Expired - Lifetime
- 1998-06-09 AT AT98932727T patent/ATE265226T1/de not_active IP Right Cessation
- 1998-06-09 CA CA002295980A patent/CA2295980A1/en not_active Abandoned
- 1998-06-09 AU AU82544/98A patent/AU752370B2/en not_active Ceased
- 1998-06-09 WO PCT/US1998/011905 patent/WO1998056410A1/en active IP Right Grant
-
2001
- 2001-01-31 US US09/773,260 patent/US20020102251A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6251388B1 (en) | 2001-06-26 |
| AU8254498A (en) | 1998-12-30 |
| US20020102251A1 (en) | 2002-08-01 |
| WO1998056410A9 (en) | 1999-04-08 |
| EP0988050B1 (de) | 2004-04-28 |
| AU752370B2 (en) | 2002-09-19 |
| DE69823501T2 (de) | 2005-04-07 |
| EP0988050A1 (de) | 2000-03-29 |
| ES2217566T3 (es) | 2004-11-01 |
| ATE265226T1 (de) | 2004-05-15 |
| WO1998056410A1 (en) | 1998-12-17 |
| CA2295980A1 (en) | 1998-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |