ATE265226T1 - Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin- abhängiger krankheiten - Google Patents

Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin- abhängiger krankheiten

Info

Publication number
ATE265226T1
ATE265226T1 AT98932727T AT98932727T ATE265226T1 AT E265226 T1 ATE265226 T1 AT E265226T1 AT 98932727 T AT98932727 T AT 98932727T AT 98932727 T AT98932727 T AT 98932727T AT E265226 T1 ATE265226 T1 AT E265226T1
Authority
AT
Austria
Prior art keywords
asparaginase
succinogenes
asparagine
methods
succinogenes asparaginase
Prior art date
Application number
AT98932727T
Other languages
English (en)
Inventor
Donald L Durden
Original Assignee
Los Angeles Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Angeles Childrens Hospital filed Critical Los Angeles Childrens Hospital
Application granted granted Critical
Publication of ATE265226T1 publication Critical patent/ATE265226T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT98932727T 1997-06-09 1998-06-09 Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin- abhängiger krankheiten ATE265226T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4908597P 1997-06-09 1997-06-09
PCT/US1998/011905 WO1998056410A1 (en) 1997-06-09 1998-06-09 Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence

Publications (1)

Publication Number Publication Date
ATE265226T1 true ATE265226T1 (de) 2004-05-15

Family

ID=21957977

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98932727T ATE265226T1 (de) 1997-06-09 1998-06-09 Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin- abhängiger krankheiten

Country Status (8)

Country Link
US (2) US6251388B1 (de)
EP (1) EP0988050B1 (de)
AT (1) ATE265226T1 (de)
AU (1) AU752370B2 (de)
CA (1) CA2295980A1 (de)
DE (1) DE69823501T2 (de)
ES (1) ES2217566T3 (de)
WO (1) WO1998056410A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991788B1 (en) 1997-06-09 2006-01-31 Childrens Hospital Los Angeles Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence
DK1053012T3 (da) * 1998-02-09 2003-11-17 Enzon Pharmaceuticals Inc Farmaceutiske sammensætninger omfattende PEG-asparaginase til behandling af HIV-infektioner
US6689762B1 (en) 1998-02-09 2004-02-10 Enzon Pharmaceuticals, Inc. Composition and methods for treatment of HIV infection
WO2000059533A1 (en) * 1999-04-02 2000-10-12 Children's Hospital Los Angeles Use of asparaginase and glutaminase to treat autoimmune disease and graft versus host disease
AU6894400A (en) * 1999-08-06 2001-03-05 Enzon Pharmaceuticals Inc. Composition and methods for treatment of HIV infection
RU2224797C2 (ru) * 2002-04-04 2004-02-27 Эльдаров Михаил Анатольевич Рекомбинантная плазмидная днк pacyclans для переноса и экспрессии в клетках escherichia coli гена l-аспарагиназы erwinia carotovora (ecar-lans) и способ получения рекомбинантной ecar-lans из биомассы штамма e.coli-продуцента
AU2002332371A1 (en) * 2001-08-22 2003-03-10 Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatelsky Institut Biomeditsinskoy Khimii Im. Orekhovicha Recombinant l-asparaginase less thanigreater thanerwinia caratovoraless than/igreater than
JP2008542467A (ja) * 2005-05-27 2008-11-27 フォームフォームフォーム リミテッド 成形性材料
NZ570825A (en) 2006-01-30 2012-05-25 Univ Georgia State Res Found Induction and stabilization of enzymatic activity in microorganisms
US7943549B2 (en) 2007-04-02 2011-05-17 Georgia State University Research Foundation, Inc. Biological-based catalyst to delay plant development processes
FI20070455A0 (fi) * 2007-06-08 2007-06-08 Reagena Ltd Oy Menetelmä syöpäsairauksien tai tulehdussairauksien hoitoon
US8815232B2 (en) 2008-08-26 2014-08-26 Kyon Biotech Ag Compositions and methods for treating cancer
US9051561B2 (en) 2011-10-10 2015-06-09 Children's Hospital Los Angeles Asparaginase and treating diseases associated with asparagine dependence
WO2014160354A1 (en) 2013-03-14 2014-10-02 Georgia State University Research Foundation, Inc. Inhibiting or reducing fungal growth
CA2903501A1 (en) 2013-03-14 2014-10-02 Georgia State University Research Foundation, Inc. Preventing or delaying chill injury response in plants
EP3036318A1 (de) * 2013-08-20 2016-06-29 Chr. Hansen A/S Verfahren zum wachstum von bakterienzellen
RU2562166C1 (ru) * 2014-10-09 2015-09-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") ГИБРИДНЫЙ БЕЛОК НА ОСНОВЕ L-АСПАРАГИНАЗЫ Wolinella succinogenes, ШТАММ Escherichia coli - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА (ВАРИАНТЫ) И СПОСОБ ПОЛУЧЕНИЯ ГИБРИДНОГО БЕЛКА, ОБЛАДАЮЩЕГО ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ
PT3463308T (pt) 2016-06-01 2022-03-11 Servier Ip Uk Ltd Formulações de óxido de polialquileno asparaginase e métodos de fabrico e utilização do mesmo
EP3535386A4 (de) 2016-11-04 2020-04-15 Georgia State University Research Foundation, Inc. Endotoxinfreie asparaginase
US20210299233A1 (en) 2018-07-12 2021-09-30 The Children's Medical Center Corporation Method for treating cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1807303A1 (de) * 1968-11-06 1970-06-04 Bayer Ag Partiell acylierte L-Asparaginasen
DE2039061A1 (de) * 1970-08-06 1972-02-10 Bayer Ag Partiell amidierte L-Asparaginasen
US5322678A (en) * 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
US5693516A (en) * 1995-11-27 1997-12-02 Novo Nordisk Biotech, Inc. Method for solubilizing proteins in organic solvents

Also Published As

Publication number Publication date
CA2295980A1 (en) 1998-12-17
WO1998056410A1 (en) 1998-12-17
ES2217566T3 (es) 2004-11-01
AU8254498A (en) 1998-12-30
DE69823501D1 (de) 2004-06-03
DE69823501T2 (de) 2005-04-07
EP0988050B1 (de) 2004-04-28
EP0988050A1 (de) 2000-03-29
WO1998056410A9 (en) 1999-04-08
US6251388B1 (en) 2001-06-26
US20020102251A1 (en) 2002-08-01
AU752370B2 (en) 2002-09-19

Similar Documents

Publication Publication Date Title
DE69823501D1 (de) Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin-abhängiger krankheiten
EA200400312A1 (ru) АНТАГОНИСТИЧЕСКИЕ АНТИТЕЛА ПРОТИВ hTNFSF13b ЧЕЛОВЕКА
EP0259475A4 (de) Rekombinanter menschlicher endothelzellenwachstumsfaktor.
ATE383865T1 (de) Apolipoprotein a-i agonisten und deren verwendung zur behandlung dyslipidämischer erkrankungen
CY1111120T1 (el) Πεπτιδια που παραγονται απο πρωτεϊνες νευρικων ινων και η ιατρικη τους χρηση
ES8602121A1 (es) Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana
DE69131961D1 (de) Für die reinigung bestimmte klonierung von peptiden
IL147293A0 (en) Peptides that lower blood glucose levels
HUP0102257A2 (hu) Módosított K-vitamin-dependens polipeptidek
DE60331546D1 (de) Verwendung von aspartic proteasen in den bereichen kosmetik und behandlung
SE8902532D0 (sv) Bestaemning av plasmaproteiner
ATE320488T1 (de) Mutanten des lag-3 proteins, ihre expression und verwendung
BR9810701A (pt) Proteìna "swollenina" de trichoderma reesei e seqâências de codificação de dna
NZ515678A (en) Human GIL-19/AE289 proteins and polynucleotides encoding same
ATE153069T1 (de) Vektoren und zusammensetzungen zur expression von glykosilationsmutanten des menschlichen proteins- c
DE60139515D1 (de) Neue Polypeptide aus Bienengift und dessen Gebrauchsverfahren
DE69013011D1 (de) Bcrf1-proteine als inhibitoren von interferon-g(g).
BR9007115A (pt) Novo trombolitico
ATE374246T1 (de) Polypeptidfragmente mit einem c-terminalen teil von katalase aus helicobacter
ATE310828T1 (de) Implantat und vektor zur behandlung von erworbenen krankheiten
WO2000063415A8 (en) Dna encoding the human vanilloid receptor vr1
DE60132571D1 (de) Für den menschlichen vanilloid-rezeptor vr3 kodierende dns
EA200401390A1 (ru) N-ацетилглюкозамин-6-фосфатдеацетилаза человека, взаимодействующая с каспазой-8, и способы ее применения
ES8802441A1 (es) Procedimiento para preparar laminina humana
HUP9900789A2 (hu) Lefelé irányuló szabályozásra rezisztens C3 konvertáz

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties