DE69809057T2 - Process for the preparation of 1,3-diaza-spiro [4.4] non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates - Google Patents

Process for the preparation of 1,3-diaza-spiro [4.4] non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates

Info

Publication number
DE69809057T2
DE69809057T2 DE69809057T DE69809057T DE69809057T2 DE 69809057 T2 DE69809057 T2 DE 69809057T2 DE 69809057 T DE69809057 T DE 69809057T DE 69809057 T DE69809057 T DE 69809057T DE 69809057 T2 DE69809057 T2 DE 69809057T2
Authority
DE
Germany
Prior art keywords
formula
compound
preparation
transformed
reaction medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69809057T
Other languages
English (en)
Other versions
DE69809057D1 (de
Inventor
Attila Kis-Tamas
Csaba Huszar
Bertrand Castro
Attila Nemeth
Peter Aranyosi
Karoly Gyuere
Istvan Meszaros
Zrinyi Ilona Dervalicsne
Katalin Dubovszki
Lajosne Pali
Antal Gajari
Attila Supic
Zsuzsanna Nad
Zoltan Makovi
Endre Kollar
Hari Zsuzsanna Csetrin
Karasz Agnes Kunsztn
Erzsebet Bognar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of DE69809057D1 publication Critical patent/DE69809057D1/de
Publication of DE69809057T2 publication Critical patent/DE69809057T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69809057T 1997-07-25 1998-07-22 Process for the preparation of 1,3-diaza-spiro [4.4] non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates Expired - Lifetime DE69809057T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9701294A HU218681B (hu) 1997-07-25 1997-07-25 Eljárás 1,3-diaza-spiro(4,4)non-1-én-4-on-származékok előállitására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
PCT/HU1998/000067 WO1999005119A1 (en) 1997-07-25 1998-07-22 Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates

Publications (2)

Publication Number Publication Date
DE69809057D1 DE69809057D1 (de) 2002-12-05
DE69809057T2 true DE69809057T2 (de) 2003-08-14

Family

ID=89995419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809057T Expired - Lifetime DE69809057T2 (de) 1997-07-25 1998-07-22 Process for the preparation of 1,3-diaza-spiro [4.4] non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates

Country Status (8)

Country Link
US (1) US6239286B1 (de)
EP (1) EP0998462B1 (de)
AT (1) ATE226942T1 (de)
AU (1) AU8553698A (de)
DE (1) DE69809057T2 (de)
ES (1) ES2187987T3 (de)
HU (1) HU218681B (de)
WO (1) WO1999005119A1 (de)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ237476A (en) 1990-03-20 1994-01-26 Sanofi Sa N-substituted heterocyclic compounds and pharmaceutical compositions.
FR2681067B1 (fr) * 1991-09-10 1993-12-17 Elf Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
US5541209A (en) 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
US6075055A (en) * 1995-05-31 2000-06-13 Kumiai Chemical Industry Co., Ltd. Phenylalkane amide derivatives and agricultural or horticultural fungicides
CA2196263C (en) * 1996-02-09 2004-10-26 Barry Jackson Process for the preparation of 4-oxoimidazolinium salts
TR199801990T2 (xx) * 1996-04-02 2000-06-21 Bayer Aktiengesellschaft Yeni ikameli fenilketoenoller.
DE19912383A1 (de) * 1998-03-27 1999-09-30 Degussa Verfahren zur Herstellung von cyclischen 4-Oxoamidinen
US5910595A (en) * 1998-06-26 1999-06-08 Salsbury Chemicals, Inc. Process for preparing oximidazoles

Also Published As

Publication number Publication date
DE69809057D1 (de) 2002-12-05
AU8553698A (en) 1999-02-16
ATE226942T1 (de) 2002-11-15
EP0998462B1 (de) 2002-10-30
HU218681B (hu) 2000-10-30
HU9701294D0 (en) 1997-09-29
ES2187987T3 (es) 2003-06-16
US6239286B1 (en) 2001-05-29
EP0998462A1 (de) 2000-05-10
HU218681A (en) 2000-10-28
WO1999005119A1 (en) 1999-02-04

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