DE69802171D1 - Verfahren zur herstellung von 10,11-dihydro-5h-dibenzo(a,d)cyclohept-5-enen und ihren derivaten - Google Patents
Verfahren zur herstellung von 10,11-dihydro-5h-dibenzo(a,d)cyclohept-5-enen und ihren derivatenInfo
- Publication number
- DE69802171D1 DE69802171D1 DE69802171T DE69802171T DE69802171D1 DE 69802171 D1 DE69802171 D1 DE 69802171D1 DE 69802171 T DE69802171 T DE 69802171T DE 69802171 T DE69802171 T DE 69802171T DE 69802171 D1 DE69802171 D1 DE 69802171D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclohept
- dibenzo
- dihydro
- enen
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HQGYGGZHZWXFSI-UHFFFAOYSA-N 1,4-cycloheptadiene Chemical compound C1CC=CCC=C1 HQGYGGZHZWXFSI-UHFFFAOYSA-N 0.000 title 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 abstract 1
- 229960003088 loratadine Drugs 0.000 abstract 1
- 229910052719 titanium Inorganic materials 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703992.9A GB9703992D0 (en) | 1997-02-26 | 1997-02-26 | Process |
| GB9703992 | 1997-02-26 | ||
| PCT/GB1998/000605 WO1998038166A1 (en) | 1997-02-26 | 1998-02-26 | Process for the preparation of 10,11-dihydro-5h-dibenzo[a,d]cyclohept-5-enes and derivatives thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DE69802171D1 true DE69802171D1 (de) | 2001-11-29 |
| DE69802171T2 DE69802171T2 (de) | 2002-07-04 |
| DE69802171T8 DE69802171T8 (de) | 2009-10-08 |
| DE69802171T3 DE69802171T3 (de) | 2010-07-08 |
Family
ID=10808344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69802171T Expired - Lifetime DE69802171T3 (de) | 1997-02-26 | 1998-02-26 | Verfahren zur Herstellung von 5,6-Dihydro-11H-dibenzo[a,d]cyclohept-11-enen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6093827A (de) |
| EP (1) | EP0970050B2 (de) |
| AT (1) | ATE207466T1 (de) |
| AU (1) | AU6304798A (de) |
| CA (1) | CA2282480C (de) |
| DE (1) | DE69802171T3 (de) |
| DK (1) | DK0970050T4 (de) |
| ES (1) | ES2149737T5 (de) |
| GB (1) | GB9703992D0 (de) |
| WO (1) | WO1998038166A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703992D0 (en) * | 1997-02-26 | 1997-04-16 | Rolabo Sl | Process |
| JP6105585B2 (ja) | 2011-08-16 | 2017-03-29 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗腫瘍剤としての三環式化合物 |
| CN112552230B (zh) * | 2020-12-11 | 2022-08-26 | 佛山普正医药科技有限公司 | 一种盐酸赛庚啶的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3905972A (en) * | 1970-10-09 | 1975-09-16 | Hoffmann La Roche | Tricyclic imines |
| FR2266676B1 (de) * | 1974-04-05 | 1980-04-04 | Univ California | |
| DE2641075C2 (de) * | 1975-09-29 | 1985-11-14 | The Regents Of The University Of California, Berkeley, Calif. | Verfahren zur Herstellung von symmetrischen Olefinen |
| EP0126470B1 (de) † | 1983-05-19 | 1989-04-12 | Bristol-Myers Company | Verfahren zur Herstellung von Tamoxifen |
| GB9703992D0 (en) † | 1997-02-26 | 1997-04-16 | Rolabo Sl | Process |
| CH688412A5 (de) † | 1997-03-11 | 1997-09-15 | Cilag Ag | Verfahren zur Herstellung von 1,4-disubstituierten Piperidinverbindungen. |
| US6084100A (en) † | 1997-05-30 | 2000-07-04 | Medichem, S.A. | Process for the preparation of loratadine |
-
1997
- 1997-02-26 GB GBGB9703992.9A patent/GB9703992D0/en active Pending
-
1998
- 1998-02-26 DK DK98907067.7T patent/DK0970050T4/da active
- 1998-02-26 WO PCT/GB1998/000605 patent/WO1998038166A1/en active IP Right Grant
- 1998-02-26 CA CA002282480A patent/CA2282480C/en not_active Expired - Fee Related
- 1998-02-26 EP EP98907067A patent/EP0970050B2/de not_active Expired - Lifetime
- 1998-02-26 AT AT98907067T patent/ATE207466T1/de not_active IP Right Cessation
- 1998-02-26 AU AU63047/98A patent/AU6304798A/en not_active Abandoned
- 1998-02-26 DE DE69802171T patent/DE69802171T3/de not_active Expired - Lifetime
- 1998-02-26 ES ES98907067T patent/ES2149737T5/es not_active Expired - Lifetime
-
1999
- 1999-08-26 US US09/383,078 patent/US6093827A/en not_active Expired - Lifetime
-
2000
- 2000-03-15 US US09/525,894 patent/US7282587B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2149737T5 (es) | 2009-12-14 |
| EP0970050B1 (de) | 2001-10-24 |
| US7282587B1 (en) | 2007-10-16 |
| CA2282480C (en) | 2002-04-23 |
| DE69802171T8 (de) | 2009-10-08 |
| GB9703992D0 (en) | 1997-04-16 |
| DE69802171T2 (de) | 2002-07-04 |
| DK0970050T3 (da) | 2002-02-11 |
| ATE207466T1 (de) | 2001-11-15 |
| ES2149737T3 (es) | 2001-12-16 |
| DE69802171T3 (de) | 2010-07-08 |
| CA2282480A1 (en) | 1998-09-03 |
| EP0970050A1 (de) | 2000-01-12 |
| DK0970050T4 (da) | 2010-03-01 |
| US6093827A (en) | 2000-07-25 |
| AU6304798A (en) | 1998-09-18 |
| ES2149737T1 (es) | 2000-11-16 |
| WO1998038166A1 (en) | 1998-09-03 |
| EP0970050B2 (de) | 2009-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings | ||
| 8332 | No legal effect for de | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803 |