DE69739964D1 - Verwendung von alkyltransferasen zur gentherapie uungsmitteln zu schützen - Google Patents

Verwendung von alkyltransferasen zur gentherapie uungsmitteln zu schützen

Info

Publication number
DE69739964D1
DE69739964D1 DE69739964T DE69739964T DE69739964D1 DE 69739964 D1 DE69739964 D1 DE 69739964D1 DE 69739964 T DE69739964 T DE 69739964T DE 69739964 T DE69739964 T DE 69739964T DE 69739964 D1 DE69739964 D1 DE 69739964D1
Authority
DE
Germany
Prior art keywords
gene therapy
neoplastic
combination
regime
agt protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739964T
Other languages
English (en)
Inventor
Anthony E Pegg
Stanton L Gerson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Penn State Research Foundation
Original Assignee
Case Western Reserve University
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University, Penn State Research Foundation filed Critical Case Western Reserve University
Application granted granted Critical
Publication of DE69739964D1 publication Critical patent/DE69739964D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69739964T 1996-03-25 1997-03-25 Verwendung von alkyltransferasen zur gentherapie uungsmitteln zu schützen Expired - Lifetime DE69739964D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/620,969 US5965126A (en) 1996-03-25 1996-03-25 use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents
PCT/US1997/004917 WO1997035477A1 (en) 1996-03-25 1997-03-25 Use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents

Publications (1)

Publication Number Publication Date
DE69739964D1 true DE69739964D1 (de) 2010-09-30

Family

ID=24488165

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739964T Expired - Lifetime DE69739964D1 (de) 1996-03-25 1997-03-25 Verwendung von alkyltransferasen zur gentherapie uungsmitteln zu schützen

Country Status (8)

Country Link
US (1) US5965126A (de)
EP (1) EP0910246B1 (de)
JP (1) JP2000507554A (de)
AT (1) ATE477815T1 (de)
AU (1) AU2548197A (de)
DE (1) DE69739964D1 (de)
ES (1) ES2355677T3 (de)
WO (1) WO1997035477A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US20040022838A1 (en) * 2001-06-20 2004-02-05 Holick Michael F. Regulation of cell proliferation and differentiation using topically applied peptides
US9682106B2 (en) 2011-04-20 2017-06-20 The Regents Of The University Of California Method for combined conditioning and chemoselection in a single cycle
WO2012145723A1 (en) 2011-04-20 2012-10-26 The Regents Of The University Of California Method for combined conditioning and chemoselection in a single cycle
EP3227317A4 (de) * 2014-12-02 2018-04-25 Roger Williams Hospital Verfahren und zusammensetzungen zur behandlung von krebs
US10426798B2 (en) 2017-07-18 2019-10-01 Calimmune, Inc. Modulatable switch for selection of donor modified cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091430A (en) * 1990-03-13 1992-02-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services O6 -substituted guanine compounds and methods for depleting O6 -alkylguanine-DNA alkyltransferase levels
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
AU656544B2 (en) * 1990-10-31 1995-02-09 Brigham And Women's Hospital Genetic modification of endothelial cells
US5637483A (en) * 1991-10-04 1997-06-10 Whitehead Institute For Biomedical Research Irradiated tumor cell vaccine engineered to express GM-CSF

Also Published As

Publication number Publication date
WO1997035477A1 (en) 1997-10-02
ATE477815T1 (de) 2010-09-15
AU2548197A (en) 1997-10-17
JP2000507554A (ja) 2000-06-20
US5965126A (en) 1999-10-12
EP0910246A1 (de) 1999-04-28
EP0910246B1 (de) 2010-08-18
EP0910246A4 (de) 2003-07-02
ES2355677T3 (es) 2011-03-30

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DE69739964D1 (de) Verwendung von alkyltransferasen zur gentherapie uungsmitteln zu schützen
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