DE69737749D1 - (-)-8-Ä(4-Amino-1-methylbutyl)aminoÜ-5-(3,4-dichlorophenoxy)-6-methoxy-4-methylchinolin-enthaltendes Medikament zur Behandlung parasitärer und opportunistischer Infektionen - Google Patents
(-)-8-Ä(4-Amino-1-methylbutyl)aminoÜ-5-(3,4-dichlorophenoxy)-6-methoxy-4-methylchinolin-enthaltendes Medikament zur Behandlung parasitärer und opportunistischer InfektionenInfo
- Publication number
- DE69737749D1 DE69737749D1 DE69737749T DE69737749T DE69737749D1 DE 69737749 D1 DE69737749 D1 DE 69737749D1 DE 69737749 T DE69737749 T DE 69737749T DE 69737749 T DE69737749 T DE 69737749T DE 69737749 D1 DE69737749 D1 DE 69737749D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- methylquinoline
- dichlorophenoxy
- methylbutyl
- parasitic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000030852 Parasitic disease Diseases 0.000 title abstract 3
- AYLJCADJMBGDFO-UHFFFAOYSA-N CC1=C2C(=NC(=C1C(C)CCCN)N)C=CC(=C2OC3=CC(=C(C=C3)Cl)Cl)OC Chemical compound CC1=C2C(=NC(=C1C(C)CCCN)N)C=CC(=C2OC3=CC(=C(C=C3)Cl)Cl)OC AYLJCADJMBGDFO-UHFFFAOYSA-N 0.000 title 1
- 208000001388 Opportunistic Infections Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000003071 parasitic effect Effects 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 3
- WREVVZMUNPAPOV-UHFFFAOYSA-N 8-aminoquinoline Chemical compound C1=CN=C2C(N)=CC=CC2=C1 WREVVZMUNPAPOV-UHFFFAOYSA-N 0.000 abstract 1
- 150000005012 8-aminoquinolines Chemical class 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- -1 tri-substituted phenoxy Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1429296P | 1996-03-29 | 1996-03-29 | |
| US14292P | 1996-03-29 | ||
| PCT/US1997/005160 WO1997036590A1 (en) | 1996-03-29 | 1997-03-28 | 8-aminoquinolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69737749D1 true DE69737749D1 (de) | 2007-07-05 |
| DE69737749T2 DE69737749T2 (de) | 2008-01-31 |
Family
ID=21764604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737749T Expired - Fee Related DE69737749T2 (de) | 1996-03-29 | 1997-03-28 | (-)-8-Ä(4-Amino-1-methylbutyl)aminoÜ-5-(3,4-dichlorophenoxy)-6-methoxy-4-methylchinolin-enthaltendes Medikament zur Behandlung parasitärer und opportunistischer Infektionen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6376511B2 (de) |
| EP (1) | EP0907363B1 (de) |
| AT (1) | ATE362762T1 (de) |
| AU (1) | AU729992B2 (de) |
| CA (1) | CA2250501C (de) |
| DE (1) | DE69737749T2 (de) |
| DK (1) | DK0907363T3 (de) |
| ES (1) | ES2284184T3 (de) |
| NZ (1) | NZ332197A (de) |
| PT (1) | PT907363E (de) |
| WO (1) | WO1997036590A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210150D0 (en) | 2002-05-03 | 2002-06-12 | Smithkline Beecham Plc | Process |
| US6949250B2 (en) * | 2002-12-16 | 2005-09-27 | The United States Of America As Represented By The Secretary Of Agriculture | Selective algaecides for control of cyanochloronta |
| WO2007127930A2 (en) * | 2006-04-28 | 2007-11-08 | Kansas State University Research Foundation | Compounds affecting gap junction activity |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB834300A (en) * | 1957-03-22 | 1960-05-04 | Wellcome Found | Improvements in and relating to quinoline derivatives and the manufacture thereof |
| US4209519A (en) * | 1978-03-13 | 1980-06-24 | The United States Of America As Represented By The Secretary Of The Army | Anti-leishmanial lepidine derivatives |
| US4431807A (en) * | 1980-06-12 | 1984-02-14 | The United States Of America As Represented By The Secretary Of The Army | 4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines |
| US4659708A (en) * | 1980-09-02 | 1987-04-21 | The United States Of America As Represented By The Secretary Of The Army | Anti-leishmanial lepidine derivatives |
| US4554279A (en) * | 1981-01-29 | 1985-11-19 | The United States Of America As Represented By The Secretary Of The Army | 5-(Straight chain 3-12 carbon alkoxy)-8-quinolinamines and their use for treatment of malaria |
| US4617394A (en) * | 1985-10-15 | 1986-10-14 | The United States Of America As Represented By The Secretary Of The Army | 4-methyl-5-(unsubstituted and substituted phenoxy)-2,6-dimethoxy-8-(aminoalkylamino) quinolines |
| FR2612778B1 (fr) * | 1987-03-24 | 1991-10-18 | Ire Cell Targ Sa | Nouveaux derives d'aminoquinoleine antimalarique, procede de preparation et composition pharmaceutique en contenant |
| FR2644462B1 (fr) * | 1988-09-23 | 1993-07-09 | Ire Celltarg Sa | Nouveaux composes actifs sur les formes tissulaires de la malaria et procede de preparation |
| US4980360A (en) * | 1990-03-13 | 1990-12-25 | Calspan Corporation | 5-(phenylalkoxy)primaquine compounds and their use for treatment of malaria |
| US5104885A (en) * | 1990-03-13 | 1992-04-14 | Calspan Corporation | 5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine compounds and their use for treatment of malaria |
-
1997
- 1997-03-28 EP EP97917709A patent/EP0907363B1/de not_active Expired - Lifetime
- 1997-03-28 AU AU25966/97A patent/AU729992B2/en not_active Expired
- 1997-03-28 PT PT97917709T patent/PT907363E/pt unknown
- 1997-03-28 US US09/155,509 patent/US6376511B2/en not_active Expired - Lifetime
- 1997-03-28 DK DK97917709T patent/DK0907363T3/da active
- 1997-03-28 WO PCT/US1997/005160 patent/WO1997036590A1/en active IP Right Grant
- 1997-03-28 ES ES97917709T patent/ES2284184T3/es not_active Expired - Lifetime
- 1997-03-28 DE DE69737749T patent/DE69737749T2/de not_active Expired - Fee Related
- 1997-03-28 NZ NZ332197A patent/NZ332197A/en not_active IP Right Cessation
- 1997-03-28 CA CA002250501A patent/CA2250501C/en not_active Expired - Fee Related
- 1997-03-28 AT AT97917709T patent/ATE362762T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU729992B2 (en) | 2001-02-22 |
| DE69737749T2 (de) | 2008-01-31 |
| US20010007031A1 (en) | 2001-07-05 |
| EP0907363A4 (de) | 2005-04-06 |
| WO1997036590A1 (en) | 1997-10-09 |
| ES2284184T3 (es) | 2007-11-01 |
| PT907363E (pt) | 2007-06-08 |
| AU2596697A (en) | 1997-10-22 |
| NZ332197A (en) | 2000-06-23 |
| CA2250501C (en) | 2007-11-13 |
| EP0907363A1 (de) | 1999-04-14 |
| US6376511B2 (en) | 2002-04-23 |
| CA2250501A1 (en) | 1997-10-09 |
| EP0907363B1 (de) | 2007-05-23 |
| ATE362762T1 (de) | 2007-06-15 |
| DK0907363T3 (da) | 2007-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |