DE69737298D1 - Konjugate von polysacchariden und biomolekülen - Google Patents

Konjugate von polysacchariden und biomolekülen

Info

Publication number
DE69737298D1
DE69737298D1 DE69737298T DE69737298T DE69737298D1 DE 69737298 D1 DE69737298 D1 DE 69737298D1 DE 69737298 T DE69737298 T DE 69737298T DE 69737298 T DE69737298 T DE 69737298T DE 69737298 D1 DE69737298 D1 DE 69737298D1
Authority
DE
Germany
Prior art keywords
biomolecules
conjugates
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737298T
Other languages
English (en)
Other versions
DE69737298T2 (de
Inventor
Harshvardhan Mehta
Rajendra Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Publication of DE69737298D1 publication Critical patent/DE69737298D1/de
Application granted granted Critical
Publication of DE69737298T2 publication Critical patent/DE69737298T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
DE69737298T 1997-08-08 1997-08-08 Konjugate von polysacchariden und biomolekülen Expired - Lifetime DE69737298T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/013803 WO1999007744A1 (en) 1997-08-08 1997-08-08 Polysaccharide conjugates of biomolecules

Publications (2)

Publication Number Publication Date
DE69737298D1 true DE69737298D1 (de) 2007-03-15
DE69737298T2 DE69737298T2 (de) 2007-06-28

Family

ID=22261398

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737298T Expired - Lifetime DE69737298T2 (de) 1997-08-08 1997-08-08 Konjugate von polysacchariden und biomolekülen

Country Status (6)

Country Link
EP (1) EP0961783B1 (de)
JP (1) JP4182269B2 (de)
CA (1) CA2266718C (de)
DE (1) DE69737298T2 (de)
ES (1) ES2279544T3 (de)
WO (1) WO1999007744A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9597198A (en) 1997-10-03 1999-04-27 Galenica Pharmaceuticals, Inc. Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants
EP1574217A1 (de) * 1997-10-03 2005-09-14 Galenica Pharmaceuticals, Inc. Iminbildende Polysaccharide, deren Herstellung und Verwendung als Zusatzmittel und Immunstimulierende Mittel
EP1132739B1 (de) * 2000-05-16 2001-09-26 BioChip Technologies GmbH Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung
GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
WO2006042161A2 (en) 2004-10-07 2006-04-20 E.I. Dupont De Nemours And Company Polysaccharide-based polymer tissue adhesive for medical use
US7172906B2 (en) * 2004-11-16 2007-02-06 Dade Behring Inc. Reduction of non-specific binding in assays
CN101443044A (zh) * 2005-09-22 2009-05-27 哈达斯特医学研究服务与开发有限公司 治疗活性化合物的葡聚糖和阿拉伯半乳聚糖结合物
WO2007058654A1 (en) * 2005-11-17 2007-05-24 Siemens Healthcare Diagnostics Inc. Reduction of non-specific binding in assays
JP5539725B2 (ja) 2006-11-27 2014-07-02 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー 分岐末端反応物及びそれから製造されるポリマーヒドロゲル組織接着剤
EP2214731B1 (de) 2007-11-14 2014-05-14 Actamax Surgical Materials LLC Auf oxidiertem kationischem polysaccharid basierendes polymergewebehaftmittel zur medizinischen verwendung
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
US9044529B2 (en) 2008-11-19 2015-06-02 Actamax Surgical Materials, Llc Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
WO2010118284A1 (en) 2009-04-09 2010-10-14 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having reduced degradation time
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011002888A2 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive for medical use
US8580951B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
WO2015017340A2 (en) 2013-07-29 2015-02-05 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2223618A1 (de) * 1971-06-14 1973-01-04 Akad Wissenschaften Ddr Verfahren zur herstellung von in wasser loeslichen kupplungsprodukten aminogruppenhaltiger biologisch-aktiver verbindungen mit carbonylgruppenhaltigen polymeren

Also Published As

Publication number Publication date
EP0961783B1 (de) 2007-01-24
JP4182269B2 (ja) 2008-11-19
JP2001516394A (ja) 2001-09-25
EP0961783A1 (de) 1999-12-08
DE69737298T2 (de) 2007-06-28
CA2266718C (en) 2007-05-22
WO1999007744A1 (en) 1999-02-18
ES2279544T3 (es) 2007-08-16
CA2266718A1 (en) 1999-02-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH, , DE