DE69733207D1 - Verfahren zur hemmung von eif5a-biosynthese - Google Patents

Verfahren zur hemmung von eif5a-biosynthese

Info

Publication number
DE69733207D1
DE69733207D1 DE69733207T DE69733207T DE69733207D1 DE 69733207 D1 DE69733207 D1 DE 69733207D1 DE 69733207 T DE69733207 T DE 69733207T DE 69733207 T DE69733207 T DE 69733207T DE 69733207 D1 DE69733207 D1 DE 69733207D1
Authority
DE
Germany
Prior art keywords
polyamine
alkyl
biosynthesis
intracellular
eif
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69733207T
Other languages
English (en)
Other versions
DE69733207T2 (de
Inventor
J Bergeron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Application granted granted Critical
Publication of DE69733207D1 publication Critical patent/DE69733207D1/de
Publication of DE69733207T2 publication Critical patent/DE69733207T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69733207T 1996-09-13 1997-09-12 Verfahren zur hemmung von elf5a-biosynthese Expired - Fee Related DE69733207T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2589696P 1996-09-13 1996-09-13
US25896P 1996-09-13
PCT/US1997/015909 WO1998010766A1 (en) 1996-09-13 1997-09-12 METHOD OF INHIBITING BIOSYNTHESIS OF EIf5A

Publications (2)

Publication Number Publication Date
DE69733207D1 true DE69733207D1 (de) 2005-06-09
DE69733207T2 DE69733207T2 (de) 2006-02-02

Family

ID=21828649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733207T Expired - Fee Related DE69733207T2 (de) 1996-09-13 1997-09-12 Verfahren zur hemmung von elf5a-biosynthese

Country Status (8)

Country Link
US (1) US6274630B1 (de)
EP (4) EP1459747A3 (de)
JP (1) JP3470901B2 (de)
AT (1) ATE294583T1 (de)
AU (1) AU733866B2 (de)
CA (1) CA2264745C (de)
DE (1) DE69733207T2 (de)
WO (1) WO1998010766A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060471A (en) * 1998-01-21 2000-05-09 Styczynski; Peter Reduction of hair growth
US6794545B1 (en) * 1999-04-30 2004-09-21 Slil Biomedical Corporation Conformationally restricted polyamine analogs as disease therapies
WO2003033455A1 (en) * 2001-10-16 2003-04-24 Slil Biomedical Corporation Oligoamine compounds and derivatives thereof for cancer therapy
US6458795B1 (en) * 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
WO2004078940A2 (en) * 2003-03-05 2004-09-16 Senesco Technologies, Inc. USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1
WO2005041988A1 (en) * 2003-10-22 2005-05-12 University Of Florida Method and composition for pain amelioration
CN101300004B (zh) * 2005-09-23 2013-08-21 帕瑟洛吉卡有限公司 使用多胺类似物治疗病毒感染的方法
NZ628513A (en) 2009-07-16 2016-01-29 Pathologica Llc Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
CN105163730B (zh) 2013-01-08 2018-10-30 帕萨罗杰卡有限公司 用于治疗脱髓鞘疾病的方法和组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491583A (en) * 1970-08-07 1985-01-01 Pfizer Inc. Interferon induction in animals by amines
US5393757A (en) * 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
CA2094341A1 (en) * 1992-04-28 1993-10-29 Carl W. Porter Methods for the use of spermidine/spermine n1-acetyltransferase as a prognostic indicator and/or tumor response marker
US5344846A (en) * 1992-12-30 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
US5541230A (en) * 1993-11-05 1996-07-30 Us Health Therapeutic polyamines
US5510390A (en) * 1994-01-28 1996-04-23 University Of Florida Research Foundation, Inc. Anti-hypertensive composition and methods of treatment
US5516807A (en) * 1994-10-25 1996-05-14 Warner-Lambert Company Method for treating vascular proliferative disorders following balloon angioplasty
US5962533A (en) * 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines

Also Published As

Publication number Publication date
EP0946177A1 (de) 1999-10-06
ATE294583T1 (de) 2005-05-15
AU6078298A (en) 1998-04-02
EP1459744A3 (de) 2004-12-15
CA2264745C (en) 2003-11-11
EP1459747A3 (de) 2004-12-15
US6274630B1 (en) 2001-08-14
DE69733207T2 (de) 2006-02-02
AU733866B2 (en) 2001-05-31
EP1459745A3 (de) 2004-12-15
JP2000505808A (ja) 2000-05-16
EP1459744A2 (de) 2004-09-22
EP0946177A4 (de) 2000-04-19
JP3470901B2 (ja) 2003-11-25
EP0946177B1 (de) 2005-05-04
CA2264745A1 (en) 1998-03-19
EP1459745A2 (de) 2004-09-22
EP1459747A2 (de) 2004-09-22
WO1998010766A1 (en) 1998-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee