DE69721077D1 - Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung - Google Patents

Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung

Info

Publication number
DE69721077D1
DE69721077D1 DE69721077T DE69721077T DE69721077D1 DE 69721077 D1 DE69721077 D1 DE 69721077D1 DE 69721077 T DE69721077 T DE 69721077T DE 69721077 T DE69721077 T DE 69721077T DE 69721077 D1 DE69721077 D1 DE 69721077D1
Authority
DE
Germany
Prior art keywords
methyl
methoxyphenyl
production
hypersecretion
ignitant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69721077T
Other languages
English (en)
Other versions
DE69721077T2 (de
Inventor
Sergio Anzalone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medosan Ricerca Srl
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Medosan Ricerca Srl
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medosan Ricerca Srl, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Medosan Ricerca Srl
Publication of DE69721077D1 publication Critical patent/DE69721077D1/de
Application granted granted Critical
Publication of DE69721077T2 publication Critical patent/DE69721077T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69721077T 1997-08-08 1997-08-08 Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung Expired - Lifetime DE69721077T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT1997/000209 WO1999007363A1 (en) 1997-08-08 1997-08-08 Use of the compound 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate for the production of an anti-inflammatory drug with prevention of gastric hypersecretion and renal impairment

Publications (2)

Publication Number Publication Date
DE69721077D1 true DE69721077D1 (de) 2003-05-22
DE69721077T2 DE69721077T2 (de) 2004-02-05

Family

ID=11332729

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69721077T Expired - Lifetime DE69721077T2 (de) 1997-08-08 1997-08-08 Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung

Country Status (6)

Country Link
EP (1) EP1024807B1 (de)
JP (1) JP2001513497A (de)
AT (1) ATE237326T1 (de)
DE (1) DE69721077T2 (de)
DK (1) DK1024807T3 (de)
WO (1) WO1999007363A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1297140B1 (it) 1997-12-24 1999-08-03 Sigma Tau Ind Farmaceuti Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
IT1302898B1 (it) 1998-12-03 2000-10-10 Medosan Ricerca Srl Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali.
DE602004029993D1 (de) * 2003-02-27 2010-12-23 Eisai R&D Man Co Ltd Pharmazeutische zusammensetzung zur behandlung von drogenabhängigkeit
CN100390144C (zh) * 2006-03-29 2008-05-28 安徽省庆云医药化工有限公司 1-甲基-5-对甲苯酰吡咯-2-乙酰氨基乙酸愈创木酚酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1162856A (en) * 1981-07-20 1984-02-28 Dushan M. Dvornik Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5- methoxy-2-methyl-1h-indole-3-acetic acid
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.

Also Published As

Publication number Publication date
EP1024807A1 (de) 2000-08-09
WO1999007363A1 (en) 1999-02-18
JP2001513497A (ja) 2001-09-04
DE69721077T2 (de) 2004-02-05
EP1024807B1 (de) 2003-04-16
DK1024807T3 (da) 2003-08-04
ATE237326T1 (de) 2003-05-15

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