DE69705114T2 - 4-[(thien-2-yl)methyl]imidazolderivate mit alpha2-adrenoceptor agonistischer aktivität - Google Patents
4-[(thien-2-yl)methyl]imidazolderivate mit alpha2-adrenoceptor agonistischer aktivitätInfo
- Publication number
- DE69705114T2 DE69705114T2 DE69705114T DE69705114T DE69705114T2 DE 69705114 T2 DE69705114 T2 DE 69705114T2 DE 69705114 T DE69705114 T DE 69705114T DE 69705114 T DE69705114 T DE 69705114T DE 69705114 T2 DE69705114 T2 DE 69705114T2
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- thien
- imidazole derivatives
- agonistic activity
- adrenoceptor agonistic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WJTRJFZWODRGDQ-UHFFFAOYSA-N 5-(thiophen-2-ylmethyl)-1h-imidazole Chemical class C=1C=CSC=1CC1=CNC=N1 WJTRJFZWODRGDQ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001270 agonistic effect Effects 0.000 title 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/625,447 US5621113A (en) | 1996-03-28 | 1996-03-28 | 4-[(thien-2-yl)methyl]-imidazole analgesics |
PCT/US1997/004768 WO1997035857A1 (en) | 1996-03-28 | 1997-03-26 | 4-[(thien-2-yl)methyl]imidazole derivatives having alpha2-adrenoceptor agonistic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69705114D1 DE69705114D1 (de) | 2001-07-12 |
DE69705114T2 true DE69705114T2 (de) | 2001-10-18 |
Family
ID=24506117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69705114T Expired - Lifetime DE69705114T2 (de) | 1996-03-28 | 1997-03-26 | 4-[(thien-2-yl)methyl]imidazolderivate mit alpha2-adrenoceptor agonistischer aktivität |
Country Status (16)
Country | Link |
---|---|
US (1) | US5621113A (de) |
EP (1) | EP0889891B1 (de) |
JP (1) | JP4018145B2 (de) |
AT (1) | ATE201869T1 (de) |
AU (1) | AU718719B2 (de) |
CA (1) | CA2250929C (de) |
DE (1) | DE69705114T2 (de) |
DK (1) | DK0889891T3 (de) |
ES (1) | ES2159857T3 (de) |
GR (1) | GR3036508T3 (de) |
NO (1) | NO984482L (de) |
NZ (1) | NZ332011A (de) |
PT (1) | PT889891E (de) |
TW (1) | TW382016B (de) |
WO (1) | WO1997035857A1 (de) |
ZA (1) | ZA972776B (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750720A (en) * | 1996-03-28 | 1998-05-12 | Ortho Pharmaceutical Corporation | 4- (thien-3-yl)methyl!-imidazole analgesics |
US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
CA2312334A1 (en) * | 1997-12-04 | 1999-06-10 | Allergan Sales, Inc. | Substituted imidazole derivatives having agonist-like activity at alpha 2b or 2b/2c adrenergic receptors |
AU2002254265B2 (en) * | 1997-12-04 | 2008-05-15 | Allergan, Inc. | Imidiazole derivatives and their use as agonists selective at alpha 2B or 2B/2C adrenergic receptors |
US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
US6426356B1 (en) | 1998-11-18 | 2002-07-30 | Ortho-Mcneil Pharmaceutical, Inc. | Imidazoethyl thiophenes |
US6465486B1 (en) | 1999-03-12 | 2002-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl/quinolinyl imidazoles |
TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI894911A0 (fi) * | 1989-10-17 | 1989-10-17 | Farmos Oy | En terapeutiskt vaerdefull foerening. |
EP0573581A4 (en) * | 1991-02-26 | 1994-06-29 | Arc 1 Inc | Compositions and methods of treatment of sympathetically maintained pain |
-
1996
- 1996-03-28 US US08/625,447 patent/US5621113A/en not_active Expired - Lifetime
-
1997
- 1997-03-26 WO PCT/US1997/004768 patent/WO1997035857A1/en active IP Right Grant
- 1997-03-26 EP EP97916963A patent/EP0889891B1/de not_active Expired - Lifetime
- 1997-03-26 ES ES97916963T patent/ES2159857T3/es not_active Expired - Lifetime
- 1997-03-26 AT AT97916963T patent/ATE201869T1/de active
- 1997-03-26 NZ NZ332011A patent/NZ332011A/en not_active IP Right Cessation
- 1997-03-26 CA CA002250929A patent/CA2250929C/en not_active Expired - Lifetime
- 1997-03-26 DK DK97916963T patent/DK0889891T3/da active
- 1997-03-26 JP JP53454597A patent/JP4018145B2/ja not_active Expired - Lifetime
- 1997-03-26 PT PT97916963T patent/PT889891E/pt unknown
- 1997-03-26 AU AU25440/97A patent/AU718719B2/en not_active Expired
- 1997-03-26 DE DE69705114T patent/DE69705114T2/de not_active Expired - Lifetime
- 1997-04-01 ZA ZA972776A patent/ZA972776B/xx unknown
- 1997-04-28 TW TW086105509A patent/TW382016B/zh not_active IP Right Cessation
-
1998
- 1998-09-25 NO NO984482A patent/NO984482L/no unknown
-
2001
- 2001-08-31 GR GR20010401368T patent/GR3036508T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ332011A (en) | 2000-02-28 |
ES2159857T3 (es) | 2001-10-16 |
AU2544097A (en) | 1997-10-17 |
GR3036508T3 (en) | 2001-11-30 |
US5621113A (en) | 1997-04-15 |
AU718719B2 (en) | 2000-04-20 |
JP2000507548A (ja) | 2000-06-20 |
EP0889891A1 (de) | 1999-01-13 |
NO984482L (no) | 1998-11-24 |
JP4018145B2 (ja) | 2007-12-05 |
DE69705114D1 (de) | 2001-07-12 |
DK0889891T3 (da) | 2001-09-03 |
EP0889891B1 (de) | 2001-06-06 |
NO984482D0 (no) | 1998-09-25 |
PT889891E (pt) | 2001-09-28 |
ATE201869T1 (de) | 2001-06-15 |
CA2250929A1 (en) | 1997-10-02 |
TW382016B (en) | 2000-02-11 |
WO1997035857A1 (en) | 1997-10-02 |
ZA972776B (en) | 1998-10-01 |
CA2250929C (en) | 2005-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: ORTHO-MCNEIL PHARMACEUTICAL, INC., RARITAN, N.J., |
|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |