DE69704206D1 - Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln - Google Patents
Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermittelnInfo
- Publication number
- DE69704206D1 DE69704206D1 DE69704206T DE69704206T DE69704206D1 DE 69704206 D1 DE69704206 D1 DE 69704206D1 DE 69704206 T DE69704206 T DE 69704206T DE 69704206 T DE69704206 T DE 69704206T DE 69704206 D1 DE69704206 D1 DE 69704206D1
- Authority
- DE
- Germany
- Prior art keywords
- self
- expression
- tissue
- expression vectors
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title abstract 2
- 230000007774 longterm Effects 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16241—Use of virus, viral particle or viral elements as a vector
- C12N2710/16243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Magnetic Ceramics (AREA)
- Telephonic Communication Services (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9617214.3A GB9617214D0 (en) | 1996-08-16 | 1996-08-16 | Vector |
US2504096P | 1996-08-28 | 1996-08-28 | |
PCT/GB1997/002213 WO1998007876A2 (en) | 1996-08-16 | 1997-08-18 | Self-replicating episomal expression vectors conferring tissue-specific gene expression |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69704206D1 true DE69704206D1 (de) | 2001-04-12 |
DE69704206T2 DE69704206T2 (de) | 2001-08-30 |
Family
ID=26309883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69704206T Expired - Fee Related DE69704206T2 (de) | 1996-08-16 | 1997-08-18 | Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0918874B1 (de) |
JP (1) | JP2000516472A (de) |
AT (1) | ATE199570T1 (de) |
AU (1) | AU725474B2 (de) |
CA (1) | CA2263796A1 (de) |
DE (1) | DE69704206T2 (de) |
DK (1) | DK0918874T3 (de) |
ES (1) | ES2157084T3 (de) |
GR (1) | GR3035838T3 (de) |
PT (1) | PT918874E (de) |
WO (1) | WO1998007876A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999021979A1 (en) * | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Human papillomavirus vectors |
US6689606B2 (en) | 1998-07-21 | 2004-02-10 | M.L. Laboratories Plc | Polynucleotide |
KR100795626B1 (ko) | 1998-07-21 | 2008-01-17 | 코브라 바이오매뉴팩쳐링 피엘씨. | 도처에 있는 염색질 개방 요소(유씨오이)를 포함하는폴리뉴클레오티드 |
US6417002B1 (en) * | 1999-02-11 | 2002-07-09 | Pharmacopeia, Inc. | Method for maintenance and selection of episomes |
DE19942149A1 (de) * | 1999-09-03 | 2001-03-15 | Daniele Zink | Verfahren zur Expression von exogenen Sequenzen in Säugerzellen |
JP2004500097A (ja) | 2000-03-02 | 2004-01-08 | エムエル ラボラトリーズ ピーエルシー | Tcf応答性エレメント |
AU2001290067B2 (en) | 2000-09-20 | 2007-04-05 | Emd Millipore Corporation | Artificial ubiquitous chromatin opening elements (UCOE) |
US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
JP2005500019A (ja) | 2001-04-05 | 2005-01-06 | エムエル ラボラトリーズ ピーエルシー | 改良された遺伝子発現 |
JP5016779B2 (ja) * | 2001-05-03 | 2012-09-05 | フィット バイオテク オーワイ | 発現ベクターおよびその使用方法 |
FI116851B (fi) | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
GB2389115B (en) | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
CA2487206A1 (en) | 2002-10-07 | 2004-04-15 | Ludwig Institute Cancer Research | P53 binding polypeptide |
ES2345335T3 (es) | 2003-02-01 | 2010-09-21 | Millipore Corporation | Elementos geneticos mejorados que proporcionan altos niveles de expresion. |
FI116068B (fi) | 2003-09-15 | 2005-09-15 | Fit Biotech Oyj Plc | Uusi selektiojärjestelmä, siinä käyttökelpoinen vektori, bakteerisolukantoja sekä menetelmä solujen valikoimiseksi |
GB0328690D0 (en) | 2003-12-10 | 2004-01-14 | Ludwig Inst Cancer Res | Tumour suppressor protein |
GB0406330D0 (en) * | 2004-03-20 | 2004-04-21 | Univ Sheffield | Gene screen |
GB0509965D0 (en) | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
US8058027B2 (en) | 2007-01-08 | 2011-11-15 | Millipore Corporation | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants |
DK2571998T3 (en) * | 2010-05-19 | 2017-09-25 | Icosagen Cell Factory Oü | METHOD AND KIT FOR IDENTIFICATION OF CHEMICAL COMPOUNDS MADE TO INHIBIT HUMAN PAPILLOMA VIRUS REPLICATION |
JP5863338B2 (ja) | 2011-08-25 | 2016-02-16 | 株式会社東芝 | プラスミド型ベクター、遺伝子プロモーター活性の検出方法、及びアッセイキット |
WO2015160928A2 (en) | 2014-04-15 | 2015-10-22 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
WO2020112904A1 (en) | 2018-11-26 | 2020-06-04 | Massachusetts Institute Of Technology | Compositions and methods for immune tolerance |
WO2021074695A1 (en) | 2019-10-16 | 2021-04-22 | Avacta Life Sciences Limited | PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES. |
GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
WO2022043686A1 (en) | 2020-08-25 | 2022-03-03 | Thrombosis Research Institute | Vaccine |
GB2606693A (en) | 2021-04-08 | 2022-11-23 | Exosis Inc | Fusion protein |
WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
GB202107057D0 (en) | 2021-05-18 | 2021-06-30 | Univ York | Glycosylation method |
EP4412711A1 (de) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Serumhalbwertszeiterweiterte pd-l1-bindende polypeptide |
EP4413038A1 (de) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1-bindende affimere |
WO2023153876A1 (ko) | 2022-02-10 | 2023-08-17 | 주식회사 아피셀테라퓨틱스 | Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도 |
WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
GB9027917D0 (en) * | 1990-12-21 | 1991-02-13 | Ici Plc | Expression systems |
US5631162A (en) * | 1993-06-11 | 1997-05-20 | Massachusetts Institute Of Technology | Retroviral vectors for transducing β-globin gene and β-locus control region derivatives |
WO1995032299A1 (en) * | 1994-05-20 | 1995-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | An autonomous replication system for mammalian cells |
US6110666A (en) * | 1994-06-09 | 2000-08-29 | Medical Research Council | Locus control subregions conferring integration-site independent transgene expression abstract of the disclosure |
AU4594996A (en) * | 1994-11-30 | 1996-06-19 | Chiron Viagene, Inc. | Recombinant alphavirus vectors |
-
1997
- 1997-08-18 CA CA002263796A patent/CA2263796A1/en not_active Abandoned
- 1997-08-18 AT AT97937661T patent/ATE199570T1/de not_active IP Right Cessation
- 1997-08-18 DE DE69704206T patent/DE69704206T2/de not_active Expired - Fee Related
- 1997-08-18 PT PT97937661T patent/PT918874E/pt unknown
- 1997-08-18 JP JP10510501A patent/JP2000516472A/ja not_active Ceased
- 1997-08-18 AU AU40209/97A patent/AU725474B2/en not_active Ceased
- 1997-08-18 DK DK97937661T patent/DK0918874T3/da active
- 1997-08-18 WO PCT/GB1997/002213 patent/WO1998007876A2/en active IP Right Grant
- 1997-08-18 ES ES97937661T patent/ES2157084T3/es not_active Expired - Lifetime
- 1997-08-18 EP EP97937661A patent/EP0918874B1/de not_active Expired - Lifetime
-
2001
- 2001-05-08 GR GR20010400686T patent/GR3035838T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT918874E (pt) | 2001-08-30 |
WO1998007876A2 (en) | 1998-02-26 |
EP0918874B1 (de) | 2001-03-07 |
WO1998007876A3 (en) | 1998-04-16 |
AU4020997A (en) | 1998-03-06 |
JP2000516472A (ja) | 2000-12-12 |
DK0918874T3 (da) | 2001-05-14 |
CA2263796A1 (en) | 1998-02-26 |
EP0918874A2 (de) | 1999-06-02 |
ES2157084T3 (es) | 2001-08-01 |
AU725474B2 (en) | 2000-10-12 |
ATE199570T1 (de) | 2001-03-15 |
DE69704206T2 (de) | 2001-08-30 |
GR3035838T3 (en) | 2001-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69704206D1 (de) | Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln | |
EP1176195A4 (de) | VERFAHREN ZUR KONTROLLE DER AKTIVITäT VON IMMUNOLOGISCH FUNKTIONELLEM MOLEKüL | |
DK0939763T3 (da) | Styret skift-medieret DNA-rekombination | |
AU7826491A (en) | Novel bacillus thuringiensis microbes active against nematodes, and genes encoding novel nematode-active toxins cloned from bacillus thuringiensis isolates | |
PT805822E (pt) | Eritropoietina seca por pulverizacao | |
DE69434663D1 (de) | Nukleotid-sequenzen zur kontrolle der exprimierung von dns-sequenzen in einem zellulärem wirt | |
DE69736502D1 (de) | Verstärkungsregler | |
AU3938397A (en) | Artificial promoter libraries for selected organisms and promoters derived from such libraries | |
CY1108688T1 (el) | Μυκητοκτονα μειγματα στη βαση ενωσεων αμιδιου | |
AU2002230691A1 (en) | Putrescine-n-methyltransferase promoter | |
DE69818097D1 (de) | Rückkopplungdruck- regelsystem für gleitringdichtung | |
EP0826966A3 (de) | Methode zur Stabilisierung von Plättchen | |
EP0608696A3 (en) | Heterologous signal sequences for secretion of insect controlling proteins. | |
EP0654084A4 (de) | Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene. | |
EP1010761A4 (de) | Gen | |
AU689803B2 (en) | Plant-derived phospholipase D gene | |
AU1581397A (en) | Novel tumor suppressor gene, dpc4 | |
AU2744995A (en) | Expression control polynucleotides derived from spliceosomal protein gene promoters | |
ATE371032T1 (de) | Methoden und materialien fur genexpression | |
WO1998044099A3 (fr) | Methodes de detection d'interactions entre plusieurs proteines | |
AU1932497A (en) | Gene promoter sequence from banana | |
ATE125300T1 (de) | Kontrolle der anhäufung von abweichenden expressionsvektoren während der fermentationsverfahren. | |
DE69723940D1 (de) | Verstärkungsregler | |
WO2000003010A3 (en) | Protein secretion from bacteria having reduced expression of a product encoded by the dlt operon | |
AU690974B2 (en) | Polymorphs A and B of 1-(diphenylmethyl)-4- 3-(2-phenyl-1,3- dioxolan-2-yl)propyl piperazine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |