EP0654084A4 - Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene. - Google Patents

Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene.

Info

Publication number
EP0654084A4
EP0654084A4 EP93916670A EP93916670A EP0654084A4 EP 0654084 A4 EP0654084 A4 EP 0654084A4 EP 93916670 A EP93916670 A EP 93916670A EP 93916670 A EP93916670 A EP 93916670A EP 0654084 A4 EP0654084 A4 EP 0654084A4
Authority
EP
European Patent Office
Prior art keywords
reponsible
genes
molecular cloning
clostridium histolyticum
collagenase production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93916670A
Other languages
English (en)
French (fr)
Other versions
EP0654084A1 (de
Inventor
Hun-Chi Lin
Shau-Ping Lei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trigen Inc
Original Assignee
Trigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trigen Inc filed Critical Trigen Inc
Publication of EP0654084A1 publication Critical patent/EP0654084A1/de
Publication of EP0654084A4 publication Critical patent/EP0654084A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP93916670A 1992-06-22 1993-06-22 Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene. Withdrawn EP0654084A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90212992A 1992-06-22 1992-06-22
US902129 1992-06-22
PCT/US1993/005944 WO1994000580A1 (en) 1992-06-22 1993-06-22 Molecular cloning of the genes reponsible for collagenase production from clostridium histolyticum

Publications (2)

Publication Number Publication Date
EP0654084A1 EP0654084A1 (de) 1995-05-24
EP0654084A4 true EP0654084A4 (de) 1996-07-03

Family

ID=25415339

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93916670A Withdrawn EP0654084A4 (de) 1992-06-22 1993-06-22 Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene.

Country Status (5)

Country Link
EP (1) EP0654084A4 (de)
JP (1) JPH08500970A (de)
AU (1) AU4644793A (de)
CA (1) CA2138948A1 (de)
WO (1) WO1994000580A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005477A1 (en) * 1993-08-12 1995-02-23 University Of Maryland Thermostable alkaline metalloprotease produced by a hyphomonas, and preparation thereof
DE4408940A1 (de) * 1994-03-16 1995-10-05 Boehringer Mannheim Gmbh Rekombinante Collagenase Typ II aus Clostridium histolyticum und ihre Verwendung zur Isolierung von Zellen und Zellverbänden
EA000583B1 (ru) * 1995-03-16 1999-12-29 Кноль Аг СМЕСЬ ФЕРМЕНТОВ, ВЫДЕЛЕННЫХ ИЗ БАКТЕРИЙ Clostridium histolyticum
CA2193354A1 (en) * 1995-04-25 1996-10-31 Catherine Lee Composition containing collagenase and chymopapain for isolating hepatocytes and pancreatic islet cells
US5670358A (en) * 1995-10-19 1997-09-23 Baxter International Inc. Method for inhibiting chymopapain and papain enzyme activity with polysaccharides of animal origin
BR9713108A (pt) * 1996-11-19 2004-06-22 Roche Diagnostics Gmbh Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
US6280993B1 (en) * 1999-08-24 2001-08-28 Ichiro Yamato Gene encoding class I collagenase
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US20090191608A1 (en) * 2008-01-22 2009-07-30 Baylor Research Institute Pancreatic Islet Cell Preparation and Transplantation
IT1397646B1 (it) 2009-12-15 2013-01-18 Seidita Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
CN102174548B (zh) * 2011-03-01 2012-07-11 山东大学 一种深海适冷耐盐胶原蛋白酶及其编码基因myr02与应用
DK2802652T3 (da) * 2012-01-12 2019-07-15 Endo Global Ventures Clostridium histolyticum enzym
EP4591945A2 (de) 2017-03-01 2025-07-30 Endo Operations Limited Vorrichtung und verfahren zur beurteilung und behandlung von cellulite
AU2018244426B2 (en) 2017-03-28 2024-09-19 Endo Ventures Limited Improved method of producing collagenase
CN115058443B (zh) * 2022-06-22 2023-03-24 广州市乾相生物科技有限公司 转录抑制质粒pCRISPR-nadG及其在提高产溶剂梭菌胞内还原力中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014447A1 (en) * 1990-03-22 1991-10-03 Lin Hun Chi MOLECULAR CLONING OF THE GENES RESPONSIBLE FOR COLLAGENASE PRODUCTION FROM $i(CLOSTRIDIUM HISTOLYTICUM)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014447A1 (en) * 1990-03-22 1991-10-03 Lin Hun Chi MOLECULAR CLONING OF THE GENES RESPONSIBLE FOR COLLAGENASE PRODUCTION FROM $i(CLOSTRIDIUM HISTOLYTICUM)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9400580A1 *

Also Published As

Publication number Publication date
WO1994000580A1 (en) 1994-01-06
JPH08500970A (ja) 1996-02-06
CA2138948A1 (en) 1994-01-06
EP0654084A1 (de) 1995-05-24
AU4644793A (en) 1994-01-24

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19960517

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Effective date: 19970106