DE69637685D1 - Kommerzielle herstellung von aprotinin in pflanzen - Google Patents
Kommerzielle herstellung von aprotinin in pflanzenInfo
- Publication number
- DE69637685D1 DE69637685D1 DE69637685T DE69637685T DE69637685D1 DE 69637685 D1 DE69637685 D1 DE 69637685D1 DE 69637685 T DE69637685 T DE 69637685T DE 69637685 T DE69637685 T DE 69637685T DE 69637685 D1 DE69637685 D1 DE 69637685D1
- Authority
- DE
- Germany
- Prior art keywords
- aprotinin
- plants
- protein
- plant
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pest Control & Pesticides (AREA)
- Insects & Arthropods (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/554,161 US5824870A (en) | 1995-11-06 | 1995-11-06 | Commercial production of aprotinin in plants |
PCT/US1996/017089 WO1997017453A1 (en) | 1995-11-06 | 1996-10-31 | Commercial production of aprotinin in plants |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69637685D1 true DE69637685D1 (de) | 2008-10-30 |
Family
ID=24212272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637685T Expired - Lifetime DE69637685D1 (de) | 1995-11-06 | 1996-10-31 | Kommerzielle herstellung von aprotinin in pflanzen |
Country Status (7)
Country | Link |
---|---|
US (1) | US5824870A (de) |
EP (1) | EP0859852B1 (de) |
AT (1) | ATE408698T1 (de) |
AU (1) | AU1156797A (de) |
CA (1) | CA2233538C (de) |
DE (1) | DE69637685D1 (de) |
WO (1) | WO1997017453A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6504085B1 (en) | 1997-03-07 | 2003-01-07 | Prodigene, Inc. | Methods of commercial production and extraction of protein from seed |
US7071384B2 (en) | 1997-03-07 | 2006-07-04 | Genencor International, Inc. | Methods for commercial production of heterologous laccase in plant tissue and extraction of the laccase from plant seed |
WO1998039461A1 (en) * | 1997-03-20 | 1998-09-11 | Prodigene Inc. | Methods of commercial production and extraction of protein from seed |
AR020090A1 (es) * | 1998-06-15 | 2002-04-10 | John Innes Ct | Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion |
US6512162B2 (en) | 1998-07-10 | 2003-01-28 | Calgene Llc | Expression of eukaryotic peptides in plant plastids |
EP1097211B1 (de) | 1998-07-10 | 2007-04-18 | Calgene LLC | Expression eukarotischer peptide in pflanzenplastiden |
US6232527B1 (en) * | 1998-12-15 | 2001-05-15 | Pioneer Hi-Bred International, Inc. | Maize Rad2/FEN-1 orthologues and uses thereof |
US7390936B1 (en) | 1999-08-23 | 2008-06-24 | Sembiosys Genetics Inc. | Commercial production of chymosin in plants |
WO2001021270A2 (en) * | 1999-09-21 | 2001-03-29 | Prodigene, Inc. | Methods for producing recombinant proteins |
BR0209745A (pt) | 2001-05-30 | 2004-08-10 | Chromos Molecular Systems Inc | Cromossomas artificiais de plantas, usos e dos mesmos e método para preparação de cromossomas artificiais de plantas |
PT2311432E (pt) | 2002-06-07 | 2015-02-09 | Dyax Corp | Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
CA2490781A1 (en) | 2002-06-28 | 2004-01-08 | University Of Guelph | Harvest-inducible genes from alfalfa (medicago sativa) and methods of use thereof |
US7329798B2 (en) * | 2002-06-28 | 2008-02-12 | University Of Guelph | Harvest-inducible regulatory elements and methods of using same |
US20040106198A1 (en) * | 2002-07-16 | 2004-06-03 | Large Scale Biology Corporation | Inhibition of peptide cleavage in plants |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
WO2006042327A2 (en) * | 2004-10-12 | 2006-04-20 | Large Scale Biology Corporation | Plant-produced recombinant aprotinin and aprotinin variants |
US10150970B2 (en) | 2011-07-27 | 2018-12-11 | Applied Biotechnology Institute, Inc. | Methods to increase antigenicity of membrane-bound polypeptides produced in plants |
KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
US11090380B2 (en) | 2018-06-04 | 2021-08-17 | Applied Biotechnology Institute, Inc. | Methods and compositions to increase immune response to vaccines |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
US4914025A (en) * | 1985-12-05 | 1990-04-03 | Colin Manoil | Export of intra-cellular substances |
GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
ES2150410T3 (es) * | 1988-06-20 | 2000-12-01 | Novartis Ag | Procedimiento para el combate de parasitos de plantas. |
WO1990001551A1 (en) * | 1988-07-29 | 1990-02-22 | Washington University School Of Medicine | Producing commercially valuable polypeptides with genetically transformed endosperm tissue |
NL8901932A (nl) * | 1989-07-26 | 1991-02-18 | Mogen Int | Produktie van heterologe eiwitten in planten of plantecellen. |
US5258302A (en) * | 1990-07-03 | 1993-11-02 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA for expression of aprotinin in methylotrophic yeast cells |
CA2118113C (en) * | 1991-02-22 | 2002-01-08 | Maurice M. Moloney | Oil-body proteins as carriers of high-value peptides in plants |
WO1993020217A1 (en) * | 1992-03-31 | 1993-10-14 | Kanebo Limited | Plant virus vector, plasmid, method of expressing foreign gene, and method of acquiring foreign gene product |
US5460952A (en) * | 1992-11-04 | 1995-10-24 | National Science Counsil Of R.O.C. | Gene expression system comprising the promoter region of the α-amylase genes |
EP0680258A1 (de) * | 1993-01-25 | 1995-11-08 | Pioneer Hi-Bred International, Inc. | Aprotinin und synergistische kombinationen desselben mit lektinen als larvizide gegen insektenplagen landwirtschaftlicher pflanzen, erntematerial davon und produkte die aus diesem erntematerial erhalten werden |
US5693506A (en) * | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
-
1995
- 1995-11-06 US US08/554,161 patent/US5824870A/en not_active Expired - Lifetime
-
1996
- 1996-10-31 AT AT96942722T patent/ATE408698T1/de not_active IP Right Cessation
- 1996-10-31 CA CA2233538A patent/CA2233538C/en not_active Expired - Lifetime
- 1996-10-31 DE DE69637685T patent/DE69637685D1/de not_active Expired - Lifetime
- 1996-10-31 EP EP96942722A patent/EP0859852B1/de not_active Expired - Lifetime
- 1996-10-31 WO PCT/US1996/017089 patent/WO1997017453A1/en active Application Filing
- 1996-10-31 AU AU11567/97A patent/AU1156797A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2233538A1 (en) | 1997-05-15 |
ATE408698T1 (de) | 2008-10-15 |
EP0859852A1 (de) | 1998-08-26 |
CA2233538C (en) | 2010-05-25 |
AU1156797A (en) | 1997-05-29 |
EP0859852B1 (de) | 2008-09-17 |
WO1997017453A1 (en) | 1997-05-15 |
US5824870A (en) | 1998-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |