DE69637560D1 - Methode zur in vivo regulation der herzmuskelkontraktilität - Google Patents

Methode zur in vivo regulation der herzmuskelkontraktilität

Info

Publication number
DE69637560D1
DE69637560D1 DE69637560T DE69637560T DE69637560D1 DE 69637560 D1 DE69637560 D1 DE 69637560D1 DE 69637560 T DE69637560 T DE 69637560T DE 69637560 T DE69637560 T DE 69637560T DE 69637560 D1 DE69637560 D1 DE 69637560D1
Authority
DE
Germany
Prior art keywords
melk
contractility
heart
vivo regulation
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637560T
Other languages
English (en)
Inventor
Wolfgang H Dillmann
Frank Giordano
Rubin Mestril
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69637560D1 publication Critical patent/DE69637560D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69637560T 1995-04-11 1996-04-11 Methode zur in vivo regulation der herzmuskelkontraktilität Expired - Lifetime DE69637560D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/420,306 US6605274B1 (en) 1995-04-11 1995-04-11 Method for in vivo regulation of cardiac muscle contractility
PCT/US1996/005052 WO1996032139A1 (en) 1995-04-11 1996-04-11 Method for in vivo regulation of cardiac muscle contractility

Publications (1)

Publication Number Publication Date
DE69637560D1 true DE69637560D1 (de) 2008-07-24

Family

ID=23665931

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637560T Expired - Lifetime DE69637560D1 (de) 1995-04-11 1996-04-11 Methode zur in vivo regulation der herzmuskelkontraktilität

Country Status (8)

Country Link
US (1) US6605274B1 (de)
EP (3) EP1977767B1 (de)
AU (1) AU5482096A (de)
CA (1) CA2217967C (de)
DE (1) DE69637560D1 (de)
ES (1) ES2308776T3 (de)
HK (1) HK1121399A1 (de)
WO (1) WO1996032139A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745416B2 (en) * 1995-04-11 2010-06-29 The Regents Of The University Of California Method for in vivo regulation of cardiac muscle contractility
FR2753722A1 (fr) * 1996-09-26 1998-03-27 Smithkline Beecham Lab Procede de detection de modulateurs de relaxation cardiaque et modulateurs ainsi obtenus
US20020040010A1 (en) * 1997-07-22 2002-04-04 Anthony Rosenzweig Use of agents to treat heart disorders
US20090239940A1 (en) * 1997-07-22 2009-09-24 Del Monte Federica Treating heart failure and ventricular arrhythmias
US20040228834A1 (en) * 1998-03-09 2004-11-18 Jeffrey Isner Compositions and methods for modulating vascularization
US6676937B1 (en) * 1998-03-09 2004-01-13 Caritas St. Elizabeth's Medical Center Of Boston Inc. Compositions and methods for modulating vascularization
US20030149113A1 (en) 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
IL154769A0 (en) * 2000-09-06 2003-10-31 Univ Johns Hopkins Cardiac arrhythmia treatment methods
US20090175790A1 (en) * 2000-09-06 2009-07-09 The Johns Hopkins University Cardiac arrhythmia treatment methods and biological pacemaker
CA2445578C (en) * 2001-04-27 2012-08-28 Johns Hopkins University Biological pacemaker comprising dominant-negative kir2.1aaa
US6990222B2 (en) * 2001-11-21 2006-01-24 Arnold Ben A Calibration of tissue densities in computerized tomography
JP2006508073A (ja) * 2002-10-02 2006-03-09 ザ・ジョンズ・ホプキンス・ユニバーシティー 限局的カルシウムチャネル調節方法
US7291604B2 (en) * 2003-09-03 2007-11-06 The General Hospital Corporation Methods of treating restenosis
WO2007047522A2 (en) * 2005-10-14 2007-04-26 The Johns Hopkins University Biologically excitable cells
US8221738B2 (en) 2008-02-19 2012-07-17 Celladon Corporation Method for enhanced uptake of viral vectors in the myocardium
US20230078498A1 (en) * 2020-02-07 2023-03-16 University Of Rochester Targeted Translation of RNA with CRISPR-Cas13 to Enhance Protein Synthesis
CN114632147B (zh) * 2021-11-09 2024-04-30 南京大学 人类受试者心肌病的治疗

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699880A (en) 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
DE69034078T2 (de) 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5213961A (en) 1989-08-31 1993-05-25 Brigham And Women's Hospital Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction

Also Published As

Publication number Publication date
ES2308776T3 (es) 2008-12-01
EP1977767B1 (de) 2013-03-13
EP0820310A4 (de) 2003-05-28
CA2217967C (en) 2011-02-08
AU5482096A (en) 1996-10-30
US6605274B1 (en) 2003-08-12
WO1996032139A1 (en) 1996-10-17
EP1977767A1 (de) 2008-10-08
HK1121399A1 (en) 2009-04-24
EP0820310B1 (de) 2008-06-11
EP2305315A1 (de) 2011-04-06
CA2217967A1 (en) 1996-10-17
EP0820310A1 (de) 1998-01-28

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