DE69634671D1 - Mit Nima interagierende Proteine - Google Patents

Mit Nima interagierende Proteine

Info

Publication number
DE69634671D1
DE69634671D1 DE69634671T DE69634671T DE69634671D1 DE 69634671 D1 DE69634671 D1 DE 69634671D1 DE 69634671 T DE69634671 T DE 69634671T DE 69634671 T DE69634671 T DE 69634671T DE 69634671 D1 DE69634671 D1 DE 69634671D1
Authority
DE
Germany
Prior art keywords
interacting proteins
nima
nima interacting
proteins
interacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69634671T
Other languages
English (en)
Other versions
DE69634671T2 (de
Inventor
Tony Hunter
Ping Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of DE69634671D1 publication Critical patent/DE69634671D1/de
Application granted granted Critical
Publication of DE69634671T2 publication Critical patent/DE69634671T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69634671T 1995-11-13 1996-10-28 Mit Nima interagierende Proteine Expired - Fee Related DE69634671T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US555912 1995-11-13
US08/555,912 US5972697A (en) 1995-11-13 1995-11-13 NIMA interacting proteins
PCT/US1996/017334 WO1997017986A1 (en) 1995-11-13 1996-10-28 Nima interacting proteins

Publications (2)

Publication Number Publication Date
DE69634671D1 true DE69634671D1 (de) 2005-06-02
DE69634671T2 DE69634671T2 (de) 2006-03-02

Family

ID=24219099

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634671T Expired - Fee Related DE69634671T2 (de) 1995-11-13 1996-10-28 Mit Nima interagierende Proteine

Country Status (6)

Country Link
US (7) US5972697A (de)
EP (1) EP0880359B1 (de)
AU (1) AU1115897A (de)
CA (1) CA2235225C (de)
DE (1) DE69634671T2 (de)
WO (1) WO1997017986A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125677B2 (en) * 1995-11-13 2006-10-24 The Salk Institute For Biological Studies NIMA interacting proteins
US5972697A (en) * 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins
US6462173B1 (en) 1997-09-08 2002-10-08 Max-Planck-Gesellschaft Zur Forderung Der Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases
US20010016346A1 (en) * 1998-06-09 2001-08-23 Joseph P. Noel Pedtidyl-prolyl cis-trans isomerase inhibitors and uses therefore
US6495376B1 (en) * 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US20020025521A1 (en) * 1999-11-29 2002-02-28 Lu Kun Ping Pin1 as a marker for abnormal cell growth
DE60039453D1 (de) * 1999-11-29 2008-08-21 Beth Israel Hospital Pin1 als stadiumsmarker der aggressivität und/oder der metastasierung abnormale zellwachstum
EP1446044A4 (de) * 2001-02-09 2007-08-08 Pintex Pharmaceuticals Inc Pin1 als marker für prostatakrebs
EP1368630A4 (de) * 2001-02-09 2004-06-16 Pintex Pharmaceuticals Inc Pin1 als marker für abnormales zellwachstum
AU2003216501A1 (en) * 2002-03-01 2003-09-16 Pintex Pharmaceuticals, Inc. Methods of treating pin1 associated disorders
WO2003074001A2 (en) * 2002-03-01 2003-09-12 Pintex Pharmaceuticals, Inc. Methods for designing specific inhibitors for pin1 proline isomerase and pin1-related molecules
US8252520B2 (en) * 2002-10-11 2012-08-28 Taivex Therapeutics Corporation Methods and compounds for inhibiting Hec1 activity for the treatment of proliferative diseases
WO2004046329A2 (en) * 2002-11-14 2004-06-03 Pintex Pharmaceuticals, Inc. Levels of pin1 in normal and cancerous tissue
US20040176277A1 (en) * 2003-03-03 2004-09-09 Pintex Pharmaceuticals, Inc. Methods of treating Pin1 associated disorders
JP2007515937A (ja) * 2003-05-08 2007-06-21 ベス イスラエル デアコネス メディカル センター インコーポレイティッド ＮＦ−κＢの調節機構
US20050250742A1 (en) * 2004-03-03 2005-11-10 Pfizer Inc. Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1)
US20070027067A1 (en) * 2005-05-13 2007-02-01 Felicia Etzkorn Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof
US8771693B2 (en) 2009-10-27 2014-07-08 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
WO2012125724A1 (en) 2011-03-14 2012-09-20 Beth Israel Deaconess Medical Center Methods and compositions for the treatment of proliferative disorders
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US9439884B2 (en) 2011-05-26 2016-09-13 Beth Israel Deaconess Medical Center, Inc. Methods for the treatment of immune disorders
US9730941B2 (en) 2012-06-07 2017-08-15 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of Pin1
WO2016011268A1 (en) 2014-07-17 2016-01-21 Beth Israel Deaconess Medical Center, Inc. Atra for modulating pin1 activity and stability
US10351914B2 (en) 2014-07-17 2019-07-16 Beth Israel Deaconess Medical Center, Inc. Biomarkers for Pin1-associated disorders
US10548864B2 (en) 2015-03-12 2020-02-04 Beth Israel Deaconess Medical Center, Inc. Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
US7125677B2 (en) 1995-11-13 2006-10-24 The Salk Institute For Biological Studies NIMA interacting proteins
US5972697A (en) 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins
US6462173B1 (en) 1997-09-08 2002-10-08 Max-Planck-Gesellschaft Zur Forderung Der Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases
US6495376B1 (en) 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US20020025521A1 (en) 1999-11-29 2002-02-28 Lu Kun Ping Pin1 as a marker for abnormal cell growth
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US20020150898A1 (en) 2000-04-18 2002-10-17 Tang Y. Tom Novel nucleic acids and polypeptides
ES2616800T3 (es) * 2002-03-13 2017-06-14 Genomic Health, Inc. Obtención de perfil de expresión génica en tejidos tumorales biopsiados
BR0312555A (pt) * 2002-07-09 2007-06-19 Pfizer polipeptìdeos pin1 peptidil-prolil isomerase, suas estruturas cristalinas e a utilização destes para projeto de remédios

Also Published As

Publication number Publication date
US20050049404A1 (en) 2005-03-03
CA2235225A1 (en) 1997-05-22
US5952467A (en) 1999-09-14
US6596848B1 (en) 2003-07-22
AU1115897A (en) 1997-06-05
US20050027107A1 (en) 2005-02-03
US20050033032A1 (en) 2005-02-10
CA2235225C (en) 2008-08-26
EP0880359B1 (de) 2005-04-27
US7148003B2 (en) 2006-12-12
EP0880359A1 (de) 1998-12-02
DE69634671T2 (de) 2006-03-02
US7164012B2 (en) 2007-01-16
EP0880359A4 (de) 1999-09-29
WO1997017986A1 (en) 1997-05-22
US20070042467A1 (en) 2007-02-22
US7125955B2 (en) 2006-10-24
US5972697A (en) 1999-10-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee