BR0312555A - polipeptìdeos pin1 peptidil-prolil isomerase, suas estruturas cristalinas e a utilização destes para projeto de remédios - Google Patents
polipeptìdeos pin1 peptidil-prolil isomerase, suas estruturas cristalinas e a utilização destes para projeto de remédiosInfo
- Publication number
- BR0312555A BR0312555A BRPI0312555-6A BR0312555A BR0312555A BR 0312555 A BR0312555 A BR 0312555A BR 0312555 A BR0312555 A BR 0312555A BR 0312555 A BR0312555 A BR 0312555A
- Authority
- BR
- Brazil
- Prior art keywords
- pin1
- peptidyl prolyl
- prolyl isomerase
- polypeptides
- crystal structures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
POLIPEPTìDEOS PIN1 PEPTIDIL-PROLIL ISOMERASE, SUAS ESTRUTURAS CRISTALINAS E A UTILIZAçãO DESTES PARA PROJETO DE REMéDIOS São descritos polipeptídeos que têm o domínio PIN1 peptidil-prolil isomerase mas não têm o domínio WW de PIN1. São descritas também estruturas cristalinas desses polipeptídeos, incluindo a estrutura cristalina de um complexo PP1ase de PIN1-ligante. Os dados das coordenadas estruturais derivadas desses cristais fornecem uma descrição tridimensional do sítio de ligação ao substrato de isomerase PIN1 peptidil-prolil usado na descoberta de medicamento e projeto para a identificação e projeto de moduladores de atividade PIN1 peptidil-prolil isomerase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39488902P | 2002-07-09 | 2002-07-09 | |
PCT/IB2003/003101 WO2004005315A2 (en) | 2002-07-09 | 2003-06-27 | Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312555A true BR0312555A (pt) | 2007-06-19 |
Family
ID=30115784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312555-6A BR0312555A (pt) | 2002-07-09 | 2003-06-27 | polipeptìdeos pin1 peptidil-prolil isomerase, suas estruturas cristalinas e a utilização destes para projeto de remédios |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040171019A1 (pt) |
EP (1) | EP1521825A2 (pt) |
JP (1) | JP2005532061A (pt) |
AU (1) | AU2003281358A1 (pt) |
BR (1) | BR0312555A (pt) |
CA (1) | CA2491591A1 (pt) |
WO (1) | WO2004005315A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972697A (en) * | 1995-11-13 | 1999-10-26 | The Salk Institute For Biological Studies | NIMA interacting proteins |
US7125677B2 (en) * | 1995-11-13 | 2006-10-24 | The Salk Institute For Biological Studies | NIMA interacting proteins |
WO2004087720A1 (en) * | 2003-03-10 | 2004-10-14 | Pfizer Inc. | Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1) |
US20060074222A1 (en) * | 2004-07-15 | 2006-04-06 | Vernalis Plc | Determination of a phosphorylation site in PPIase domain of Pin1 and uses therefor |
WO2010096503A1 (en) * | 2009-02-17 | 2010-08-26 | Mcalister Technologies, Llc | Electrolytic cell and method of use thereof |
CA2605508A1 (en) * | 2005-05-12 | 2006-11-23 | Wisconsin Alumni Research Foundation | Blockade of pin1 prevents cytokine production by activated immune cells |
DK2432885T3 (da) * | 2009-05-18 | 2014-04-22 | Andrew C Saphire | Fremgangsmåde til forøgelse af retroviras smitsomhed |
US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
WO2012149334A2 (en) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
WO2017063755A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
WO2017063754A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds as pin1 modulators |
WO2017063757A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
CN110334416B (zh) * | 2019-06-18 | 2022-04-19 | 西北工业大学 | 双性能盘锻造时的预制坯优化设计方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010016346A1 (en) * | 1998-06-09 | 2001-08-23 | Joseph P. Noel | Pedtidyl-prolyl cis-trans isomerase inhibitors and uses therefore |
-
2003
- 2003-06-27 EP EP03740984A patent/EP1521825A2/en not_active Withdrawn
- 2003-06-27 CA CA002491591A patent/CA2491591A1/en not_active Abandoned
- 2003-06-27 BR BRPI0312555-6A patent/BR0312555A/pt unknown
- 2003-06-27 AU AU2003281358A patent/AU2003281358A1/en not_active Abandoned
- 2003-06-27 JP JP2004519118A patent/JP2005532061A/ja active Pending
- 2003-06-27 WO PCT/IB2003/003101 patent/WO2004005315A2/en active Search and Examination
- 2003-12-19 US US10/616,003 patent/US20040171019A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1521825A2 (en) | 2005-04-13 |
WO2004005315A3 (en) | 2004-07-01 |
CA2491591A1 (en) | 2004-01-15 |
WO2004005315A2 (en) | 2004-01-15 |
JP2005532061A (ja) | 2005-10-27 |
AU2003281358A8 (en) | 2004-01-23 |
US20040171019A1 (en) | 2004-09-02 |
AU2003281358A1 (en) | 2004-01-23 |
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