DE69630987T2 - Porphyrinmetallkomplex-Albumin-Einschlussverbindung und diese enthaltender Sauerstoff-Träger - Google Patents

Porphyrinmetallkomplex-Albumin-Einschlussverbindung und diese enthaltender Sauerstoff-Träger Download PDF

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Publication number
DE69630987T2
DE69630987T2 DE69630987T DE69630987T DE69630987T2 DE 69630987 T2 DE69630987 T2 DE 69630987T2 DE 69630987 T DE69630987 T DE 69630987T DE 69630987 T DE69630987 T DE 69630987T DE 69630987 T2 DE69630987 T2 DE 69630987T2
Authority
DE
Germany
Prior art keywords
metal complex
inclusion compound
carrier containing
oxygen carrier
porphyrin metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69630987T
Other languages
English (en)
Other versions
DE69630987D1 (de
Inventor
Eishun Tsuchida
Hiroyuki Nishide
Teruyuki Komatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TSUCHIDA, EISHUN, TOKYO, JP
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DE69630987D1 publication Critical patent/DE69630987D1/de
Publication of DE69630987T2 publication Critical patent/DE69630987T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Gas Separation By Absorption (AREA)
DE69630987T 1995-04-28 1996-04-26 Porphyrinmetallkomplex-Albumin-Einschlussverbindung und diese enthaltender Sauerstoff-Träger Expired - Fee Related DE69630987T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10631495A JP3428225B2 (ja) 1995-04-28 1995-04-28 ポルフィリン金属錯体−アルブミン包接化合物及び酸素運搬体

Publications (2)

Publication Number Publication Date
DE69630987D1 DE69630987D1 (de) 2004-01-22
DE69630987T2 true DE69630987T2 (de) 2004-10-21

Family

ID=14430526

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630987T Expired - Fee Related DE69630987T2 (de) 1995-04-28 1996-04-26 Porphyrinmetallkomplex-Albumin-Einschlussverbindung und diese enthaltender Sauerstoff-Träger

Country Status (6)

Country Link
US (1) US6008198A (de)
EP (1) EP0739634B1 (de)
JP (1) JP3428225B2 (de)
CA (1) CA2175115A1 (de)
DE (1) DE69630987T2 (de)
ES (1) ES2210326T3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3466516B2 (ja) 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
WO2002051403A1 (en) * 2000-12-21 2002-07-04 Resuscitek, Inc. Compositions of stable t3 and methods of use thereof
JP3816767B2 (ja) 2001-07-30 2006-08-30 独立行政法人科学技術振興機構 ポルフィリン金属錯体とそれを含有する酸素輸液
JP4529344B2 (ja) * 2002-06-03 2010-08-25 ニプロ株式会社 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤
JP3945428B2 (ja) * 2003-03-14 2007-07-18 ニプロ株式会社 ポルフィリン化合物、そのアルブミン包接化合物および人工酸素運搬体
EP1538151B1 (de) 2003-08-28 2006-10-18 Nipro Corporation Künstlicher Sauerstoffträger und Herstellungsverfahren dafür
JP2006008623A (ja) * 2004-06-28 2006-01-12 Hidetoshi Tsuchida スクシンイミジル基を持つポルフィリン化合物もしくはその金属錯体、ポルフィリン金属錯体結合アルブミンおよびそれを含有する酸素輸液
JP2006008622A (ja) * 2004-06-28 2006-01-12 Hidetoshi Tsuchida α３β置換構造のポルフィリン化合物もしくはその金属錯体、およびそれを含有する酸素輸液
JP2006045173A (ja) * 2004-08-09 2006-02-16 Hidetoshi Tsuchida 表面修飾血清アルブミン−金属ポルフィリン複合体、およびそれを含有する酸素輸液
EP1683529A1 (de) * 2005-01-25 2006-07-26 Nipro Corporation Einschlussverbindung von Porphyrinmetallkomplex in Albumin
EP1704870A1 (de) * 2005-03-25 2006-09-27 Nipro Corporation Verwendung von Eisenverbindungen als Radiosensitizer
WO2012117688A1 (ja) 2011-03-01 2012-09-07 学校法人中央大学 ヘモグロビン－アルブミン複合体、並びに該複合体を含む人工血漿増量剤及び人工酸素運搬体
CN112263679B (zh) * 2020-10-26 2023-11-21 深圳先进技术研究院 一种靶向载氧纳米声敏剂及其制备方法
WO2023201107A1 (en) * 2022-04-15 2023-10-19 Ohio State Innovation Foundation Colloidally stable heme-albumin complexes and methods of making and using thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925767B2 (ja) * 1981-06-10 1984-06-21 森六株式会社 鉄（２）ポルフィリン錯体を包接したリン脂質リポリ−ムおよび酸素吸脱着剤
JPS59162924A (ja) * 1983-03-09 1984-09-13 Hidetoshi Tsuchida 酸素吸脱着剤
AU663106B2 (en) * 1991-08-02 1995-09-28 Meiji Milk Products Co., Ltd. Porphyrin-based anti-HIV drug
JP3405741B2 (ja) * 1992-03-17 2003-05-12 財団法人生産開発科学研究所 近位塩基を持つポルフィリン金属錯体
JP3312953B2 (ja) * 1993-03-22 2002-08-12 財団法人生産開発科学研究所 ２位置側鎖を有するテトラフェニルポルフィリン金属錯体及びその製造法
WO1996003426A1 (en) * 1994-07-22 1996-02-08 Duke University Human serum albumin-porphyrin complexes with the ability to bind oxygen and therapeutic uses thereof

Also Published As

Publication number Publication date
EP0739634B1 (de) 2003-12-10
EP0739634A3 (de) 1999-03-31
ES2210326T3 (es) 2004-07-01
EP0739634A2 (de) 1996-10-30
US6008198A (en) 1999-12-28
JP3428225B2 (ja) 2003-07-22
JPH08301873A (ja) 1996-11-19
CA2175115A1 (en) 1996-10-29
DE69630987D1 (de) 2004-01-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TSUCHIDA, EISHUN, TOKYO, JP

8339 Ceased/non-payment of the annual fee