DE69624919T2 - Verfahren zur exprimierung und ausscheidung von löslichen extrazellularen domänen von humanem gonadotropinhormon rezeptoren - Google Patents

Verfahren zur exprimierung und ausscheidung von löslichen extrazellularen domänen von humanem gonadotropinhormon rezeptoren

Info

Publication number
DE69624919T2
DE69624919T2 DE69624919T DE69624919T DE69624919T2 DE 69624919 T2 DE69624919 T2 DE 69624919T2 DE 69624919 T DE69624919 T DE 69624919T DE 69624919 T DE69624919 T DE 69624919T DE 69624919 T2 DE69624919 T2 DE 69624919T2
Authority
DE
Germany
Prior art keywords
gonadotropinhormone
receptors
expressing
human
extracellular domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624919T
Other languages
English (en)
Other versions
DE69624919D1 (de
Inventor
P Sisk
Vui Cheng
Rogers Buckler
Lynn Prentice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of DE69624919D1 publication Critical patent/DE69624919D1/de
Application granted granted Critical
Publication of DE69624919T2 publication Critical patent/DE69624919T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69624919T 1995-06-02 1996-06-03 Verfahren zur exprimierung und ausscheidung von löslichen extrazellularen domänen von humanem gonadotropinhormon rezeptoren Expired - Fee Related DE69624919T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/460,576 US6033903A (en) 1995-06-02 1995-06-02 Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
PCT/IB1996/000709 WO1996038575A1 (en) 1995-06-02 1996-06-03 A method of expressing and secreting soluble extracellular domains of humain gonadotropin hormone receptors

Publications (2)

Publication Number Publication Date
DE69624919D1 DE69624919D1 (de) 2003-01-02
DE69624919T2 true DE69624919T2 (de) 2003-09-04

Family

ID=23829269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624919T Expired - Fee Related DE69624919T2 (de) 1995-06-02 1996-06-03 Verfahren zur exprimierung und ausscheidung von löslichen extrazellularen domänen von humanem gonadotropinhormon rezeptoren

Country Status (12)

Country Link
US (1) US6033903A (de)
EP (1) EP0832268B1 (de)
JP (1) JPH11505410A (de)
AT (1) ATE228169T1 (de)
AU (1) AU714030B2 (de)
CA (1) CA2222526A1 (de)
DE (1) DE69624919T2 (de)
DK (1) DK0832268T3 (de)
ES (1) ES2187658T3 (de)
IL (1) IL122178A (de)
PT (1) PT832268E (de)
WO (1) WO1996038575A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0894141T1 (en) 1996-02-20 2005-10-31 Applied Research Systems Ars Holding N.V. Hybrid proteins which form heterodimers
US5925549A (en) * 1996-04-15 1999-07-20 The Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain G-protein-coupled receptor compositions and methods
FR2761994B1 (fr) 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
NZ516258A (en) * 1999-06-07 2004-02-27 Immunex Corp Tek antagonists
GB9919409D0 (en) * 1999-08-18 1999-10-20 Univ Oxford Brookes Baculovirus expression system
US7879621B2 (en) * 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
WO2009137242A2 (en) * 2008-04-14 2009-11-12 Michigan State University Trichoplusia ni cell line and methods of use
EP3244907B1 (de) * 2015-01-13 2020-02-19 City of Hope Peptid-linkermasken mit ctla4-bindenden proteinen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005783A1 (en) * 1988-11-18 1990-05-31 Cetus Corporation Insect signal peptide mediated secretion of recombinant proteins
DE69033990T2 (de) * 1989-05-05 2003-02-13 Genentech Inc Glykoprotein-Hormonrezeptor-Moleküle
US5023328A (en) * 1989-08-04 1991-06-11 The Texas A&M University System Lepidopteran AKH signal sequence
US5155037A (en) * 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5516657A (en) * 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins

Also Published As

Publication number Publication date
DK0832268T3 (da) 2003-03-17
AU714030B2 (en) 1999-12-16
ES2187658T3 (es) 2003-06-16
US6033903A (en) 2000-03-07
AU6239196A (en) 1996-12-18
DE69624919D1 (de) 2003-01-02
EP0832268B1 (de) 2002-11-20
EP0832268A1 (de) 1998-04-01
ATE228169T1 (de) 2002-12-15
WO1996038575A1 (en) 1996-12-05
IL122178A (en) 2005-06-19
PT832268E (pt) 2003-04-30
JPH11505410A (ja) 1999-05-21
CA2222526A1 (en) 1996-12-05
IL122178A0 (en) 1998-04-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH

8339 Ceased/non-payment of the annual fee