DE69611842T2 - Optisch aktive substituierte phenylalkylamin-derivate - Google Patents
Optisch aktive substituierte phenylalkylamin-derivateInfo
- Publication number
- DE69611842T2 DE69611842T2 DE69611842T DE69611842T DE69611842T2 DE 69611842 T2 DE69611842 T2 DE 69611842T2 DE 69611842 T DE69611842 T DE 69611842T DE 69611842 T DE69611842 T DE 69611842T DE 69611842 T2 DE69611842 T2 DE 69611842T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- disease
- compound
- optically active
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940085239 selective calcium channel blockers with direct cardiac effects phenylalkylamine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010061296 Motor dysfunction Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 102100028656 Sigma non-opioid intracellular receptor 1 Human genes 0.000 abstract 1
- 101710104750 Sigma non-opioid intracellular receptor 1 Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14718095 | 1995-06-14 | ||
| PCT/JP1996/001613 WO1997000238A1 (fr) | 1995-06-14 | 1996-06-13 | Derives de phenylalkylamine substitues optiquement actifs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69611842D1 DE69611842D1 (de) | 2001-03-29 |
| DE69611842T2 true DE69611842T2 (de) | 2001-06-07 |
Family
ID=15424396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69611842T Expired - Fee Related DE69611842T2 (de) | 1995-06-14 | 1996-06-13 | Optisch aktive substituierte phenylalkylamin-derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5990151A (de) |
| EP (1) | EP0870758B1 (de) |
| KR (1) | KR19990022916A (de) |
| AT (1) | ATE199244T1 (de) |
| AU (1) | AU696458B2 (de) |
| CA (1) | CA2224580A1 (de) |
| DE (1) | DE69611842T2 (de) |
| DK (1) | DK0870758T3 (de) |
| ES (1) | ES2154821T3 (de) |
| WO (1) | WO1997000238A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101262867A (zh) * | 2005-07-01 | 2008-09-10 | 叶林发现公司 | 用于治疗肥胖的mao-b抑制剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329367A (en) * | 1974-08-05 | 1982-05-11 | Ciba-Geigy Corporation | 1-(Aralkoxyphenyl)-2-(bis-arylalkylamino)-alkanes |
| FR2626877B1 (fr) * | 1988-02-05 | 1991-04-05 | Delalande Sa | Ethers alkyliques ou benzyliques du phenol, leurs procedes de preparation et leur application en therapeutique |
| FR2645019A1 (de) * | 1989-03-30 | 1990-10-05 | Fournier Innovation Synergie | |
| EP0418430A1 (de) * | 1989-09-22 | 1991-03-27 | Duphar International Research B.V | Phenylalkylamin-Derivate mit anti-ischämischer Wirkung |
| WO1993007113A1 (en) * | 1991-10-04 | 1993-04-15 | Taisho Pharmaceutical Co., Ltd. | Alkoxyphenylalkylamine derivative |
| JPH0859578A (ja) * | 1994-06-17 | 1996-03-05 | Taisho Pharmaceut Co Ltd | 置換フェニルアルキルアミン誘導体 |
-
1996
- 1996-06-13 EP EP96917670A patent/EP0870758B1/de not_active Expired - Lifetime
- 1996-06-13 DK DK96917670T patent/DK0870758T3/da active
- 1996-06-13 US US08/981,539 patent/US5990151A/en not_active Expired - Fee Related
- 1996-06-13 AT AT96917670T patent/ATE199244T1/de not_active IP Right Cessation
- 1996-06-13 KR KR1019970709385A patent/KR19990022916A/ko not_active Application Discontinuation
- 1996-06-13 DE DE69611842T patent/DE69611842T2/de not_active Expired - Fee Related
- 1996-06-13 ES ES96917670T patent/ES2154821T3/es not_active Expired - Lifetime
- 1996-06-13 CA CA002224580A patent/CA2224580A1/en not_active Abandoned
- 1996-06-13 WO PCT/JP1996/001613 patent/WO1997000238A1/ja not_active Application Discontinuation
- 1996-06-13 AU AU60159/96A patent/AU696458B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU696458B2 (en) | 1998-09-10 |
| US5990151A (en) | 1999-11-23 |
| ES2154821T3 (es) | 2001-04-16 |
| EP0870758A1 (de) | 1998-10-14 |
| DE69611842D1 (de) | 2001-03-29 |
| AU6015996A (en) | 1997-01-15 |
| WO1997000238A1 (fr) | 1997-01-03 |
| EP0870758B1 (de) | 2001-02-21 |
| KR19990022916A (ko) | 1999-03-25 |
| EP0870758A4 (de) | 1998-10-14 |
| CA2224580A1 (en) | 1997-01-03 |
| DK0870758T3 (da) | 2001-06-18 |
| ATE199244T1 (de) | 2001-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |