DE69533000T2 - 3-hydroxy-2(1h)-pyridone als chelatbildner - Google Patents

3-hydroxy-2(1h)-pyridone als chelatbildner Download PDF

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Publication number
DE69533000T2
DE69533000T2 DE69533000T DE69533000T DE69533000T2 DE 69533000 T2 DE69533000 T2 DE 69533000T2 DE 69533000 T DE69533000 T DE 69533000T DE 69533000 T DE69533000 T DE 69533000T DE 69533000 T2 DE69533000 T2 DE 69533000T2
Authority
DE
Germany
Prior art keywords
hydroxy
hopo
chelating agents
pyridinone
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69533000T
Other languages
English (en)
Other versions
DE69533000D1 (de
Inventor
Kenneth Raymond
Jide Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley filed Critical University of California
Publication of DE69533000D1 publication Critical patent/DE69533000D1/de
Application granted granted Critical
Publication of DE69533000T2 publication Critical patent/DE69533000T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE69533000T 1995-06-14 1995-06-14 3-hydroxy-2(1h)-pyridone als chelatbildner Expired - Fee Related DE69533000T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1995/007766 WO1997000245A1 (en) 1995-06-14 1995-06-14 3-hydroxy-2(1h)-pyridinone chelating agents

Publications (2)

Publication Number Publication Date
DE69533000D1 DE69533000D1 (de) 2004-06-09
DE69533000T2 true DE69533000T2 (de) 2005-04-21

Family

ID=22249334

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533000T Expired - Fee Related DE69533000T2 (de) 1995-06-14 1995-06-14 3-hydroxy-2(1h)-pyridone als chelatbildner

Country Status (7)

Country Link
EP (1) EP0840727B1 (de)
AT (1) ATE266006T1 (de)
AU (1) AU2865995A (de)
DE (1) DE69533000T2 (de)
DK (1) DK0840727T3 (de)
ES (1) ES2221929T3 (de)
WO (1) WO1997000245A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
FI112796B (fi) * 2000-04-14 2004-01-15 Valtion Teknillinen Menetelmä oligo-/polymeripihkahappoaimididendrimeerien valmistamiseksi ja niiden käyttö
US6846915B2 (en) * 2001-08-13 2005-01-25 The Regents Of The University Of California Hydroxypyridonate and hydroxypyrimidinone chelating agents
EP1608352B1 (de) 2003-04-02 2009-12-30 Taigen Biotechnology Polyamin-verbindungen zur behandlung von chemokin-rezeptor-vermittelten krankheiten
US7504422B2 (en) 2003-04-02 2009-03-17 Taigen Biotechnology Co. Ltd. Polyamine compounds
DE102004062250A1 (de) * 2004-12-23 2006-07-06 Schering Ag Konjugate von Hydroxypyridinonderivat-Metallkomplexen mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR-Diagnostik
US7501526B2 (en) 2005-01-20 2009-03-10 Taigen Biotechnology Synthesis of polyamine compounds
AU2007272604B2 (en) 2006-07-10 2013-08-01 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
EP2104662A2 (de) * 2007-01-11 2009-09-30 GE Healthcare AS Chelatbildende mittel
US8475768B2 (en) 2007-08-13 2013-07-02 Ge Healthcare As Paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (MRI)
EP2178862A1 (de) * 2007-08-13 2010-04-28 GE Healthcare AS Chelatbildner, paramagnetische chelate daraus und ihre verwendung als kontrastmittel in der magnetresonanzbildgebung (mri)
EP2816038B8 (de) 2009-08-24 2019-12-25 Lumiphore, Inc. Hopo-chelatoren
GB201002508D0 (en) * 2010-02-12 2010-03-31 Algeta As Product
GB201019118D0 (en) 2010-11-11 2010-12-29 King S College Conjugates and their uses in molecular imaging
CN102603964B (zh) * 2012-01-15 2014-03-05 浙江工商大学 水溶性聚合物铁螯合剂及其制备方法和用途
US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8325494D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
US4698431A (en) * 1985-11-12 1987-10-06 The United States Of America As Represented By The United States Department Of Energy Hydroxypyridonate chelating agents

Also Published As

Publication number Publication date
AU2865995A (en) 1997-01-15
DE69533000D1 (de) 2004-06-09
WO1997000245A1 (en) 1997-01-03
ES2221929T3 (es) 2005-01-16
EP0840727A1 (de) 1998-05-13
ATE266006T1 (de) 2004-05-15
EP0840727B1 (de) 2004-05-06
DK0840727T3 (da) 2004-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee