DE69530975D1 - Rekombinante humanisierte antikörper gegen lewis y - Google Patents

Rekombinante humanisierte antikörper gegen lewis y

Info

Publication number
DE69530975D1
DE69530975D1 DE69530975T DE69530975T DE69530975D1 DE 69530975 D1 DE69530975 D1 DE 69530975D1 DE 69530975 T DE69530975 T DE 69530975T DE 69530975 T DE69530975 T DE 69530975T DE 69530975 D1 DE69530975 D1 DE 69530975D1
Authority
DE
Germany
Prior art keywords
lewis
humanized
specific antibodies
antibodies
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69530975T
Other languages
English (en)
Other versions
DE69530975T2 (de
Inventor
Francis J Carr
Lloyd J Old
Elisabeth Stockert
Sydney Welt
Kunio Kitamura
Pilar Garin-Chesa
Dr Kathryn Armour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center filed Critical Sloan Kettering Institute for Cancer Research
Publication of DE69530975D1 publication Critical patent/DE69530975D1/de
Application granted granted Critical
Publication of DE69530975T2 publication Critical patent/DE69530975T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69530975T 1994-03-08 1995-03-08 Rekombinante humanisierte antikörper gegen lewis y Expired - Lifetime DE69530975T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US207861 1994-03-08
US08/207,861 US6310185B1 (en) 1994-03-08 1994-03-08 Recombinant human anti-Lewis Y antibodies
PCT/US1995/003096 WO1995024484A1 (en) 1994-03-08 1995-03-08 Recombinant humanized anti-lewis y antibodies

Publications (2)

Publication Number Publication Date
DE69530975D1 true DE69530975D1 (de) 2003-07-10
DE69530975T2 DE69530975T2 (de) 2004-05-19

Family

ID=22772277

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530975T Expired - Lifetime DE69530975T2 (de) 1994-03-08 1995-03-08 Rekombinante humanisierte antikörper gegen lewis y

Country Status (10)

Country Link
US (3) US6310185B1 (de)
EP (1) EP0749482B1 (de)
AT (1) ATE242326T1 (de)
AU (1) AU696286B2 (de)
CA (1) CA2185114C (de)
DE (1) DE69530975T2 (de)
DK (1) DK0749482T3 (de)
ES (1) ES2199985T3 (de)
PT (1) PT749482E (de)
WO (1) WO1995024484A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US6663504B2 (en) 1999-11-01 2003-12-16 Callaway Golf Company Multiple material golf club head
US7128661B2 (en) * 1999-11-01 2006-10-31 Callaway Golf Company Multiple material golf club head
US6582323B2 (en) 1999-11-01 2003-06-24 Callaway Golf Company Multiple material golf club head
US6565452B2 (en) 1999-11-01 2003-05-20 Callaway Golf Company Multiple material golf club head with face insert
TW577761B (en) * 1999-11-01 2004-03-01 Callaway Golf Co Multiple material golf club head
US7125344B2 (en) * 1999-11-01 2006-10-24 Callaway Golf Company Multiple material golf club head
US6739983B2 (en) * 1999-11-01 2004-05-25 Callaway Golf Company Golf club head with customizable center of gravity
US7118493B2 (en) * 1999-11-01 2006-10-10 Callaway Golf Company Multiple material golf club head
US6491592B2 (en) 1999-11-01 2002-12-10 Callaway Golf Company Multiple material golf club head
HUP0303246A2 (hu) * 2001-02-23 2003-12-29 Immunex Corporation Aktív fehérjék fokozott kinyerése
PL224001B1 (pl) 2002-05-02 2016-11-30 Wyeth Corp Sposób wytwarzania stabilnej liofilizowanej kompozycji obejmującej monomeryczne koniugaty pochodna kalicheamycyny/przeciwciało anty-CD22, kompozycja otrzymana tym sposobem oraz jej zastosowanie
JP2005535723A (ja) 2002-08-20 2005-11-24 バイオティ セラピィーズ コープ 腫瘍特異的オリゴ糖エピトープおよびその用途
US6984181B2 (en) * 2002-09-25 2006-01-10 Callaway Golf Company Multiple material golf putter head
JP4206915B2 (ja) * 2002-12-27 2009-01-14 三菱マテリアル株式会社 パワーモジュール用基板
US20060011388A1 (en) * 2003-01-31 2006-01-19 Mohammed Boudrare Drill bit and cutter element having multiple extensions
US6883624B2 (en) * 2003-01-31 2005-04-26 Smith International, Inc. Multi-lobed cutter element for drill bit
US6929079B2 (en) * 2003-02-21 2005-08-16 Smith International, Inc. Drill bit cutter element having multiple cusps
CA2535804A1 (en) * 2003-08-14 2005-03-03 Wyeth Anti-lewis y anti-idiotypic antibodies and uses thereof
TW200539855A (en) * 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
RU2451082C2 (ru) * 2004-08-27 2012-05-20 Вайет Рисёрч Айрлэнд Лимитед Производство полипептидов
US7335491B2 (en) * 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US7300773B2 (en) * 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
US7549935B2 (en) * 2005-01-03 2009-06-23 Callaway Golf Company Golf club head
US7166038B2 (en) * 2005-01-03 2007-01-23 Callaway Golf Company Golf club head
US7163468B2 (en) 2005-01-03 2007-01-16 Callaway Golf Company Golf club head
US7311613B2 (en) * 2005-01-03 2007-12-25 Callaway Golf Company Golf club head
US7169060B2 (en) 2005-01-03 2007-01-30 Callaway Golf Company Golf club head
US7591737B2 (en) * 2005-01-03 2009-09-22 Callaway Golf Company Golf club head
US7559851B2 (en) * 2005-01-03 2009-07-14 Callaway Golf Company Golf club with high moment of inertia
US7488261B2 (en) * 2005-01-03 2009-02-10 Callaway Golf Company Golf club with high moment of inertia
US7568982B2 (en) 2005-01-03 2009-08-04 Callaway Golf Company Golf club with high moment of inertia
US20080206239A1 (en) 2005-02-03 2008-08-28 Antitope Limited Human Antibodies And Proteins
GB2427633B (en) * 2005-05-17 2007-08-15 Smith International Drill bit and method of designing a drill bit
US7757789B2 (en) * 2005-06-21 2010-07-20 Smith International, Inc. Drill bit and insert having bladed interface between substrate and coating
FI20055417A0 (fi) 2005-07-20 2005-07-20 Glykos Finland Oy Syöpäpesifiset glykaanit ja niiden käyttö
US9862770B2 (en) 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
US8883162B2 (en) 2005-10-19 2014-11-11 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
US20100226884A1 (en) * 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
WO2007067602A1 (en) * 2005-12-06 2007-06-14 Wyeth Interleukin-11 compositions and methods of use
PL1994055T3 (pl) 2006-03-10 2015-02-27 Wyeth Llc Przeciwciała anty-5T4 i ich zastosowanie
WO2007120626A2 (en) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of ankylosing spondylitis
US20100021451A1 (en) * 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
US7743855B2 (en) * 2006-09-05 2010-06-29 Smith International, Inc. Drill bit with cutter element having multifaceted, slanted top cutting surface
US7798258B2 (en) * 2007-01-03 2010-09-21 Smith International, Inc. Drill bit with cutter element having crossing chisel crests
US7631709B2 (en) 2007-01-03 2009-12-15 Smith International, Inc. Drill bit and cutter element having chisel crest with protruding pilot portion
US7686106B2 (en) * 2007-01-03 2010-03-30 Smith International, Inc. Rock bit and inserts with wear relief grooves
US8205692B2 (en) * 2007-01-03 2012-06-26 Smith International, Inc. Rock bit and inserts with a chisel crest having a broadened region
US7819754B2 (en) * 2007-09-13 2010-10-26 Callaway Golf Company Golf club with removable components
US7753809B2 (en) * 2007-12-19 2010-07-13 Cackett Matthew T Driver with deep AFT cavity
US8414422B2 (en) * 2009-12-16 2013-04-09 Callaway Golf Company External weight for golf club head
AU2010343304B2 (en) * 2010-01-19 2013-06-20 Immunomedics, Inc. Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type I receptor (IGF-1R)
CA2807607A1 (en) 2010-08-20 2012-02-23 Wyeth Llc Cell culture of growth factor-free adapted cells
US8607899B2 (en) 2011-02-18 2013-12-17 National Oilwell Varco, L.P. Rock bit and cutter teeth geometries
LT2837680T (lt) 2011-07-01 2020-07-10 Amgen Inc. Žinduolių ląstelių kultūra
SG11201401220SA (en) 2011-10-21 2014-07-30 Pfizer Addition of iron to improve cell culture
GB201910899D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Binding members
CN113214402B (zh) * 2021-06-03 2022-06-07 上海交通大学 分离的抗原结合蛋白及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5242824A (en) * 1988-12-22 1993-09-07 Oncogen Monoclonal antibody to human carcinomas
IL94872A (en) * 1989-06-30 1995-03-30 Oncogen Monoclonal or chimeric antibodies that react with human carcinoma, recombinant proteins that contain their anti-binding site, pharmaceutical preparations and kits that contain the
GB9019812D0 (en) * 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
EP0528767B1 (de) * 1991-08-21 2000-01-12 Novartis AG Antikörperderivate
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies

Also Published As

Publication number Publication date
WO1995024484A1 (en) 1995-09-14
EP0749482A1 (de) 1996-12-27
ES2199985T3 (es) 2004-03-01
CA2185114A1 (en) 1995-09-14
PT749482E (pt) 2003-10-31
AU696286B2 (en) 1998-09-03
US5874060A (en) 1999-02-23
AU1990795A (en) 1995-09-25
US6518415B1 (en) 2003-02-11
EP0749482B1 (de) 2003-06-04
US6310185B1 (en) 2001-10-30
DK0749482T3 (da) 2003-09-29
DE69530975T2 (de) 2004-05-19
CA2185114C (en) 2008-01-22
ATE242326T1 (de) 2003-06-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition