DE69522695D1 - Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes - Google Patents

Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes

Info

Publication number
DE69522695D1
DE69522695D1 DE69522695T DE69522695T DE69522695D1 DE 69522695 D1 DE69522695 D1 DE 69522695D1 DE 69522695 T DE69522695 T DE 69522695T DE 69522695 T DE69522695 T DE 69522695T DE 69522695 D1 DE69522695 D1 DE 69522695D1
Authority
DE
Germany
Prior art keywords
cyclosporin
pct
fusant
mutants
dependent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69522695T
Other languages
English (en)
Inventor
Jung Woo Kim
Kwang Moo Lee
Byoung Tack Choi
Jin Man Lee
Nak Kyu Sung
Kyeong Bok Min
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chong Kun Dang Corp
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Application granted granted Critical
Publication of DE69522695D1 publication Critical patent/DE69522695D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69522695T 1994-10-18 1995-10-16 Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes Expired - Lifetime DE69522695D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019940026689A KR0126610B1 (ko) 1994-10-18 1994-10-18 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
PCT/KR1995/000131 WO1996012032A1 (en) 1994-10-18 1995-10-16 Process for manufacturing cyclosporin a by highly productive fusant strain

Publications (1)

Publication Number Publication Date
DE69522695D1 true DE69522695D1 (de) 2001-10-18

Family

ID=19395381

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69522695T Expired - Lifetime DE69522695D1 (de) 1994-10-18 1995-10-16 Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes

Country Status (9)

Country Link
US (1) US5856141A (de)
EP (1) EP0781348B1 (de)
JP (1) JP2983638B2 (de)
KR (1) KR0126610B1 (de)
AT (1) ATE205539T1 (de)
AU (1) AU3674395A (de)
CA (1) CA2202037C (de)
DE (1) DE69522695D1 (de)
WO (1) WO1996012032A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
AU769429C (en) 1998-12-30 2004-10-28 Dexcel Limited Dispersible concentrate for the delivery of cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
ATE306558T1 (de) 2000-02-29 2005-10-15 Biocon Ltd Herstellung und reinigung von cyclosporin-a
ATE355359T1 (de) * 2001-03-22 2006-03-15 Gakkou Houjin Kitasato Gakuen Selektionsmedia für beauveriolid i oder iii und verfahren zur selektiven herstellung dieser substanzen
US7226906B2 (en) * 2004-08-16 2007-06-05 Array Biopharma, Inc. Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943529A (en) * 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
ES2078374T3 (es) * 1991-04-06 1995-12-16 Dresden Arzneimittel Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina.
US5244790A (en) * 1991-12-17 1993-09-14 Kim Jong K Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents

Also Published As

Publication number Publication date
JPH10500580A (ja) 1998-01-20
JP2983638B2 (ja) 1999-11-29
CA2202037A1 (en) 1996-04-25
EP0781348B1 (de) 2001-09-12
CA2202037C (en) 1999-03-30
EP0781348A1 (de) 1997-07-02
KR0126610B1 (ko) 1997-12-29
AU3674395A (en) 1996-05-06
KR960014333A (ko) 1996-05-22
US5856141A (en) 1999-01-05
WO1996012032A1 (en) 1996-04-25
ATE205539T1 (de) 2001-09-15

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Legal Events

Date Code Title Description
8332 No legal effect for de