ATE205539T1 - Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes - Google Patents

Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes

Info

Publication number
ATE205539T1
ATE205539T1 AT95934322T AT95934322T ATE205539T1 AT E205539 T1 ATE205539 T1 AT E205539T1 AT 95934322 T AT95934322 T AT 95934322T AT 95934322 T AT95934322 T AT 95934322T AT E205539 T1 ATE205539 T1 AT E205539T1
Authority
AT
Austria
Prior art keywords
cyclosporin
pct
fusant
strain
mutants
Prior art date
Application number
AT95934322T
Other languages
English (en)
Inventor
Jung Woo Kim
Kwang Moo Lee
Dong
Byoung Tack Choi
Jin Man Lee
Nak Kyu Sung
Kyeong Bok Min
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Application granted granted Critical
Publication of ATE205539T1 publication Critical patent/ATE205539T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95934322T 1994-10-18 1995-10-16 Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes ATE205539T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019940026689A KR0126610B1 (ko) 1994-10-18 1994-10-18 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
PCT/KR1995/000131 WO1996012032A1 (en) 1994-10-18 1995-10-16 Process for manufacturing cyclosporin a by highly productive fusant strain

Publications (1)

Publication Number Publication Date
ATE205539T1 true ATE205539T1 (de) 2001-09-15

Family

ID=19395381

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95934322T ATE205539T1 (de) 1994-10-18 1995-10-16 Herstellungsverfahren für cyclosporin a mittels eines hochproduktiven fusionsstammes

Country Status (9)

Country Link
US (1) US5856141A (de)
EP (1) EP0781348B1 (de)
JP (1) JP2983638B2 (de)
KR (1) KR0126610B1 (de)
AT (1) ATE205539T1 (de)
AU (1) AU3674395A (de)
CA (1) CA2202037C (de)
DE (1) DE69522695D1 (de)
WO (1) WO1996012032A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
PT1154759E (pt) 1998-12-30 2008-11-20 Dexcel Ltd Concentrado dispersível para administração de ciclosporina
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CA2401700A1 (en) 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of cyclosporin a
ATE355359T1 (de) * 2001-03-22 2006-03-15 Gakkou Houjin Kitasato Gakuen Selektionsmedia für beauveriolid i oder iii und verfahren zur selektiven herstellung dieser substanzen
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
US7226906B2 (en) * 2004-08-16 2007-06-05 Array Biopharma, Inc. Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943529A (en) * 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.
US5244790A (en) * 1991-12-17 1993-09-14 Kim Jong K Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents

Also Published As

Publication number Publication date
KR960014333A (ko) 1996-05-22
JPH10500580A (ja) 1998-01-20
JP2983638B2 (ja) 1999-11-29
US5856141A (en) 1999-01-05
AU3674395A (en) 1996-05-06
WO1996012032A1 (en) 1996-04-25
EP0781348B1 (de) 2001-09-12
EP0781348A1 (de) 1997-07-02
CA2202037C (en) 1999-03-30
KR0126610B1 (ko) 1997-12-29
DE69522695D1 (de) 2001-10-18
CA2202037A1 (en) 1996-04-25

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Legal Events

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