DE69517011D1 - Polymergestützte lösungs-synthese von oligosacchariden - Google Patents

Polymergestützte lösungs-synthese von oligosacchariden

Info

Publication number
DE69517011D1
DE69517011D1 DE69517011T DE69517011T DE69517011D1 DE 69517011 D1 DE69517011 D1 DE 69517011D1 DE 69517011 T DE69517011 T DE 69517011T DE 69517011 T DE69517011 T DE 69517011T DE 69517011 D1 DE69517011 D1 DE 69517011D1
Authority
DE
Germany
Prior art keywords
oligosaccharides
polymer
based solution
solution synthesis
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69517011T
Other languages
English (en)
Other versions
DE69517011T2 (de
Inventor
J Krepinsky
Paul Douglas
Martin Whitfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovations Foundation of University of Toronto
Original Assignee
Innovations Foundation of University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovations Foundation of University of Toronto filed Critical Innovations Foundation of University of Toronto
Application granted granted Critical
Publication of DE69517011D1 publication Critical patent/DE69517011D1/de
Publication of DE69517011T2 publication Critical patent/DE69517011T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
DE69517011T 1994-01-10 1995-01-10 Polymergestützte lösungs-synthese von oligosacchariden Expired - Fee Related DE69517011T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/179,096 US5616698A (en) 1994-01-10 1994-01-10 Polymer-supported solution synthesis of oligosaccharides
PCT/CA1995/000016 WO1995018814A2 (en) 1994-01-10 1995-01-10 Polymer-supported solution synthesis of oligosaccharides

Publications (2)

Publication Number Publication Date
DE69517011D1 true DE69517011D1 (de) 2000-06-21
DE69517011T2 DE69517011T2 (de) 2001-01-18

Family

ID=22655228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517011T Expired - Fee Related DE69517011T2 (de) 1994-01-10 1995-01-10 Polymergestützte lösungs-synthese von oligosacchariden

Country Status (6)

Country Link
US (1) US5616698A (de)
EP (1) EP0739349B1 (de)
AU (1) AU1410495A (de)
CA (1) CA2180979A1 (de)
DE (1) DE69517011T2 (de)
WO (1) WO1995018814A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE19642751A1 (de) * 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
EP0954612A2 (de) * 1996-11-06 1999-11-10 Sequenom, Inc. Dna-diagnostik mittels massenspektrometrie
EP1457496B1 (de) 1996-11-06 2014-01-15 Sequenom, Inc. Immobilisierung mit hoher Dichte von Nukleinsäuren
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5977328A (en) * 1997-03-12 1999-11-02 Krepinsky; Jiri J. Polyvalent carbohydrate molecules
PT1001961E (pt) * 1997-08-08 2005-04-29 Aventis Pharma Gmbh Derivados substituidos de tetra-hidropirano bem como processo para a sua preparacao
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
ATE346287T1 (de) 1999-07-16 2006-12-15 Univ Texas Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
WO2001038337A2 (en) * 1999-11-24 2001-05-31 Massachusetts Institute Of Technology Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
AU2001236597A1 (en) 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System System and method for the analysis of bodily fluids
WO2002061392A2 (en) * 2001-01-31 2002-08-08 Board Of Regents, The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
EP1502097A2 (de) 2002-04-26 2005-02-02 Board of Regents, The University of Texas System Verfahren und system zur detektion von kardialen risikofaktoren
EP1616021A4 (de) * 2002-12-30 2006-08-30 Gryphon Therapeutics Inc Multiplex-polymerligation
US7651868B2 (en) * 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
US8105849B2 (en) * 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP1910824A4 (de) 2005-05-31 2012-11-21 Labnow Inc Verfahren und zusammensetzungen in zusammenhang mit der erstellung und verwendung eines weissen blutbildes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE571756A (de) * 1957-04-02
US3173892A (en) * 1962-05-02 1965-03-16 Rohm & Haas Process of preparing reaction products of a halomethylated cross-linked copolymer, and resulting product
GB1002343A (en) * 1962-09-11 1965-08-25 Canadian Ind Process for hydroxyalkylating polymers containing carboxyl groups
SE394820B (sv) * 1970-01-23 1977-07-11 Exploaterings Ab Tbf Sett att till en i vatten oloslig polymer kovalent binda biologiskt verksamma elektrolyter, sasom aminosyror, peptider, proteiner, nukleotider och nukleinsyror genom reaktion med en sadan polymer innehallande ...
US3853708A (en) * 1970-01-23 1974-12-10 Exploaterings Ab Tbf Coupling biologically active substances to oxirane-containing polymers
US4085168A (en) * 1971-02-22 1978-04-18 Cpc International Inc. Chemically joined, phase separated self-cured hydrophilic thermoplastic graft copolymers and their preparation
US3941849A (en) * 1972-07-07 1976-03-02 The General Tire & Rubber Company Polyethers and method for making the same
DE2239401A1 (de) * 1972-08-10 1974-02-21 Basf Ag Block- bzw. pfropfcopolymere aus polyalkylenoxiden und vinylaromat- oder dienpolymerisaten
US4029720A (en) * 1972-08-10 1977-06-14 Badische Anilin- & Soda-Fabrik Aktiengesellschaft Block or graft copolymers of polyalkylene oxides and vinylaromatic or diene polymers
US4083834A (en) * 1973-02-12 1978-04-11 Japan Synthetic Rubber Co., Ltd. Process for producing polymer having functional groups at its chain terminals
DE2435642A1 (de) * 1974-07-24 1976-02-05 Hoffmann La Roche Traegermaterial
DE3380726D1 (en) * 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
WO1991016449A1 (en) * 1990-04-16 1991-10-31 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
CA2071178C (en) * 1992-06-12 2003-01-21 Jiri J. Krepinsky Polymer-supported solution synthesis of oligosaccharides

Also Published As

Publication number Publication date
DE69517011T2 (de) 2001-01-18
CA2180979A1 (en) 1995-07-13
WO1995018814A2 (en) 1995-07-13
WO1995018814A3 (en) 1995-08-31
EP0739349B1 (de) 2000-05-17
AU1410495A (en) 1995-08-01
US5616698A (en) 1997-04-01
EP0739349A1 (de) 1996-10-30

Similar Documents

Publication Publication Date Title
DE69517011T2 (de) Polymergestützte lösungs-synthese von oligosacchariden
DK0791016T3 (da) Polymersyntese
LV11178A (lv) 3-Ú4-(2-aminoetoksi) benzoil¾-2-aril-6-hidroksibenzoÚb¾tiofenu sintezes panemiens
ATE257846T1 (de) Herstellung von inulinhaltigen produkten
BR9507179A (pt) Derivados de 3-aril-4-hidróxi-delta3-dihidrotiofena
BR9510256A (pt) Derivados de ácido 3-aril-tetrônico
DE69603269D1 (de) Derivate von inulin
DE69532431D1 (de) Einzeltakt-Abtastverriegelungszelle
BR9502092A (pt) Conjunto de fechaduras
DE59609043D1 (de) Feste Lösungen von 1,4-Diketopyrrolopyrrolen
DE69804513D1 (de) Herstellung von zeolith-l
EE9600011A (et) Uudsed dialkoksü-püridinüül-bensimidasooli derivaadid
DE69502001T2 (de) Herstellung von uranoxid
DE69614175T2 (de) Funkrufempfänger
DE69502395D1 (de) Herstellung von triarylboran
DE69623986T2 (de) Herstellung von Allomelanin
FI972670A (fi) Uuudelleenkeittokelpoisia selluloosapitoisia materiaaleja
DE69221861T2 (de) Sequenzierung von oligosacchariden
DE59501871D1 (de) Monocarbonsäureamide von Polyaminen
DE69530358D1 (de) Reaktive Extrusion von Polymergelen
DE69707898T2 (de) Herstellung von bromierten indanen
DE9405878U1 (de) Rhenchodepressive Substanz
UA644S (uk) Мікро-еом широкого призначення
SE9502520D0 (sv) Dry-alarm
PT9043T (pt) Complemento de autoclismo

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee