DE69516529T2 - Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines amines - Google Patents
Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines aminesInfo
- Publication number
- DE69516529T2 DE69516529T2 DE69516529T DE69516529T DE69516529T2 DE 69516529 T2 DE69516529 T2 DE 69516529T2 DE 69516529 T DE69516529 T DE 69516529T DE 69516529 T DE69516529 T DE 69516529T DE 69516529 T2 DE69516529 T2 DE 69516529T2
- Authority
- DE
- Germany
- Prior art keywords
- thyrosine
- diiodo
- pct
- thyroxine
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9420705A GB9420705D0 (en) | 1994-10-14 | 1994-10-14 | Process |
| PCT/EP1995/004017 WO1996011904A1 (en) | 1994-10-14 | 1995-10-12 | Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69516529D1 DE69516529D1 (de) | 2000-05-31 |
| DE69516529T2 true DE69516529T2 (de) | 2000-08-10 |
Family
ID=10762819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69516529T Expired - Lifetime DE69516529T2 (de) | 1994-10-14 | 1995-10-12 | Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines amines |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5917087A (de) |
| EP (1) | EP0785921B1 (de) |
| AT (1) | ATE192137T1 (de) |
| AU (1) | AU3841395A (de) |
| CA (1) | CA2202094C (de) |
| DE (1) | DE69516529T2 (de) |
| DK (1) | DK0785921T3 (de) |
| ES (1) | ES2144639T3 (de) |
| GB (1) | GB9420705D0 (de) |
| GR (1) | GR3033346T3 (de) |
| PT (1) | PT785921E (de) |
| WO (1) | WO1996011904A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6638977B1 (en) | 1999-11-19 | 2003-10-28 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists |
| AU1624801A (en) | 1999-11-19 | 2001-05-30 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists related applications |
| JP2005515221A (ja) * | 2002-01-07 | 2005-05-26 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 超音波振盪を使用するアミノ酸の結晶化 |
| US20060008512A1 (en) * | 2004-07-07 | 2006-01-12 | Hooge Danny M | Composition and methods for improved animal performance |
| EP2338875A1 (de) | 2009-12-18 | 2011-06-29 | Bracco Imaging S.p.A | Herstellungsverfahren für Schilddrüsenhormone und Derivaten davon |
| CN102199103B (zh) * | 2011-03-24 | 2013-12-25 | 常州工程职业技术学院 | 一种改进的合成l-甲状腺素钠的方法 |
| US9428444B2 (en) * | 2013-07-24 | 2016-08-30 | Azico Biophore India Private Limited | Process for the preparation of levothyroxine sodium |
| NL2017110B1 (en) | 2016-07-05 | 2018-01-12 | Emp Levo Gmbh | Methods for the preparation of a levothyroxine solution |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2435947A (en) * | 1945-11-02 | 1948-02-10 | American Dairies Inc | Production of thyroxine from diiodotyrosine |
| US2889363A (en) * | 1955-12-09 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| US2889364A (en) * | 1957-05-03 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| JPS62184023A (ja) * | 1986-02-10 | 1987-08-12 | Asahi Chem Ind Co Ltd | ２，６−ジ置換フエノ−ル重合体の製造法 |
| JPH05271404A (ja) * | 1992-03-24 | 1993-10-19 | Sumitomo Chem Co Ltd | ポリフェニレンエーテルの製造方法 |
-
1994
- 1994-10-14 GB GB9420705A patent/GB9420705D0/en active Pending
-
1995
- 1995-10-12 US US08/817,325 patent/US5917087A/en not_active Expired - Lifetime
- 1995-10-12 ES ES95936478T patent/ES2144639T3/es not_active Expired - Lifetime
- 1995-10-12 AU AU38413/95A patent/AU3841395A/en not_active Abandoned
- 1995-10-12 WO PCT/EP1995/004017 patent/WO1996011904A1/en active IP Right Grant
- 1995-10-12 EP EP95936478A patent/EP0785921B1/de not_active Expired - Lifetime
- 1995-10-12 DE DE69516529T patent/DE69516529T2/de not_active Expired - Lifetime
- 1995-10-12 DK DK95936478T patent/DK0785921T3/da active
- 1995-10-12 CA CA2202094A patent/CA2202094C/en not_active Expired - Fee Related
- 1995-10-12 AT AT95936478T patent/ATE192137T1/de active
- 1995-10-12 PT PT95936478T patent/PT785921E/pt unknown
-
2000
- 2000-04-27 GR GR20000400963T patent/GR3033346T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5917087A (en) | 1999-06-29 |
| DE69516529D1 (de) | 2000-05-31 |
| DK0785921T3 (da) | 2000-08-07 |
| EP0785921A1 (de) | 1997-07-30 |
| AU3841395A (en) | 1996-05-06 |
| EP0785921B1 (de) | 2000-04-26 |
| CA2202094C (en) | 2010-02-09 |
| ATE192137T1 (de) | 2000-05-15 |
| ES2144639T3 (es) | 2000-06-16 |
| GR3033346T3 (en) | 2000-09-29 |
| PT785921E (pt) | 2000-08-31 |
| GB9420705D0 (en) | 1994-11-30 |
| WO1996011904A1 (en) | 1996-04-25 |
| CA2202094A1 (en) | 1996-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ABBOTT GMBH & CO. KG, 65205 WIESBADEN, DE |