ATE192137T1 - Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines amines - Google Patents
Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines aminesInfo
- Publication number
- ATE192137T1 ATE192137T1 AT95936478T AT95936478T ATE192137T1 AT E192137 T1 ATE192137 T1 AT E192137T1 AT 95936478 T AT95936478 T AT 95936478T AT 95936478 T AT95936478 T AT 95936478T AT E192137 T1 ATE192137 T1 AT E192137T1
- Authority
- AT
- Austria
- Prior art keywords
- thyroxine
- thyrosine
- diiodo
- pct
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9420705A GB9420705D0 (en) | 1994-10-14 | 1994-10-14 | Process |
| PCT/EP1995/004017 WO1996011904A1 (en) | 1994-10-14 | 1995-10-12 | Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE192137T1 true ATE192137T1 (de) | 2000-05-15 |
Family
ID=10762819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95936478T ATE192137T1 (de) | 1994-10-14 | 1995-10-12 | Verfahren zur herstellung von natrium-1-thyroxin durch oxidative kupplung von diiodo-l-thyrosine, katalysiert durch ein mangan-salz und in gegenwart eines amines |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5917087A (de) |
| EP (1) | EP0785921B1 (de) |
| AT (1) | ATE192137T1 (de) |
| AU (1) | AU3841395A (de) |
| CA (1) | CA2202094C (de) |
| DE (1) | DE69516529T2 (de) |
| DK (1) | DK0785921T3 (de) |
| ES (1) | ES2144639T3 (de) |
| GB (1) | GB9420705D0 (de) |
| GR (1) | GR3033346T3 (de) |
| PT (1) | PT785921E (de) |
| WO (1) | WO1996011904A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1624801A (en) | 1999-11-19 | 2001-05-30 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists related applications |
| US6638977B1 (en) | 1999-11-19 | 2003-10-28 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists |
| JP2005515221A (ja) * | 2002-01-07 | 2005-05-26 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 超音波振盪を使用するアミノ酸の結晶化 |
| US20060008512A1 (en) * | 2004-07-07 | 2006-01-12 | Hooge Danny M | Composition and methods for improved animal performance |
| EP2338875A1 (de) | 2009-12-18 | 2011-06-29 | Bracco Imaging S.p.A | Herstellungsverfahren für Schilddrüsenhormone und Derivaten davon |
| CN102199103B (zh) * | 2011-03-24 | 2013-12-25 | 常州工程职业技术学院 | 一种改进的合成l-甲状腺素钠的方法 |
| EP3024326B1 (de) * | 2013-07-24 | 2018-12-12 | Azico Biophore India Private Limited | Neuartiges verfahren zur herstellung von levothyroxin-natrium |
| NL2017110B1 (en) | 2016-07-05 | 2018-01-12 | Emp Levo Gmbh | Methods for the preparation of a levothyroxine solution |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2435947A (en) * | 1945-11-02 | 1948-02-10 | American Dairies Inc | Production of thyroxine from diiodotyrosine |
| US2889363A (en) * | 1955-12-09 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| US2889364A (en) * | 1957-05-03 | 1959-06-02 | Baxter Laboratories Inc | Process for producing thyroxine |
| JPS62184023A (ja) * | 1986-02-10 | 1987-08-12 | Asahi Chem Ind Co Ltd | ２，６−ジ置換フエノ−ル重合体の製造法 |
| JPH05271404A (ja) * | 1992-03-24 | 1993-10-19 | Sumitomo Chem Co Ltd | ポリフェニレンエーテルの製造方法 |
-
1994
- 1994-10-14 GB GB9420705A patent/GB9420705D0/en active Pending
-
1995
- 1995-10-12 AT AT95936478T patent/ATE192137T1/de active
- 1995-10-12 PT PT95936478T patent/PT785921E/pt unknown
- 1995-10-12 DK DK95936478T patent/DK0785921T3/da active
- 1995-10-12 US US08/817,325 patent/US5917087A/en not_active Expired - Lifetime
- 1995-10-12 CA CA2202094A patent/CA2202094C/en not_active Expired - Fee Related
- 1995-10-12 ES ES95936478T patent/ES2144639T3/es not_active Expired - Lifetime
- 1995-10-12 WO PCT/EP1995/004017 patent/WO1996011904A1/en not_active Ceased
- 1995-10-12 AU AU38413/95A patent/AU3841395A/en not_active Abandoned
- 1995-10-12 EP EP95936478A patent/EP0785921B1/de not_active Expired - Lifetime
- 1995-10-12 DE DE69516529T patent/DE69516529T2/de not_active Expired - Lifetime
-
2000
- 2000-04-27 GR GR20000400963T patent/GR3033346T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2202094C (en) | 2010-02-09 |
| AU3841395A (en) | 1996-05-06 |
| EP0785921A1 (de) | 1997-07-30 |
| CA2202094A1 (en) | 1996-04-25 |
| US5917087A (en) | 1999-06-29 |
| WO1996011904A1 (en) | 1996-04-25 |
| EP0785921B1 (de) | 2000-04-26 |
| GR3033346T3 (en) | 2000-09-29 |
| GB9420705D0 (en) | 1994-11-30 |
| PT785921E (pt) | 2000-08-31 |
| DE69516529T2 (de) | 2000-08-10 |
| DE69516529D1 (de) | 2000-05-31 |
| DK0785921T3 (da) | 2000-08-07 |
| ES2144639T3 (es) | 2000-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |