DE69510543T2 - Gel-mikrosphären, verfahren zu deren herstellung sowie ihre verwendungen - Google Patents

Gel-mikrosphären, verfahren zu deren herstellung sowie ihre verwendungen

Info

Publication number
DE69510543T2
DE69510543T2 DE69510543T DE69510543T DE69510543T2 DE 69510543 T2 DE69510543 T2 DE 69510543T2 DE 69510543 T DE69510543 T DE 69510543T DE 69510543 T DE69510543 T DE 69510543T DE 69510543 T2 DE69510543 T2 DE 69510543T2
Authority
DE
Germany
Prior art keywords
gelified
polar
microspheres
production
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69510543T
Other languages
English (en)
Other versions
DE69510543D1 (de
Inventor
Jacques Hauton
Jean-Pierre Salles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LIPOGEL ALLAUCH
Original Assignee
LIPOGEL ALLAUCH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPOGEL ALLAUCH filed Critical LIPOGEL ALLAUCH
Publication of DE69510543D1 publication Critical patent/DE69510543D1/de
Application granted granted Critical
Publication of DE69510543T2 publication Critical patent/DE69510543T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69510543T 1994-04-12 1995-04-12 Gel-mikrosphären, verfahren zu deren herstellung sowie ihre verwendungen Expired - Fee Related DE69510543T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404294A FR2718369B1 (fr) 1994-04-12 1994-04-12 Microsphères gélifiées, leur procédé de préparation et leurs applications.
PCT/FR1995/000473 WO1995027477A1 (fr) 1994-04-12 1995-04-12 Microspheres gelifiees, leur procede de preparation et leurs applications

Publications (2)

Publication Number Publication Date
DE69510543D1 DE69510543D1 (de) 1999-08-05
DE69510543T2 true DE69510543T2 (de) 2000-01-13

Family

ID=9461987

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69510543T Expired - Fee Related DE69510543T2 (de) 1994-04-12 1995-04-12 Gel-mikrosphären, verfahren zu deren herstellung sowie ihre verwendungen

Country Status (18)

Country Link
US (2) US5945120A (de)
EP (1) EP0755248B1 (de)
JP (1) JPH10502332A (de)
KR (1) KR970702027A (de)
AT (1) ATE181665T1 (de)
AU (1) AU692860B2 (de)
BR (1) BR9507350A (de)
CA (1) CA2187551A1 (de)
DE (1) DE69510543T2 (de)
DK (1) DK0755248T3 (de)
ES (1) ES2135728T3 (de)
FI (1) FI964073A (de)
FR (1) FR2718369B1 (de)
GR (1) GR3031108T3 (de)
HU (1) HUT76439A (de)
NZ (1) NZ284825A (de)
RU (1) RU2154465C2 (de)
WO (1) WO1995027477A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757768B1 (fr) * 1996-12-27 1999-04-02 Biovector Therapeutics Sa Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant
FR2764508B1 (fr) * 1997-06-11 2000-10-20 Lipogel Sarl Nouveaux vecteurs liposomaux de principes actifs
FR2764507B1 (fr) * 1997-06-11 2000-10-20 Lipogel Sarl Compositions pulverulentes de liposomes unilamellaires, leur procede de preparation et leurs applications comme complements nutritionnels et comme complements nutritionnels et comme medicaments
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
EA200600709A1 (ru) * 2005-12-29 2007-06-29 Дмитрий Александрович Исаев Способ хранения сперматозоидов и продукт для искусственного оплодотворения (варианты)
WO2012155048A1 (en) * 2011-05-11 2012-11-15 Wisconsin Alumni Research Foundation Liposome-encapsulated hydrogels for use in a drug delivery system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US5008109A (en) * 1984-05-25 1991-04-16 Vestar, Inc. Vesicle stabilization
US4740375A (en) * 1985-02-25 1988-04-26 Technology Unlimited, Inc. Gelcores
US4839111A (en) * 1987-02-02 1989-06-13 The University Of Tennessee Research Corporation Preparation of solid core liposomes
US4765143A (en) * 1987-02-04 1988-08-23 Cbi Research Corporation Power plant using CO2 as a working fluid
FR2620333B1 (fr) * 1987-09-15 1990-01-05 Inst Nat Sante Rech Med Liposomes, leur procede de preparation et application desdits liposomes comme vecteur de produits
US5104736A (en) * 1988-03-03 1992-04-14 Micro-Pak, Inc. Reinforced paucilamellar lipid vesicles
US5464629A (en) 1993-11-16 1995-11-07 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes

Also Published As

Publication number Publication date
KR970702027A (ko) 1997-05-13
FR2718369B1 (fr) 1996-06-21
NZ284825A (en) 1998-04-27
DK0755248T3 (da) 2000-01-31
EP0755248A1 (de) 1997-01-29
MX9604757A (es) 1998-05-31
GR3031108T3 (en) 1999-12-31
DE69510543D1 (de) 1999-08-05
ES2135728T3 (es) 1999-11-01
CA2187551A1 (fr) 1995-10-19
US5945120A (en) 1999-08-31
FR2718369A1 (fr) 1995-10-13
AU692860B2 (en) 1998-06-18
AU2347595A (en) 1995-10-30
ATE181665T1 (de) 1999-07-15
BR9507350A (pt) 1997-09-23
RU2154465C2 (ru) 2000-08-20
US6221387B1 (en) 2001-04-24
HUT76439A (en) 1997-08-28
EP0755248B1 (de) 1999-06-30
WO1995027477A1 (fr) 1995-10-19
FI964073A (fi) 1996-10-14
FI964073A0 (fi) 1996-10-11
HU9602801D0 (en) 1996-11-28
JPH10502332A (ja) 1998-03-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee