DE69508449T2 - Herstellung von vernetzten Anionaustaucherpartikeln - Google Patents

Herstellung von vernetzten Anionaustaucherpartikeln

Info

Publication number
DE69508449T2
DE69508449T2 DE69508449T DE69508449T DE69508449T2 DE 69508449 T2 DE69508449 T2 DE 69508449T2 DE 69508449 T DE69508449 T DE 69508449T DE 69508449 T DE69508449 T DE 69508449T DE 69508449 T2 DE69508449 T2 DE 69508449T2
Authority
DE
Germany
Prior art keywords
manufacture
cross
anion exchange
exchange particles
linked anion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69508449T
Other languages
English (en)
Other versions
DE69508449D1 (de
Inventor
Paul Edward Bliem
Larry Wayne Steffier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rohm and Haas Co
Original Assignee
Rohm and Haas Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohm and Haas Co filed Critical Rohm and Haas Co
Publication of DE69508449D1 publication Critical patent/DE69508449D1/de
Application granted granted Critical
Publication of DE69508449T2 publication Critical patent/DE69508449T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F120/52—Amides or imides
    • C08F120/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F120/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69508449T 1994-01-24 1995-01-11 Herstellung von vernetzten Anionaustaucherpartikeln Expired - Lifetime DE69508449T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/185,534 US5414068A (en) 1994-01-24 1994-01-24 Crosslinked anion exchange particles and method for producing the particles

Publications (2)

Publication Number Publication Date
DE69508449D1 DE69508449D1 (de) 1999-04-29
DE69508449T2 true DE69508449T2 (de) 1999-11-25

Family

ID=22681387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69508449T Expired - Lifetime DE69508449T2 (de) 1994-01-24 1995-01-11 Herstellung von vernetzten Anionaustaucherpartikeln

Country Status (9)

Country Link
US (3) US5414068A (de)
EP (1) EP0665245B1 (de)
JP (1) JP4262785B2 (de)
KR (1) KR950031088A (de)
CN (1) CN1115768A (de)
CA (1) CA2139909A1 (de)
DE (1) DE69508449T2 (de)
HU (1) HUT70636A (de)
RU (1) RU95101024A (de)

Families Citing this family (51)

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US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6491903B1 (en) * 1996-06-27 2002-12-10 Washington University Particles comprising amphiphilic copolymers
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
FR2766712B1 (fr) * 1997-08-01 1999-10-22 Aguettant Lab Composition de preference solution antioxydante et medicaments en faisant application
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6406817B2 (en) * 1998-07-01 2002-06-18 Ube Industries, Ltd. Crosslinked polymer, electrolyte using the polymer, and nonaqueous secondary battery using the electrolyte
US6323306B1 (en) 1998-09-08 2001-11-27 Ciba Specialty Chemicals Water Treatments Ltd. Preparation of water-soluble cross-linked cationic polymers
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20030091530A1 (en) * 2000-03-13 2003-05-15 Takeshi Goto Preventives and/or remedies for hyperphosphatemia
US8173114B2 (en) * 2000-11-28 2012-05-08 Mitsubishi Tanabe Pharma Corporation Excretion accelerator for accumulative chlorine compound
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
JP4117873B2 (ja) * 2002-02-05 2008-07-16 東京応化工業株式会社 ネガ型感光性樹脂組成物
WO2005041657A1 (en) 2003-10-20 2005-05-12 Framework Therapeutics, L.L.C. Zeolite molecular sieves for the removal of toxins
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
JP2008526771A (ja) * 2004-12-30 2008-07-24 ジェンザイム コーポレーション 高リン酸血症のための亜鉛含有処置
WO2007027566A2 (en) * 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
PT1924246E (pt) 2005-09-15 2016-02-10 Genzyme Corp Formulação sachê para polímeros com funcionalidade amina
JP2009514966A (ja) * 2005-11-08 2009-04-09 ジェンザイム・コーポレーション 高リン血症のためのマグネシウム含有重合体
EP2016114A2 (de) * 2006-05-05 2009-01-21 Genzyme Corporation Aminkondensationspolymere als phosphatkomplexbildner
WO2008005217A2 (en) * 2006-07-05 2008-01-10 Genzyme Corporation Iron(ii)-containing treatments for hyperphosphatemia
EP2049014A2 (de) * 2006-07-18 2009-04-22 Genzyme Corporation Amindendrimere
JP2010504975A (ja) 2006-09-29 2010-02-18 ゲンズイメ コーポレーション アミドデンドリマー組成物
US8414927B2 (en) * 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
BRPI0720234A2 (pt) 2006-12-14 2013-12-24 Genzyme Corp Composição farmacêutica
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
JP2010520285A (ja) * 2007-03-08 2010-06-10 ゲンズイメ コーポレーション スルホンポリマー組成物
EP2152277A1 (de) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amin-dendrimer-zusammensetzungen
EP2016947A1 (de) * 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Neuartiges Verfahren zur Herstellung vernetzter Poly(allylamin-)Polymere in einem einzigen Schritt
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
AU2011220748B2 (en) 2010-02-24 2015-11-05 Relypsa, Inc. Amine polymers for use as bile acid sequestrants
US9181364B2 (en) 2010-02-24 2015-11-10 Relypsa, Inc. Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants
WO2011106545A1 (en) 2010-02-24 2011-09-01 Relypsa, Inc. Polyimidazoles for use as bile acid sequestrants
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL241315A (de) 1958-07-18
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
DE2258868A1 (de) * 1972-12-01 1974-06-06 Basf Ag Verfahren zur herstellung quaternaerer stickstoffhaltiger polymerisate
US4046750A (en) * 1974-09-30 1977-09-06 California Institute Of Technology Ionene modified small polymeric beads
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
US5300288A (en) * 1991-04-05 1994-04-05 Rohm And Haas Company Composition and method for controlling cholesterol
JPH0539961A (ja) * 1991-08-02 1993-02-19 Mitsubishi Electric Corp 圧縮機容量制御装置
ATE146193T1 (de) * 1992-07-22 1996-12-15 Hoechst Ag Vernetzte, stickstoffhaltige vinylcopolymere, verfahren zu ihrer herstellung sowie die verwendung dieser verbindungen
ES2110543T3 (es) * 1992-07-22 1998-02-16 Hoechst Ag Derivados de poli(vinil-aminas) que tienen centros hidrofilos, procedimiento para su preparacion asi como la utilizacion de los compuestos como medicamentos, vehiculos de sustancias activas e ingredientes auxiliares para alimentos.

Also Published As

Publication number Publication date
HUT70636A (en) 1995-10-30
EP0665245A1 (de) 1995-08-02
US5414068A (en) 1995-05-09
KR950031088A (ko) 1995-12-18
DE69508449D1 (de) 1999-04-29
US5500212A (en) 1996-03-19
CN1115768A (zh) 1996-01-31
HU9500199D0 (en) 1995-03-28
RU95101024A (ru) 1996-10-27
CA2139909A1 (en) 1995-07-25
JP4262785B2 (ja) 2009-05-13
US5453429A (en) 1995-09-26
EP0665245B1 (de) 1999-03-24
JPH07206688A (ja) 1995-08-08

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Legal Events

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