DE69433685D1 - Unterdrückung von inhibitoren - Google Patents
Unterdrückung von inhibitorenInfo
- Publication number
- DE69433685D1 DE69433685D1 DE69433685T DE69433685T DE69433685D1 DE 69433685 D1 DE69433685 D1 DE 69433685D1 DE 69433685 T DE69433685 T DE 69433685T DE 69433685 T DE69433685 T DE 69433685T DE 69433685 D1 DE69433685 D1 DE 69433685D1
- Authority
- DE
- Germany
- Prior art keywords
- ipnme
- methods
- compounds
- malignant tumour
- suppression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4704—Inhibitors; Supressors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK85193 | 1993-07-16 | ||
DK93851A DK85193D0 (da) | 1993-07-16 | 1993-07-16 | Suppression of inhibitors |
PCT/DK1994/000288 WO1995002413A1 (en) | 1993-07-16 | 1994-07-18 | Suppression of inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433685D1 true DE69433685D1 (de) | 2004-05-13 |
DE69433685T2 DE69433685T2 (de) | 2005-03-03 |
Family
ID=8098263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433685T Expired - Lifetime DE69433685T2 (de) | 1993-07-16 | 1994-07-18 | Unterdrückung von inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (4) | US6224865B1 (de) |
EP (1) | EP0712312B1 (de) |
JP (1) | JPH10500097A (de) |
AT (1) | ATE263569T1 (de) |
AU (1) | AU7183394A (de) |
DE (1) | DE69433685T2 (de) |
DK (1) | DK85193D0 (de) |
ES (1) | ES2217268T3 (de) |
WO (1) | WO1995002413A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK85193D0 (da) * | 1993-07-16 | 1993-07-16 | Cancerforskningsfondet Af 1989 | Suppression of inhibitors |
US6811995B1 (en) * | 1996-04-26 | 2004-11-02 | Children's Medical Center Corporation | Non-invasive enzyme screen for cancer |
US5994309A (en) | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
US6750201B1 (en) | 1997-10-17 | 2004-06-15 | The Trustees Of The University Of Pennsylvania | Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator |
CA2306953A1 (en) * | 1997-10-17 | 1999-04-29 | Abd Al-Roof Higazi | Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator |
US6841153B1 (en) * | 1998-10-02 | 2005-01-11 | University Of Florida | Prevention of adhesions |
JP2002537346A (ja) * | 1999-02-22 | 2002-11-05 | エリック・エフ・バーンスタイン | 光老化の保護用組成物および保護方法 |
US6986881B1 (en) * | 1999-06-04 | 2006-01-17 | Dana-Farber Cancer Institute, Inc. | Identification of compounds that modify transcriptional responses to hypoxia |
ATE524739T1 (de) * | 2002-02-13 | 2011-09-15 | American Diagnostica Inc | Verfahren zur auswahl von behandlungsschemata und vorhersage von behandlungsresultaten bei krebspatienten |
US20050244893A1 (en) * | 2004-04-16 | 2005-11-03 | Wyeth | Novel method for determination of plasminogen activator inhibitor |
WO2006055727A2 (en) * | 2004-11-18 | 2006-05-26 | The Board Of Trustees Of The University Of Illinois | MULTICISTRONIC siRNA CONSTRUCTS TO INHIBIT TUMORS |
US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
EP2022500A4 (de) * | 2006-06-01 | 2010-11-24 | Jp Agency Of Nat Cancer Ct | Tumor-suppressor |
EP2198055A4 (de) * | 2007-09-07 | 2012-04-18 | Cisthera Inc | Humanisierte pai-1-antikörper |
US7981415B2 (en) * | 2007-09-07 | 2011-07-19 | Cisthera, Inc. | Humanized PAI-1 antibodies |
US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
CN112142845A (zh) * | 2013-08-13 | 2020-12-29 | 赛诺菲 | 纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途 |
JP2018517892A (ja) | 2015-04-10 | 2018-07-05 | アプライド プロテオミクス,インク. | 結腸直腸癌と進行腺腫を検知するためのタンパク質バイオマーカーパネル |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK319685A (da) * | 1985-07-12 | 1987-01-13 | Fonden Til Fremme Af Eksperime | Monoklonale antistoffer, fremgangsmaade til frembringelse af antistofferne, hybridomaceller, der producerer antistofferne, og anvendelse af antistofferne |
US4906457A (en) * | 1988-09-06 | 1990-03-06 | Washington State University Research Foundation, Inc. | Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer |
DK0627940T3 (da) * | 1992-03-05 | 2003-09-01 | Univ Texas | Anvendelse af immunokonjugater til diagnose og/eller terapi af vaskulariserede tumorer |
GB9217331D0 (en) | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
US5744442A (en) * | 1992-08-26 | 1998-04-28 | Bristol Meyers Squibb Company | Regulation of cellular invasiveness |
DK85193D0 (da) * | 1993-07-16 | 1993-07-16 | Cancerforskningsfondet Af 1989 | Suppression of inhibitors |
US5800814A (en) | 1994-04-22 | 1998-09-01 | Oklahoma Medical Research Foundation | Method for inhibition of breast tumor growth |
GB9410387D0 (en) | 1994-05-24 | 1994-07-13 | Xenova Ltd | Pharmaceutical compounds |
ES2193240T3 (es) | 1996-05-15 | 2003-11-01 | Altarex Inc | Metodo y composicion para reconformar antigenos multi-epitopicos para iniciar una respuesta inmune. |
EP1381631B1 (de) * | 2001-04-24 | 2010-10-13 | Bayer Corporation | Menschliche antikörper gegen timp-1 |
WO2005094863A1 (en) * | 2004-03-30 | 2005-10-13 | Den Kgl.Veterinær-Og Landbohøjskole | Improvements in cancer treatment and cancer treatment efficacy prediction by blocking and decting protease inhibitors |
-
1993
- 1993-07-16 DK DK93851A patent/DK85193D0/da not_active Application Discontinuation
-
1994
- 1994-07-18 JP JP7504300A patent/JPH10500097A/ja active Pending
- 1994-07-18 ES ES94920904T patent/ES2217268T3/es not_active Expired - Lifetime
- 1994-07-18 AU AU71833/94A patent/AU7183394A/en not_active Abandoned
- 1994-07-18 EP EP94920904A patent/EP0712312B1/de not_active Expired - Lifetime
- 1994-07-18 WO PCT/DK1994/000288 patent/WO1995002413A1/en active IP Right Grant
- 1994-07-18 US US08/583,129 patent/US6224865B1/en not_active Expired - Lifetime
- 1994-07-18 DE DE69433685T patent/DE69433685T2/de not_active Expired - Lifetime
- 1994-07-18 AT AT94920904T patent/ATE263569T1/de not_active IP Right Cessation
-
2001
- 2001-04-18 US US09/836,323 patent/US20010034327A1/en not_active Abandoned
-
2003
- 2003-01-02 US US10/336,513 patent/US20030096755A1/en not_active Abandoned
-
2007
- 2007-12-26 US US11/964,334 patent/US20080166354A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6224865B1 (en) | 2001-05-01 |
AU7183394A (en) | 1995-02-13 |
ATE263569T1 (de) | 2004-04-15 |
DE69433685T2 (de) | 2005-03-03 |
WO1995002413A1 (en) | 1995-01-26 |
ES2217268T3 (es) | 2004-11-01 |
EP0712312A1 (de) | 1996-05-22 |
JPH10500097A (ja) | 1998-01-06 |
US20010034327A1 (en) | 2001-10-25 |
US20030096755A1 (en) | 2003-05-22 |
DK85193D0 (da) | 1993-07-16 |
US20080166354A1 (en) | 2008-07-10 |
EP0712312B1 (de) | 2004-04-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |