DE69432055T2 - Verwendung von einem mittel, das tyrosinphosphorylierung moduliert, zur modulation der durchlässigkeit einer physiologischen sperrschicht - Google Patents
Verwendung von einem mittel, das tyrosinphosphorylierung moduliert, zur modulation der durchlässigkeit einer physiologischen sperrschichtInfo
- Publication number
- DE69432055T2 DE69432055T2 DE69432055T DE69432055T DE69432055T2 DE 69432055 T2 DE69432055 T2 DE 69432055T2 DE 69432055 T DE69432055 T DE 69432055T DE 69432055 T DE69432055 T DE 69432055T DE 69432055 T2 DE69432055 T2 DE 69432055T2
- Authority
- DE
- Germany
- Prior art keywords
- permeability
- blood
- brain barrier
- modulating
- modules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/285—Arsenic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939323884A GB9323884D0 (en) | 1993-11-19 | 1993-11-19 | Physiological modulation |
PCT/GB1994/002543 WO1995013820A1 (en) | 1993-11-19 | 1994-11-18 | Use of an agent which modulates tyrosine phosphorylation for modulating the permeability of a psychological barrier |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432055D1 DE69432055D1 (de) | 2003-02-27 |
DE69432055T2 true DE69432055T2 (de) | 2003-11-06 |
Family
ID=10745427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432055T Expired - Fee Related DE69432055T2 (de) | 1993-11-19 | 1994-11-18 | Verwendung von einem mittel, das tyrosinphosphorylierung moduliert, zur modulation der durchlässigkeit einer physiologischen sperrschicht |
Country Status (7)
Country | Link |
---|---|
US (2) | US6312686B1 (de) |
EP (1) | EP0728009B1 (de) |
JP (1) | JPH09505076A (de) |
AT (1) | ATE231396T1 (de) |
DE (1) | DE69432055T2 (de) |
GB (1) | GB9323884D0 (de) |
WO (1) | WO1995013820A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9423372D0 (en) | 1994-11-18 | 1995-01-11 | Eisai London Res Lab Ltd | Proteins and their uses |
GB9525703D0 (en) * | 1995-12-15 | 1996-02-14 | Ciba Geigy Ag | Screening method |
GB9620390D0 (en) | 1996-09-30 | 1996-11-13 | Eisai London Res Lab Ltd | Substances and their uses |
AU3378599A (en) * | 1998-04-03 | 1999-10-25 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
US7398119B2 (en) * | 1998-07-13 | 2008-07-08 | Childrens Hospital Los Angeles | Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals |
US6574501B2 (en) * | 1998-07-13 | 2003-06-03 | Childrens Hospital Los Angeles | Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye |
EP1137946B1 (de) * | 1998-12-11 | 2005-10-19 | Eisai Co., Ltd. | Verwendung des vaskularen endothelialen wachstumsfaktors (vegf) |
US6174875B1 (en) | 1999-04-01 | 2001-01-16 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
US6924109B2 (en) * | 1999-07-30 | 2005-08-02 | Agy Therapeutics, Inc. | High-throughput transcriptome and functional validation analysis |
US6841351B2 (en) * | 1999-07-30 | 2005-01-11 | Agy Therapeutics, Inc. | High-throughput transcriptome and functional validation analysis |
US6961599B2 (en) * | 2001-01-09 | 2005-11-01 | Childrens Hospital Los Angeles | Identifying or measuring selected substances or toxins in a subject using resonant raman signals |
JP2004537282A (ja) * | 2001-03-23 | 2004-12-16 | エージーワイ セラピューティクス | 脳腫瘍の処置及び可視化における生体分子標的の使用法 |
US20030118585A1 (en) * | 2001-10-17 | 2003-06-26 | Agy Therapeutics | Use of protein biomolecular targets in the treatment and visualization of brain tumors |
AU2002303804A1 (en) * | 2001-05-18 | 2002-12-03 | The Scripps Research Institute | Retroviral vectors and methods of using same |
GB2396106B (en) * | 2002-12-12 | 2006-11-15 | Johnson & Johnson Medical Ltd | Wound dressings comprising enzyme inhibitors |
US7485706B2 (en) * | 2003-07-30 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Neurodegenerative protein aggregation inhibition methods and compounds |
US20050074506A1 (en) * | 2003-10-02 | 2005-04-07 | Brainsgate Ltd. | Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders |
US8529889B2 (en) * | 2004-06-29 | 2013-09-10 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
GEP20115226B (en) * | 2005-04-26 | 2011-06-10 | Pfizer | P-cadherin antibodies |
WO2009114533A2 (en) * | 2008-03-10 | 2009-09-17 | Cornell University | Modulation of blood brain barrier permeability |
US20130079682A1 (en) * | 2011-09-25 | 2013-03-28 | David J. Mischelevich | Ultrasound-neuromodulation techniques for control of permeability of the blood-brain barrier |
US20130224110A1 (en) * | 2010-09-16 | 2013-08-29 | Cornell University | Use of adenosine receptor signaling to modulate permeability of blood-brain barrier |
AU2015347015B2 (en) | 2014-11-14 | 2019-02-14 | Novartis Ag | Antibody drug conjugates |
CN109432410A (zh) * | 2018-12-19 | 2019-03-08 | 上海康孕企业管理合伙企业(有限合伙) | 血红素在预防和/或改善高原反应的药物、食品及保健食品中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0494175A4 (en) * | 1989-09-27 | 1993-05-05 | Athena Neurosciences, Inc. | Compositions for cell adhesion inhibition and methods of use |
JPH0413631A (ja) * | 1990-04-27 | 1992-01-17 | Tonen Corp | アナカルジウム・オクシデンタレ由来の物質 |
US5155031A (en) * | 1990-06-07 | 1992-10-13 | Posner Barry I | Use of pervanadate as an inhibitor of phosphotyrosine phosphatase |
-
1993
- 1993-11-19 GB GB939323884A patent/GB9323884D0/en active Pending
-
1994
- 1994-11-18 JP JP7514314A patent/JPH09505076A/ja not_active Ceased
- 1994-11-18 DE DE69432055T patent/DE69432055T2/de not_active Expired - Fee Related
- 1994-11-18 EP EP95901509A patent/EP0728009B1/de not_active Expired - Lifetime
- 1994-11-18 WO PCT/GB1994/002543 patent/WO1995013820A1/en active IP Right Grant
- 1994-11-18 AT AT95901509T patent/ATE231396T1/de not_active IP Right Cessation
- 1994-11-18 US US08/648,182 patent/US6312686B1/en not_active Expired - Fee Related
-
2001
- 2001-05-04 US US09/848,353 patent/US20020032151A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20020032151A1 (en) | 2002-03-14 |
US6312686B1 (en) | 2001-11-06 |
EP0728009B1 (de) | 2003-01-22 |
GB9323884D0 (en) | 1994-01-05 |
DE69432055D1 (de) | 2003-02-27 |
WO1995013820A1 (en) | 1995-05-26 |
JPH09505076A (ja) | 1997-05-20 |
EP0728009A1 (de) | 1996-08-28 |
ATE231396T1 (de) | 2003-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP |
|
8339 | Ceased/non-payment of the annual fee |