EP0494175A4 - Compositions for cell adhesion inhibition and methods of use - Google Patents

Compositions for cell adhesion inhibition and methods of use

Info

Publication number
EP0494175A4
EP0494175A4 EP19900913684 EP90913684A EP0494175A4 EP 0494175 A4 EP0494175 A4 EP 0494175A4 EP 19900913684 EP19900913684 EP 19900913684 EP 90913684 A EP90913684 A EP 90913684A EP 0494175 A4 EP0494175 A4 EP 0494175A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
cell adhesion
adhesion inhibition
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900913684
Other versions
EP0494175A1 (en
Inventor
Lee L. Dr. C/O Eisai London Reasearch Lab Rubin
Chen W. Liaw
Kevin J. Tomaselli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Athena Neurosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athena Neurosciences Inc filed Critical Athena Neurosciences Inc
Publication of EP0494175A1 publication Critical patent/EP0494175A1/en
Publication of EP0494175A4 publication Critical patent/EP0494175A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19900913684 1989-09-27 1990-09-13 Compositions for cell adhesion inhibition and methods of use Withdrawn EP0494175A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41333289A 1989-09-27 1989-09-27
US413332 1989-09-27
US57126790A 1990-08-23 1990-08-23
US571267 1990-08-23

Publications (2)

Publication Number Publication Date
EP0494175A1 EP0494175A1 (en) 1992-07-15
EP0494175A4 true EP0494175A4 (en) 1993-05-05

Family

ID=27022149

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900913684 Withdrawn EP0494175A4 (en) 1989-09-27 1990-09-13 Compositions for cell adhesion inhibition and methods of use

Country Status (4)

Country Link
EP (1) EP0494175A4 (en)
JP (1) JPH05500504A (en)
CA (1) CA2067183A1 (en)
WO (1) WO1991004745A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033665A (en) * 1989-09-27 2000-03-07 Elan Pharmaceuticals, Inc. Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
CA2090427A1 (en) * 1990-08-27 1992-02-28 Cetus Oncology Corporation Cd18 peptide medicaments for the treatment of disease
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5827819A (en) * 1990-11-01 1998-10-27 Oregon Health Sciences University Covalent polar lipid conjugates with neurologically active compounds for targeting
US5597725A (en) * 1992-04-17 1997-01-28 Doheny Eye Institute Cadherin-specific antibodies and hybridoma cell lines
EP0604603A4 (en) 1992-04-17 1996-09-25 Doheny Eye Inst Cadherin materials and methods.
US5646250A (en) * 1992-04-17 1997-07-08 Doheny Eye Institute Cadherin polypeptides
WO1994011401A1 (en) * 1992-11-17 1994-05-26 Yale University Human homolog of the e-cadherin gene and methods based thereon
US5643781A (en) * 1992-12-29 1997-07-01 Doheny Eye Institute DNA encoding protocadherin-42
US5798224A (en) 1992-12-29 1998-08-25 Doheny Eye Institute Nucleic acids encoding protocadherin
GB9323884D0 (en) * 1993-11-19 1994-01-05 Eisai London Res Lab Ltd Physiological modulation
US6031072A (en) 1996-07-12 2000-02-29 Mcgill University Compounds and methods for modulating cell adhesion
US6465427B1 (en) 1996-07-12 2002-10-15 Mcgill University Compounds and methods for modulating cell adhesion
US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
US6333307B1 (en) * 1996-07-12 2001-12-25 Mcgill University Compounds and method for modulating neurite outgrowth
US20020168761A1 (en) 2000-01-24 2002-11-14 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US6417325B1 (en) 1996-07-12 2002-07-09 Mcgill University Compounds and methods for cancer therapy
US6346512B1 (en) 1996-07-12 2002-02-12 Mcgill University Compounds and methods for modulating cell adhesion
US6562786B1 (en) 1996-07-12 2003-05-13 Mcgill University Compounds and methods for modulating apoptosis
US6207639B1 (en) 1996-07-12 2001-03-27 Mcgill University Compounds and methods for modulating neurite outgrowth
US6169071B1 (en) 1996-07-12 2001-01-02 Mcgill University Compounds and methods for modulating cell adhesion
US6610821B1 (en) 1996-07-12 2003-08-26 Mcgill University Compounds and methods for modulating endothelial cell adhesion
US6551994B1 (en) 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
US6203788B1 (en) 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
US6638911B1 (en) 1998-05-05 2003-10-28 Adherex Technologies Inc. Compounds and methods for modulating desmosomal cadherin-mediated functions
US6472367B1 (en) 1998-05-05 2002-10-29 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin mediated cell adhesion
US6680175B2 (en) 1998-05-05 2004-01-20 Adherex Technologies, Inc. Methods for diagnosing and evaluating cancer
AU759144B2 (en) 1998-05-05 2003-04-03 Adherex Technologies Inc. Compounds and methods for modulating nonclassical cadherin-mediated functions
US7481999B2 (en) 1998-05-05 2009-01-27 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin-mediated function
US6465007B1 (en) 1998-07-02 2002-10-15 Genzyme Corporation Transgene expression in polarized cells
US6277824B1 (en) 1998-07-10 2001-08-21 Adherex Technologies Compounds and methods for modulating adhesion molecule function
AU4417000A (en) * 1999-04-15 2000-11-02 Glaxo Group Limited Novel pharmaceutical composition suitable for gene therapy
AU2001258659A1 (en) * 2000-05-30 2001-12-11 Ich Productions Limited Improved methods of transfection
EP1560850A2 (en) 2002-11-14 2005-08-10 Adherex Technologies, Inc. Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion
WO2006088491A2 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
CA2900876A1 (en) 2004-12-22 2006-08-17 Bhi Limited Partnership Methods and compositions for treating amyloid-related diseases
GEP20115226B (en) 2005-04-26 2011-06-10 Pfizer P-cadherin antibodies
KR101443573B1 (en) 2006-10-12 2014-11-03 비에이치아이 리미티드 파트너쉽 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
WO2010035261A2 (en) 2008-09-29 2010-04-01 Ben Gurion University Of The Negev Research And Development Authority Amyloid beta-peptides and methods of use thereof
BR112016006564B1 (en) 2013-09-24 2023-11-21 University Of Washington Through Its Center For Commercialization RECOMBINANT ADB-2/3 FIBER POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION
US20190271703A1 (en) * 2016-10-26 2019-09-05 Duke University Biomarkers and treatments for metastatic cancer
US20230137562A1 (en) 2017-06-07 2023-05-04 Adrx, Inc. Tau aggregation inhibitors
US11453701B2 (en) 2017-08-18 2022-09-27 Adrx, Inc. Tau aggregation peptide inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004663A1 (en) * 1987-11-18 1989-06-01 State Of Oregon Acting By And Through The State Bo Method for the delivery of genetic material across the blood brain barrier

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004663A1 (en) * 1987-11-18 1989-06-01 State Of Oregon Acting By And Through The State Bo Method for the delivery of genetic material across the blood brain barrier

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CELLULAR BIOLOGY (ABSTRACTS OF THE THIRTIETH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY) vol. 111, no. 5(2), December 1990, NEW YORK page 408A LIAW, C.W. ET AL 'Disruption of MDCK and bovine endothelial cell tight junctions with cadherin sinthetic peptides' *
See also references of WO9104745A1 *

Also Published As

Publication number Publication date
WO1991004745A1 (en) 1991-04-18
JPH05500504A (en) 1993-02-04
EP0494175A1 (en) 1992-07-15
CA2067183A1 (en) 1991-03-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19920327

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TOMASELLI, KEVIN, J.

Inventor name: LIAW, CHEN, W.

Inventor name: RUBIN, LEE, L. DR. C/O EISAI LONDON REASEARCH LAB

A4 Supplementary search report drawn up and despatched

Effective date: 19930315

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Effective date: 19950216