DE69430813T2 - Verwendung eines inositoltriphosphatesters zur behandlung von entzündungen - Google Patents
Verwendung eines inositoltriphosphatesters zur behandlung von entzündungenInfo
- Publication number
- DE69430813T2 DE69430813T2 DE69430813T DE69430813T DE69430813T2 DE 69430813 T2 DE69430813 T2 DE 69430813T2 DE 69430813 T DE69430813 T DE 69430813T DE 69430813 T DE69430813 T DE 69430813T DE 69430813 T2 DE69430813 T2 DE 69430813T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- damage
- tissue damage
- sec
- inflammatory conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N inositol Chemical compound OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title 1
- 235000011178 triphosphate Nutrition 0.000 title 1
- 239000001226 triphosphate Substances 0.000 title 1
- 230000006378 damage Effects 0.000 abstract 4
- 230000000451 tissue damage Effects 0.000 abstract 3
- 231100000827 tissue damage Toxicity 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000004968 inflammatory condition Effects 0.000 abstract 2
- MMWCIQZXVOZEGG-UHFFFAOYSA-N 1,4,5-IP3 Natural products OC1C(O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(O)C1OP(O)(O)=O MMWCIQZXVOZEGG-UHFFFAOYSA-N 0.000 abstract 1
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- MMWCIQZXVOZEGG-XJTPDSDZSA-N D-myo-Inositol 1,4,5-trisphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O MMWCIQZXVOZEGG-XJTPDSDZSA-N 0.000 abstract 1
- 206010015866 Extravasation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 210000002565 arteriole Anatomy 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000001736 capillary Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000036251 extravasation Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 210000000264 venule Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303854A SE503122C2 (sv) | 1993-11-22 | 1993-11-22 | Användning av en inositoltrisfosfatester för behandling av inflammatoriska tillstånd |
| PCT/SE1994/001095 WO1995014477A1 (en) | 1993-11-22 | 1994-11-18 | The use of an ester of inositoltrisphosphate for the treatment of inflammatory conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69430813D1 DE69430813D1 (de) | 2002-07-18 |
| DE69430813T2 true DE69430813T2 (de) | 2003-01-30 |
Family
ID=20391829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69430813T Expired - Fee Related DE69430813T2 (de) | 1993-11-22 | 1994-11-18 | Verwendung eines inositoltriphosphatesters zur behandlung von entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5866557A (de) |
| EP (1) | EP0730460B1 (de) |
| JP (1) | JP4172045B2 (de) |
| AT (1) | ATE218871T1 (de) |
| AU (1) | AU1081795A (de) |
| DE (1) | DE69430813T2 (de) |
| DK (1) | DK0730460T3 (de) |
| ES (1) | ES2177620T3 (de) |
| SE (1) | SE503122C2 (de) |
| WO (1) | WO1995014477A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9600194D0 (sv) * | 1996-01-19 | 1996-01-19 | Perstorp Ab | A new chemical compound |
| AU2001291173A1 (en) * | 2000-09-22 | 2002-04-02 | Orphan Medical, Inc. | Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers |
| CA2430190A1 (en) | 2000-11-21 | 2002-05-30 | Alexis Traynor-Kaplan | Inositol derivatives for increasing chloride secretion and inhibiting inflammation |
| FR2828206B1 (fr) * | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| EP1503768B1 (de) | 2002-04-29 | 2015-10-28 | NormOxys, Inc. | Inositolpyrophosphate und deren Anwendung |
| FI20021570A0 (fi) * | 2002-09-03 | 2002-09-03 | Gallen Kallela Siren Janne | Päällystetyn kirurgisen stentin paranneltu rakenne |
| US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
| US20050130897A1 (en) * | 2003-12-11 | 2005-06-16 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
| US20060258626A1 (en) * | 2004-07-06 | 2006-11-16 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| US20060106000A1 (en) * | 2004-07-06 | 2006-05-18 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| US7745423B2 (en) * | 2004-07-06 | 2010-06-29 | NormOxys, Inc | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin |
| PL1863495T3 (pl) * | 2005-03-18 | 2015-06-30 | Normoxys Inc | Sól wapniowa 1,6:2,3:4,5-tripirofosforanu mioinozytolu jako efektor allosteryczny hemoglobiny w leczeniu raka |
| CA2674048A1 (en) * | 2006-12-29 | 2008-07-10 | Normoxys, Inc. | Cyclitols and their derivatives and their therapeutic applications |
| EP2152085A4 (de) * | 2007-05-01 | 2012-05-23 | Normoxys Inc | Erythropetinkomplementierung oder -ersatz |
| US20080287341A1 (en) * | 2007-05-18 | 2008-11-20 | Danyang Chen | Treatment of vascular abnormalities using nanoparticles |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| SE465951B (sv) * | 1984-10-23 | 1991-11-25 | Perstorp Ab | Isomer av inositoltrifosfat foeretraedesvis i saltform foer anvaendning som terapeutiskt eller profylaktiskt medel samt kompositioner daerav |
| SE8605063D0 (sv) * | 1986-11-26 | 1986-11-26 | Matti Siren | Derivatives of cyclohexane |
| SE464059C (sv) * | 1988-09-15 | 1996-12-04 | Perstorp Ab | Användning av inositoltrifosfat för framställning av läkemedel |
| CA2019878A1 (en) * | 1989-09-13 | 1991-03-13 | Robert Sabin | Method of treatment of rheumatoid arthritis using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
-
1993
- 1993-11-22 SE SE9303854A patent/SE503122C2/sv not_active IP Right Cessation
-
1994
- 1994-11-18 DK DK95901676T patent/DK0730460T3/da active
- 1994-11-18 EP EP95901676A patent/EP0730460B1/de not_active Expired - Lifetime
- 1994-11-18 DE DE69430813T patent/DE69430813T2/de not_active Expired - Fee Related
- 1994-11-18 JP JP51499395A patent/JP4172045B2/ja not_active Expired - Fee Related
- 1994-11-18 WO PCT/SE1994/001095 patent/WO1995014477A1/en active IP Right Grant
- 1994-11-18 ES ES95901676T patent/ES2177620T3/es not_active Expired - Lifetime
- 1994-11-18 AU AU10817/95A patent/AU1081795A/en not_active Abandoned
- 1994-11-18 US US08/640,785 patent/US5866557A/en not_active Expired - Fee Related
- 1994-11-18 AT AT95901676T patent/ATE218871T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0730460B1 (de) | 2002-06-12 |
| ES2177620T3 (es) | 2002-12-16 |
| ATE218871T1 (de) | 2002-06-15 |
| JP4172045B2 (ja) | 2008-10-29 |
| US5866557A (en) | 1999-02-02 |
| EP0730460A1 (de) | 1996-09-11 |
| WO1995014477A1 (en) | 1995-06-01 |
| SE503122C2 (sv) | 1996-03-25 |
| SE9303854L (sv) | 1995-05-23 |
| SE9303854D0 (sv) | 1993-11-22 |
| DE69430813D1 (de) | 2002-07-18 |
| JPH09505581A (ja) | 1997-06-03 |
| DK0730460T3 (da) | 2002-09-23 |
| AU1081795A (en) | 1995-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |