DE69416245D1 - Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen - Google Patents

Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen

Info

Publication number
DE69416245D1
DE69416245D1 DE69416245T DE69416245T DE69416245D1 DE 69416245 D1 DE69416245 D1 DE 69416245D1 DE 69416245 T DE69416245 T DE 69416245T DE 69416245 T DE69416245 T DE 69416245T DE 69416245 D1 DE69416245 D1 DE 69416245D1
Authority
DE
Germany
Prior art keywords
chamber
powdered medicine
storage chamber
accomodation
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69416245T
Other languages
English (en)
Other versions
DE69416245T2 (de
Inventor
Yuji Makino
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE69416245D1 publication Critical patent/DE69416245D1/de
Publication of DE69416245T2 publication Critical patent/DE69416245T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Formation And Processing Of Food Products (AREA)
  • External Artificial Organs (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69416245T 1993-05-12 1994-05-12 Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen Expired - Fee Related DE69416245T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11041293 1993-05-12
PCT/JP1994/000771 WO1994026338A1 (en) 1993-05-12 1994-05-12 Device and method for dispensing powdered medicine in multiple doses

Publications (2)

Publication Number Publication Date
DE69416245D1 true DE69416245D1 (de) 1999-03-11
DE69416245T2 DE69416245T2 (de) 1999-07-08

Family

ID=14535130

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416245T Expired - Fee Related DE69416245T2 (de) 1993-05-12 1994-05-12 Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen

Country Status (11)

Country Link
US (1) US5634900A (de)
EP (1) EP0652022B1 (de)
JP (1) JP3132830B2 (de)
KR (1) KR100244690B1 (de)
AT (1) ATE176164T1 (de)
AU (1) AU684779B2 (de)
CA (1) CA2140021C (de)
DE (1) DE69416245T2 (de)
DK (1) DK0652022T3 (de)
FI (1) FI112919B (de)
WO (1) WO1994026338A1 (de)

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JP3308425B2 (ja) * 1995-03-10 2002-07-29 株式会社ユニシアジェックス 鼻腔用投薬器
DE19518810A1 (de) * 1995-05-26 1996-11-28 Bayer Ag Nasal-Applikator
WO1997004826A1 (fr) 1995-07-25 1997-02-13 Teijin Limited Dispositif de dosage de medicament en poudre
JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
HU221033B1 (hu) * 1996-02-21 2002-07-29 Schering Corp. Poradagoló készülék
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
SE9700938D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler II and a method of construction thereof
CN1204935C (zh) * 1999-01-14 2005-06-08 帝人株式会社 粉末药物多剂量给药器
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SE9903824D0 (sv) * 1999-10-22 1999-10-22 Medifront Ab Anordning för avgivning av multipla doser för pulverinhalatorer och motsvarande avgivningsförfarande
WO2001041850A1 (en) * 1999-12-07 2001-06-14 Orion Corporation Multidose powder inhaler
DK1291031T3 (da) * 2000-06-12 2006-10-09 Teijin Ltd Multidosis-administrationsindretning til pulverformig medicin
US6457471B1 (en) * 2000-06-30 2002-10-01 Medihale Ltd. Dual-purpose medical device for upper airway treatment and methods for using same
US20030041860A1 (en) * 2001-08-29 2003-03-06 Verona Steven N. Particulate dispenser
US6923175B2 (en) * 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
NZ531756A (en) * 2002-07-16 2007-11-30 Teijin Ltd Method and device of producing multiple doser for powdered medicine
DE10233150B4 (de) * 2002-07-22 2013-03-07 Alfred Von Schuckmann Handbetätigbarer Inhalator für pulverförmige Substanzen
FI20031158A (fi) * 2003-08-15 2005-02-16 Perlos Oyj Inhalaattori
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
EP2322180B1 (de) 2004-08-23 2015-05-27 MannKind Corporation Diketopiperazinsalze zur Arzneimitteldarreichung
JP2006087797A (ja) * 2004-09-27 2006-04-06 Hitachi Ltd 鼻腔用投薬器
US7799344B2 (en) 2005-09-14 2010-09-21 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
ES2647080T3 (es) 2006-02-22 2017-12-19 Mannkind Corporation Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo
DE102006044752A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kolbendosierer
EP2217602B1 (de) * 2007-11-30 2018-08-29 Boehringer Ingelheim International GmbH 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-on- derivative und ihre verwendung als pde9a modulatoren zur behandlung von erkrankungen des zns
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
EP2609954B1 (de) 2008-06-20 2021-12-29 MannKind Corporation Interaktives Gerät für die Echtzeit-Profilierung von Inhalationsversuchen
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
PE20110383A1 (es) 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
EP2346556B1 (de) 2008-09-26 2014-11-05 Oriel Therapeutics, Inc. Trockenpulver-inhalatoren mit doppelten einstechelementen und relevante vorrichtungen und verfahren
CA2732842C (en) * 2008-09-26 2018-01-09 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods
US8887722B2 (en) * 2008-09-26 2014-11-18 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
EP2328645B1 (de) * 2008-10-01 2015-11-11 Oriel Therapeutics, Inc. Trockenpulverinhalatoren mit rotierenden einstichmechanismen sowie entsprechende vorrichtungen und verfahren
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010112437A1 (en) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
TW201118099A (en) * 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
EP2603511B1 (de) 2010-08-12 2017-03-15 Boehringer Ingelheim International GmbH 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-on derivate und ihre verwendung als pde9a inhibitoren
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
BR122020008875B8 (pt) 2011-04-01 2022-12-06 Mannkind Corp Embalagem de bolha e método de fabricação de uma embalagem de bolhas
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
EP2872205B1 (de) 2012-07-12 2017-02-08 MannKind Corporation System zur verabreichung von arzneimitteln in trockenpulverform
US9339638B2 (en) 2012-08-08 2016-05-17 Healthpartners Research & Education Antibiotic delivery system and method
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3708933A1 (de) * 1987-03-19 1988-09-29 Heinrich Prof Dr Ing Reents Verfahren mit den dazu gehoerigen vorrichtungen zur dosierung feiner und fester werkstoff- und wirkstoffteilchen mit hilfe schwingungserzeugender systeme
IT1237118B (it) * 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
DK544589D0 (da) * 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
GB9025705D0 (en) * 1990-11-27 1991-01-09 Britains Petite Ltd Powder inhaler
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
FR2676929B1 (fr) * 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
IT1248059B (it) * 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere
US5546932A (en) * 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
ES2092727T3 (es) * 1992-06-05 1996-12-01 Hoechst Ag Inhalador.
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
KR0163472B1 (ko) * 1992-12-18 1998-11-16 에릭 에스. 딕커 분말 약품용 흡입기

Also Published As

Publication number Publication date
FI950130A0 (fi) 1995-01-11
FI112919B (fi) 2004-02-13
ATE176164T1 (de) 1999-02-15
KR950702442A (ko) 1995-07-29
EP0652022B1 (de) 1999-01-27
FI950130A (fi) 1995-03-10
JP3132830B2 (ja) 2001-02-05
EP0652022A1 (de) 1995-05-10
AU684779B2 (en) 1998-01-08
KR100244690B1 (ko) 2000-02-15
DE69416245T2 (de) 1999-07-08
CA2140021C (en) 2001-09-04
CA2140021A1 (en) 1994-11-24
US5634900A (en) 1997-06-03
WO1994026338A1 (en) 1994-11-24
AU6690694A (en) 1994-12-12
DK0652022T3 (da) 1999-09-13
EP0652022A4 (de) 1995-10-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee