DE69406523T2 - Verfahren zur Zentrifugalkonzentrierung von Makromolekülen und Vorrichtung zur Durchführung des Verfahrens - Google Patents

Verfahren zur Zentrifugalkonzentrierung von Makromolekülen und Vorrichtung zur Durchführung des Verfahrens

Info

Publication number
DE69406523T2
DE69406523T2 DE69406523T DE69406523T DE69406523T2 DE 69406523 T2 DE69406523 T2 DE 69406523T2 DE 69406523 T DE69406523 T DE 69406523T DE 69406523 T DE69406523 T DE 69406523T DE 69406523 T2 DE69406523 T2 DE 69406523T2
Authority
DE
Germany
Prior art keywords
sample
macromolecules
pct
filter
sample reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69406523T
Other languages
English (en)
Other versions
DE69406523D1 (de
Inventor
Vincenzo Vassarotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69406523D1 publication Critical patent/DE69406523D1/de
Publication of DE69406523T2 publication Critical patent/DE69406523T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16—Rotary, reciprocated or vibrated modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Centrifugal Separators (AREA)
  • Polarising Elements (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE69406523T 1993-05-21 1994-05-24 Verfahren zur Zentrifugalkonzentrierung von Makromolekülen und Vorrichtung zur Durchführung des Verfahrens Expired - Lifetime DE69406523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19939301759A SE9301759D0 (sv) 1993-05-21 1993-05-21 Centrifugal method for concentrating macromolecules from a solution and device for carrying out said method
PCT/EP1994/001701 WO1994027724A1 (en) 1993-05-21 1994-05-24 Centrifugal method for concentrating macromolecules from a solution and device for carrying out said method

Publications (2)

Publication Number Publication Date
DE69406523D1 DE69406523D1 (de) 1997-12-04
DE69406523T2 true DE69406523T2 (de) 1998-04-09

Family

ID=20390029

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69406523T Expired - Lifetime DE69406523T2 (de) 1993-05-21 1994-05-24 Verfahren zur Zentrifugalkonzentrierung von Makromolekülen und Vorrichtung zur Durchführung des Verfahrens

Country Status (7)

Country Link
US (1) US5647990A (de)
EP (1) EP0651675B1 (de)
JP (1) JP3197014B2 (de)
AT (1) ATE159668T1 (de)
DE (1) DE69406523T2 (de)
SE (1) SE9301759D0 (de)
WO (1) WO1994027724A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684893B2 (en) 2016-07-26 2023-06-27 Guangzhou Supbio Bio-Technology And Science Co., Ltd. Method for exosome separation and extraction by stacked centrifugal filtration

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US5674395A (en) * 1995-06-05 1997-10-07 Millipore Corporation Multiple sample separator
SE9604441D0 (sv) * 1996-12-02 1996-12-02 Vincenzo Vassarotti Method, device and apparatus for concentrating and/or purifying macromolecules in a solution
US5915583A (en) * 1997-05-21 1999-06-29 Abbott Laboraties Container
US6344140B1 (en) * 1997-08-11 2002-02-05 Peter Zuk, Jr. Centrifugal filtration apparatus
US6156199A (en) * 1997-08-11 2000-12-05 Zuk, Jr.; Peter Centrifugal filtration apparatus
EP1144094B1 (de) 1998-12-04 2004-03-17 Orbital Biosciences, L.L.C. Ultrafiltrations-vorrichtung und verfahren zu deren herstellung
SE9900530D0 (sv) * 1999-02-15 1999-02-15 Vincenzo Vassarotti A device for concentrating and/or purifying macromolecules in a solution and a method for manufacturing such a device
SE9904539D0 (sv) * 1999-12-10 1999-12-10 Alphahelix Ab Method and device for the handling of samples and reagents
US20020057996A1 (en) * 2000-04-10 2002-05-16 Bass Leland L. Centrifuge tube assembly
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
EP1284816B1 (de) * 2000-05-18 2009-08-05 Millipore Corporation Mehrfachlochplatte mit durch klebe verbundenem filter
US6899810B1 (en) * 2000-08-11 2005-05-31 Millipore Corporation Fluid filtering device
WO2002055673A1 (en) * 2001-01-10 2002-07-18 Biopore, Inc. Cell concentrator and washer
US6719896B1 (en) 2002-01-23 2004-04-13 Millipore Corporation Fluid-filtration receptacle with user-variable semi-permeable drain assembly
JP4391761B2 (ja) * 2003-04-28 2009-12-24 積水メディカル株式会社 血液検査用容器
US7510654B2 (en) * 2005-12-29 2009-03-31 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
US8747669B1 (en) 2005-12-29 2014-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
IL184183A0 (en) 2007-06-25 2007-10-31 Benjamin Alspector Bi directional transfer of an aliquot of fluid between compartments
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
JP2012519300A (ja) * 2009-03-02 2012-08-23 ディグニティー ヘルス 治療デバイスおよび使用方法
CN101898088B (zh) * 2009-05-25 2012-12-26 河北医科大学 一种适用于微量样品前处理的离心超滤装置
JP5330144B2 (ja) * 2009-07-31 2013-10-30 花王株式会社 微量固体試料分析器具
EP2511011A4 (de) * 2009-12-07 2014-07-09 Min-Yong Jeon Zentrifugenrohr
WO2011156734A2 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
DE202011002149U1 (de) * 2011-01-31 2011-10-26 Sartorius Stedim Biotech Gmbh Filtrationsbehälter
DE202011002150U1 (de) 2011-01-31 2011-07-20 Sartorius Stedim Biotech Gmbh Filtrationsbehälter
US9221049B2 (en) 2011-03-24 2015-12-29 Boehringer Ingelheim Microparts Gmbh Device and method for removing a supernatant of a liquid sample, and use of a valve device having a soluble membrane
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
AU2012253345B2 (en) 2011-05-12 2016-10-20 Exact Sciences Corporation Isolation of nucleic acids
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
US9539570B2 (en) * 2012-11-30 2017-01-10 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9662649B2 (en) 2013-05-06 2017-05-30 Hitachi Chemical Company America, Ltd. Devices and methods for capturing target molecules
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
JP6631852B2 (ja) 2014-11-12 2020-01-15 日立化成株式会社 臓器障害を診断するための方法および装置
KR101776245B1 (ko) 2014-11-20 2017-09-11 울산과학기술원 입자 여과 장치 및 입자 여과 방법
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
GB201617417D0 (en) * 2016-10-14 2016-11-30 M�Hlbacher Wolfgang Stirring device and method for concentrating macromolecules
PT109932A (pt) * 2017-02-24 2018-09-12 Inst Superior Tecnico Dispositivo de filtração centrífuga e método para concentração de misturas líquidas
CN110553894A (zh) * 2019-10-15 2019-12-10 杭州九龄科技有限公司 一种样品纯化浓缩装置
KR102482029B1 (ko) * 2020-08-13 2022-12-27 주식회사 움틀 멤브레인 원심분리 농축기

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US3488768A (en) * 1968-02-08 1970-01-06 Amicon Corp Self-cleaning ultrafilter
US3583627A (en) * 1969-09-04 1971-06-08 Onslow H Wilson Apparatus for the concentration of macromolecules and subcellular particles from dilute solutions
DE7636679U1 (de) * 1976-11-22 1977-03-10 Boehringer Mannheim Gmbh, 6800 Mannheim Vorrichtung zur chemischen und/oder physikalischen behandlung von fluessigkeiten
US4632761A (en) * 1983-08-15 1986-12-30 W. R. Grace & Co. Centrifugal microconcentrator and methods for its use
US4874516A (en) * 1984-12-29 1989-10-17 Ngk Insulators, Ltd. A ceramic filter for semi-ultrafiltration
US4722792A (en) * 1985-02-09 1988-02-02 Kurashiki Boseki Kabushiki Kaisha Filter for centrifugal separator
DE3621257A1 (de) * 1986-06-25 1988-01-07 Akzo Gmbh Verfahren zur herstellung poren aufweisender kohlenstoffmembranen
DE3722564A1 (de) * 1987-07-08 1989-01-19 Andreas Szabados Filtrationseinheit, insbesondere fuer medizinische proben
CA2013021C (en) * 1989-11-29 1995-05-09 Richard Lewis Columbus Blood collection device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684893B2 (en) 2016-07-26 2023-06-27 Guangzhou Supbio Bio-Technology And Science Co., Ltd. Method for exosome separation and extraction by stacked centrifugal filtration

Also Published As

Publication number Publication date
JPH08501727A (ja) 1996-02-27
EP0651675B1 (de) 1997-10-29
ATE159668T1 (de) 1997-11-15
US5647990A (en) 1997-07-15
JP3197014B2 (ja) 2001-08-13
SE9301759D0 (sv) 1993-05-21
EP0651675A1 (de) 1995-05-10
WO1994027724A1 (en) 1994-12-08
DE69406523D1 (de) 1997-12-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SARTORIUS AG, 37075 GOETTINGEN, DE

8381 Inventor (new situation)

Free format text: VASSAROTTI, VINCENZO, BUGNAUX SUR ROLLE, CH

8327 Change in the person/name/address of the patent owner

Owner name: VIVASCIENCE AG, 30625 HANNOVER, DE

8327 Change in the person/name/address of the patent owner

Owner name: SARTORIUS STEDIM BIOTECH GMBH, 37079 GOETTINGE, DE