DE69325020T2 - Calanolid antivirale verbindungen, zusammensetzungen und verwendungen davon - Google Patents

Calanolid antivirale verbindungen, zusammensetzungen und verwendungen davon

Info

Publication number
DE69325020T2
DE69325020T2 DE69325020T DE69325020T DE69325020T2 DE 69325020 T2 DE69325020 T2 DE 69325020T2 DE 69325020 T DE69325020 T DE 69325020T DE 69325020 T DE69325020 T DE 69325020T DE 69325020 T2 DE69325020 T2 DE 69325020T2
Authority
DE
Germany
Prior art keywords
compositions
calanolid
antiviral compounds
compounds
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69325020T
Other languages
English (en)
Other versions
DE69325020D1 (de
Inventor
Michael R Boyd
John H Ii Cardellina
Kirk R Gustafson
James B Mcmahon
Richard W Fuller
Gordon M Cragg
Yoel Kashman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of DE69325020D1 publication Critical patent/DE69325020D1/de
Application granted granted Critical
Publication of DE69325020T2 publication Critical patent/DE69325020T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69325020T 1992-03-31 1993-03-24 Calanolid antivirale verbindungen, zusammensetzungen und verwendungen davon Expired - Lifetime DE69325020T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86124992A 1992-03-31 1992-03-31
PCT/US1993/002810 WO1993020082A1 (en) 1992-03-31 1993-03-24 Calanolide antiviral compounds, compositions and uses thereof

Publications (2)

Publication Number Publication Date
DE69325020D1 DE69325020D1 (de) 1999-06-24
DE69325020T2 true DE69325020T2 (de) 1999-11-18

Family

ID=25335281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325020T Expired - Lifetime DE69325020T2 (de) 1992-03-31 1993-03-24 Calanolid antivirale verbindungen, zusammensetzungen und verwendungen davon

Country Status (10)

Country Link
EP (1) EP0633887B1 (de)
JP (1) JP3103114B2 (de)
AT (1) ATE180259T1 (de)
AU (1) AU671827B2 (de)
CA (1) CA2133080C (de)
DE (1) DE69325020T2 (de)
DK (1) DK0633887T3 (de)
ES (1) ES2134259T3 (de)
GR (1) GR3030852T3 (de)
WO (1) WO1993020082A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0674643A1 (de) * 1992-12-23 1995-10-04 Smithkline Beecham Corporation Cumarin-derivate als retrovirale inhibitoren
US5977385A (en) * 1994-08-03 1999-11-02 Sarawak Medichem Pharmaceuticals Method for the preparation of (+)-calanolide A and analogues thereof
US5892060A (en) * 1994-08-03 1999-04-06 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (+)-calanolide a and analogues thereof
US6277879B1 (en) 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
US6043271A (en) * 1994-08-03 2000-03-28 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (±)-calanolide A and intermediates thereof
US5608085A (en) * 1995-02-27 1997-03-04 The University Of Tennessee Research Corporation Synthesis of optically active calanolides A and B and enantiomers and related compounds
US6160131A (en) * 1997-12-19 2000-12-12 Sarawak Medichem Pharmaceuticals, Inc. Scalable method for the isolation of anti-HIV agents from the tropical plant calophyllum
ID29547A (id) * 1998-10-15 2001-09-06 Sarawak Medichem Pharmaceuticals Inc Metoda dan komposisi untuk pencegahan dan pengobatan tuberkulosis
EP1173442A2 (de) 1999-04-26 2002-01-23 Sarawak Medichem Pharmaceuticals Inc. Verfahren zur herstellung antiviraler calanolid-verbindungen
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same

Also Published As

Publication number Publication date
EP0633887B1 (de) 1999-05-19
DE69325020D1 (de) 1999-06-24
EP0633887A1 (de) 1995-01-18
JP3103114B2 (ja) 2000-10-23
DK0633887T3 (da) 1999-11-29
JPH08502948A (ja) 1996-04-02
AU671827B2 (en) 1996-09-12
ATE180259T1 (de) 1999-06-15
WO1993020082A1 (en) 1993-10-14
AU3935593A (en) 1993-11-08
CA2133080C (en) 2006-06-06
CA2133080A1 (en) 1993-10-14
ES2134259T3 (es) 1999-10-01
GR3030852T3 (en) 1999-11-30

Similar Documents

Publication Publication Date Title
GR3034279T3 (en) Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
ES2178037T3 (es) Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.
DE69632256D1 (de) Antivirale proteine, dafür kodierende dna, und deren verwendung
CA2163348A1 (en) Calanolide and Related Antiviral Compounds, Compositions, and Uses Thereof
DE69019533T2 (de) Behandlung von hiv-infizierungen und nützliche verbindungen dafür.
DE69325020D1 (de) Calanolid antivirale verbindungen, zusammensetzungen und verwendungen davon
DK284189D0 (da) Farmaceutisk produkter
ES2123156T3 (es) Compuestos y procedimientos de inhibicion de hiv y virus semejantes.
ES2103577T3 (es) Compuestos antiviricos de naftoquinona, composiciones que los contienen y utilizaciones de estos compuestos.
CA2100066A1 (en) Michellamines useful as antiviral agents, composition and method of treatment
ES2102772T3 (es) Compuesto citotoxico y antiviral.
IT1197516B (it) Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
NZ268476A (en) 14-substituted marcfortines, preparation and pharmaceutical compositions thereof
ATE185485T1 (de) Arzneimittel zur verhinderung einer infektion mit dem für aids verantwortlichen virus
RU93058386A (ru) Противовирусная комбинация, содержащая неуклеозидный аналог, фармацевтическая композиция, способ лечения
EP0392666A3 (de) Anti-HIV Zusammensetzungen
TH3782EX (th) นิวคลีโอไซด์ที่ต่อต้านไวรัส

Legal Events

Date Code Title Description
8364 No opposition during term of opposition