DE69222150D1 - Prozess zur produktion von cyclosporin-a und/oder c - Google Patents

Prozess zur produktion von cyclosporin-a und/oder c

Info

Publication number
DE69222150D1
DE69222150D1 DE69222150T DE69222150T DE69222150D1 DE 69222150 D1 DE69222150 D1 DE 69222150D1 DE 69222150 T DE69222150 T DE 69222150T DE 69222150 T DE69222150 T DE 69222150T DE 69222150 D1 DE69222150 D1 DE 69222150D1
Authority
DE
Germany
Prior art keywords
cyclosporin
production
medium
nectria
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222150T
Other languages
English (en)
Other versions
DE69222150T2 (de
Inventor
Toshio - - Goto
Tohru - Kino
Masakuni - Okuhara
Hirokazu - Tanaka
Yasuhisa - - - Tsurumi
Shigehiro - Takase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69222150D1 publication Critical patent/DE69222150D1/de
Application granted granted Critical
Publication of DE69222150T2 publication Critical patent/DE69222150T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69222150T 1991-01-25 1992-01-22 Prozess zur produktion von cyclosporin-a und/oder c Expired - Fee Related DE69222150T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8715191 1991-01-25
PCT/JP1992/000047 WO1992013094A1 (fr) 1991-01-25 1992-01-22 Procede pour produire de la cyclosporine a et/ou c

Publications (2)

Publication Number Publication Date
DE69222150D1 true DE69222150D1 (de) 1997-10-16
DE69222150T2 DE69222150T2 (de) 1998-01-15

Family

ID=13906982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222150T Expired - Fee Related DE69222150T2 (de) 1991-01-25 1992-01-22 Prozess zur produktion von cyclosporin-a und/oder c

Country Status (8)

Country Link
US (1) US5447854A (de)
EP (1) EP0568698B1 (de)
JP (1) JP3099365B2 (de)
AT (1) ATE158022T1 (de)
AU (1) AU660651B2 (de)
CA (1) CA2101777A1 (de)
DE (1) DE69222150T2 (de)
WO (1) WO1992013094A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
EP0725076B1 (de) * 1995-02-01 2001-06-06 National Research Development Corporation of India Verfahren zur Gewinnung von Cyclosporin A aus einer Tolypocladiumspecies
DE19611094C2 (de) 1996-03-21 1999-06-17 Dresden Arzneimittel Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2463138C2 (de) * 1973-12-06 1984-07-05 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FR2393535A1 (fr) * 1977-06-07 1979-01-05 Agronomique Inst Nat Rech Procede pour l'obtention de proteines alimentaires d'origine fongique ou a partir de micro-organismes pluricellulaires, dispositif de fermentation et proteines obtenues
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use
JPS5763093A (en) * 1980-10-03 1982-04-16 Mitsubishi Chem Ind Ltd Production of cyclosporin
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.

Also Published As

Publication number Publication date
AU1181292A (en) 1992-08-27
AU660651B2 (en) 1995-07-06
EP0568698B1 (de) 1997-09-10
EP0568698A4 (de) 1994-11-23
CA2101777A1 (en) 1992-07-26
US5447854A (en) 1995-09-05
WO1992013094A1 (fr) 1992-08-06
EP0568698A1 (de) 1993-11-10
ATE158022T1 (de) 1997-09-15
JP3099365B2 (ja) 2000-10-16
DE69222150T2 (de) 1998-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee