DE69217104D1 - Oligosaccharid mit einer Affinität für den Fibroblastwachstumsfaktor und Verfahren zu dessen Herstellung - Google Patents

Oligosaccharid mit einer Affinität für den Fibroblastwachstumsfaktor und Verfahren zu dessen Herstellung

Info

Publication number
DE69217104D1
DE69217104D1 DE69217104T DE69217104T DE69217104D1 DE 69217104 D1 DE69217104 D1 DE 69217104D1 DE 69217104 T DE69217104 T DE 69217104T DE 69217104 T DE69217104 T DE 69217104T DE 69217104 D1 DE69217104 D1 DE 69217104D1
Authority
DE
Germany
Prior art keywords
oligosaccharide
affinity
growth factor
fibroblast growth
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69217104T
Other languages
English (en)
Other versions
DE69217104T2 (de
Inventor
Hiroko Habuchi
Sakaru Suzuki
Koji Kimata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Corp filed Critical Seikagaku Corp
Publication of DE69217104D1 publication Critical patent/DE69217104D1/de
Application granted granted Critical
Publication of DE69217104T2 publication Critical patent/DE69217104T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69217104T 1991-04-16 1992-04-16 Oligosaccharid mit einer Affinität für den Fibroblastwachstumsfaktor und Verfahren zu dessen Herstellung Expired - Fee Related DE69217104T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11090591 1991-04-16

Publications (2)

Publication Number Publication Date
DE69217104D1 true DE69217104D1 (de) 1997-03-13
DE69217104T2 DE69217104T2 (de) 1997-06-05

Family

ID=14547637

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217104T Expired - Fee Related DE69217104T2 (de) 1991-04-16 1992-04-16 Oligosaccharid mit einer Affinität für den Fibroblastwachstumsfaktor und Verfahren zu dessen Herstellung

Country Status (11)

Country Link
US (1) US5849722A (de)
EP (1) EP0509517B1 (de)
KR (1) KR920019810A (de)
AT (1) ATE148470T1 (de)
AU (1) AU656953B2 (de)
CA (1) CA2066305A1 (de)
DE (1) DE69217104T2 (de)
FI (1) FI921689A (de)
MX (1) MX9201801A (de)
NO (1) NO921495L (de)
ZA (1) ZA922830B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
WO1996001278A1 (fr) * 1994-07-01 1996-01-18 Seikagaku Corporation Procede pour produire un polysaccharide desulfate et une heparine desulfatee
GB9722604D0 (en) * 1997-10-28 1997-12-24 Cancer Res Campaign Tech Heparin-binding growth factor derivatives
US6812221B2 (en) * 2000-11-21 2004-11-02 The Texas A&M University System FGF-affinity chromatography
WO2002076475A2 (en) * 2001-03-23 2002-10-03 Bioparken As Glycosaminoglycan anticoagulants derived from fish
CH696701A5 (de) * 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
CN104334714A (zh) * 2012-03-30 2015-02-04 味之素株式会社 含硫酸化化合物的干细胞增殖用培养基
CN105408361B (zh) 2013-05-16 2019-09-06 新加坡科技研究局 硫酸乙酰肝素
EP3220922B1 (de) 2014-11-19 2020-10-14 Agency For Science, Technology And Research Heparansulfate zur verwendung in der reparatur und/oder regeneration der haut
WO2016080915A1 (en) 2014-11-19 2016-05-26 Agency For Science, Technology And Research Cosmetic use of heparan sulphate
CN104530262B (zh) * 2015-01-26 2016-08-24 安徽科宝生物工程有限公司 一种从猪肺中提取肝素的生产方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
FR2597484B1 (fr) * 1986-04-17 1988-12-23 Sanofi Sa Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques.
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
US5100668A (en) * 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
JPH0240399A (ja) * 1988-07-27 1990-02-09 Takeda Chem Ind Ltd 線維芽細胞増殖因子ムテインの複合体あるいは組成物
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
PT93847A (pt) * 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same

Also Published As

Publication number Publication date
ATE148470T1 (de) 1997-02-15
KR920019810A (ko) 1992-11-20
FI921689A0 (fi) 1992-04-15
US5849722A (en) 1998-12-15
NO921495D0 (no) 1992-04-15
MX9201801A (es) 1992-10-30
ZA922830B (en) 1993-01-27
FI921689A (fi) 1992-10-17
CA2066305A1 (en) 1992-10-17
NO921495L (no) 1992-10-19
EP0509517A3 (en) 1993-09-01
AU1500392A (en) 1993-03-11
AU656953B2 (en) 1995-02-23
EP0509517A2 (de) 1992-10-21
DE69217104T2 (de) 1997-06-05
EP0509517B1 (de) 1997-01-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee