DE69215360D1 - Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika - Google Patents

Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika

Info

Publication number
DE69215360D1
DE69215360D1 DE69215360T DE69215360T DE69215360D1 DE 69215360 D1 DE69215360 D1 DE 69215360D1 DE 69215360 T DE69215360 T DE 69215360T DE 69215360 T DE69215360 T DE 69215360T DE 69215360 D1 DE69215360 D1 DE 69215360D1
Authority
DE
Germany
Prior art keywords
polymilic
acid
containing antibiotics
bioresorbable implant
implant composed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69215360T
Other languages
English (en)
Other versions
DE69215360T2 (de
Inventor
Michel Vert
Jacques Mauduit
Niels Bukh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69215360D1 publication Critical patent/DE69215360D1/de
Application granted granted Critical
Publication of DE69215360T2 publication Critical patent/DE69215360T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69215360T 1991-03-14 1992-03-13 Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika Expired - Lifetime DE69215360T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9103110A FR2673843B1 (fr) 1991-03-14 1991-03-14 Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
PCT/FR1992/000231 WO1992016193A1 (fr) 1991-03-14 1992-03-13 Implant bioresorbable a base d'acide polylactique contenant un antibiotique

Publications (2)

Publication Number Publication Date
DE69215360D1 true DE69215360D1 (de) 1997-01-02
DE69215360T2 DE69215360T2 (de) 1997-06-12

Family

ID=9410735

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69215360T Expired - Lifetime DE69215360T2 (de) 1991-03-14 1992-03-13 Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika

Country Status (5)

Country Link
US (1) US5567431A (de)
EP (1) EP0575502B1 (de)
DE (1) DE69215360T2 (de)
FR (1) FR2673843B1 (de)
WO (1) WO1992016193A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692147B1 (fr) * 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
RU2143889C1 (ru) * 1993-02-23 2000-01-10 Генентек, Инк. Способ стабилизации полипептида, способы получения композиций полипептида и композиции
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
AU738034B2 (en) * 1995-03-30 2001-09-06 Advanced Cardiovascular Systems Inc. Method of incorporating drugs into a polymer component of stents
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
WO1998015263A2 (en) * 1996-10-09 1998-04-16 Takeda Chemical Industries, Ltd. A method for producing a microparticle
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5980928A (en) * 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6165195A (en) 1997-08-13 2000-12-26 Advanced Cardiovascylar Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6361544B1 (en) 1997-08-13 2002-03-26 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6117117A (en) 1998-08-24 2000-09-12 Advanced Cardiovascular Systems, Inc. Bifurcated catheter assembly
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US6383213B2 (en) 1999-10-05 2002-05-07 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6387120B2 (en) 1999-12-09 2002-05-14 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6702849B1 (en) 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
US6582394B1 (en) 2000-11-14 2003-06-24 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcated vessels
US6749628B1 (en) 2001-05-17 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
FR2840193B1 (fr) * 2002-05-31 2005-02-11 Textile Hi Tec Anneau gastrique
US8501215B2 (en) 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
US7090694B1 (en) 2003-11-19 2006-08-15 Advanced Cardiovascular Systems, Inc. Portal design for stent for treating bifurcated vessels
DE102004049121B4 (de) * 2004-10-07 2008-01-10 Heraeus Kulzer Gmbh Antibiotikum-/Antibiotika enthaltender PMMA-Knochenzement
US20070110792A9 (en) * 2005-01-03 2007-05-17 L'oreal Cosmetic or dermatological article comprising a medium that is soluble in water
FR2880262B1 (fr) * 2005-01-03 2013-11-08 Oreal Article cosmetique ou dermatologique comportant un support soluble dans l'eau
WO2007020430A2 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc Multimodal high strength devices and composites
EP3566742A1 (de) 2005-10-13 2019-11-13 Synthes GmbH Wirkstoffimprägnierte hülle
DE102005061290B4 (de) * 2005-12-20 2021-03-18 Heraeus Medical Gmbh Verfahren zur Herstellung von Antibiotikum-/Antibiotika-Partikeln und deren Verwendung
US8029558B2 (en) 2006-07-07 2011-10-04 Abbott Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US8882826B2 (en) 2006-08-22 2014-11-11 Abbott Cardiovascular Systems Inc. Intravascular stent
US8834554B2 (en) 2006-08-22 2014-09-16 Abbott Cardiovascular Systems Inc. Intravascular stent
AU2007297697A1 (en) 2006-09-20 2008-03-27 Monosol Rx Llc Edible water-soluble film containing a foam reducing flavoring agent
EP2142353A1 (de) * 2007-04-18 2010-01-13 Smith & Nephew PLC Expansionsformen von formgedächtnis-polymeren
WO2008130954A2 (en) * 2007-04-19 2008-10-30 Smith & Nephew, Inc. Graft fixation
US9000066B2 (en) * 2007-04-19 2015-04-07 Smith & Nephew, Inc. Multi-modal shape memory polymers
FR2916635B1 (fr) * 2007-05-30 2009-08-07 Backert Marie Elisabeth Cuine Formulations solides pour l'administration, par voie parente parenterale, d'acti(s),sous forme d'un film destine a etre dissout et/ou disperse dans un produit liquide
US20090112259A1 (en) * 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
EP3533399A3 (de) 2008-02-21 2019-10-23 Ethicon LLC Verfahren zum anheben von halterungen an selbsthaltenden nähten
CN105688276A (zh) 2008-02-29 2016-06-22 史密夫和内修有限公司 用于生物医学应用的梯度涂层
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
WO2011156711A1 (en) 2010-06-10 2011-12-15 Schobel Alexander M Nanoparticle film delivery systems
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
TWI590843B (zh) * 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
AU2014281010B2 (en) 2013-06-21 2018-05-10 DePuy Synthes Products, Inc. Films and methods of manufacture
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4326524A (en) * 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
GB2091554B (en) * 1981-01-13 1984-09-12 Mitsui Toatsu Chemicals Rod like moulded drug
GB8333053D0 (en) * 1983-12-12 1984-01-18 Lilly Industries Ltd Pharmaceutical and veterinary formulations
CA1311686C (en) * 1986-06-25 1992-12-22 John Weldon Shell Controlled release bioerodible drug delivery system
US4719246A (en) * 1986-12-22 1988-01-12 E. I. Du Pont De Nemours And Company Polylactide compositions
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
ATE105177T1 (de) * 1988-12-22 1994-05-15 American Cyanamid Co Verfahren zur behandlung von periodontitis durch protrahierte wirkstoffabgabe von arzneimitteln in der zahnhoehle, zusammensetzung davon und vorrichtung zur verabreichung.
EP0476045B1 (de) * 1989-06-05 1996-08-28 Massachusetts Institute Of Technology Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Also Published As

Publication number Publication date
EP0575502A1 (de) 1993-12-29
US5567431A (en) 1996-10-22
WO1992016193A1 (fr) 1992-10-01
FR2673843B1 (fr) 1995-01-13
FR2673843A1 (fr) 1992-09-18
DE69215360T2 (de) 1997-06-12
EP0575502B1 (de) 1996-11-20

Similar Documents

Publication Publication Date Title
DE69215360T2 (de) Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika
DE69233474D1 (de) Pharmazeutische Zusammensetzung enthaltend S-Nitrosoimmunoglobuline und Verwendung davon
GB9118670D0 (en) Surgical devices and uses thereof
DE69118505T2 (de) Knochenbildende Zusammensetzung und ein diese enthaltendes Implantat
DE59306001D1 (de) Wirbelsäulenimplantat und Repositionsinstrument
DE59207032D1 (de) Wirbelkörperimplantat
BR1100824A (pt) Composto e composição farmacêutica
BR9203761A (pt) Artigo absorvente e metodo de se fazer o mesmo
FI960848A (fi) Bakteereita vastustavat ja kasvustoa estävät oksatiatsiinit ja niiden oksidit
EP0497204A3 (en) Medical member and method of manufacturing the same
DE59310276D1 (de) Verwendung von Polyasparaginsäure und ihrer Salze
NO922291D0 (no) 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater
AP9200426A0 (en) Substance or composition and uses thereof
DE69223266D1 (de) Peptidderivate und deren Verwendung
DE69223984T2 (de) Zusammensetzungen von difluormethan und tetrafluorethan
HU9202085D0 (en) Derivatives of 7-isoindolinyl-quinolone and of naphthyridone-carboxylic acid
BR9200058A (pt) Composto e composicao farmaceutica
BR9205719A (pt) Preparaçao de filamentos delgados de polièster
PT87554A (pt) Didinfecting and sterilizing composition
KR950701924A (ko) 신규한 생물학적으로 활성인 에부르나메닌 유도체 및 그 유도체가 함유된 약제학적 조성물과 그 제조방법
BR9306359A (pt) Azocorantes aplicação do azocorante e modificação cristalina
HK48295A (en) Antimicrobial composition and method of use
ATA81591A (de) Wirbelkoerperimplantat
DE69208096D1 (de) Herstellung von dialkyltellur und dialkylselen
DE69126047T2 (de) Schaltkreis zur Serialisierung und Deserialisierung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition