DE69215360D1 - Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika - Google Patents

Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika

Info

Publication number
DE69215360D1
DE69215360D1 DE69215360T DE69215360T DE69215360D1 DE 69215360 D1 DE69215360 D1 DE 69215360D1 DE 69215360 T DE69215360 T DE 69215360T DE 69215360 T DE69215360 T DE 69215360T DE 69215360 D1 DE69215360 D1 DE 69215360D1
Authority
DE
Germany
Prior art keywords
polymilic
acid
containing antibiotics
bioresorbable implant
implant composed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69215360T
Other languages
English (en)
Other versions
DE69215360T2 (de
Inventor
Michel Vert
Jacques Mauduit
Niels Bukh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69215360D1 publication Critical patent/DE69215360D1/de
Application granted granted Critical
Publication of DE69215360T2 publication Critical patent/DE69215360T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69215360T 1991-03-14 1992-03-13 Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika Expired - Lifetime DE69215360T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9103110A FR2673843B1 (fr) 1991-03-14 1991-03-14 Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
PCT/FR1992/000231 WO1992016193A1 (fr) 1991-03-14 1992-03-13 Implant bioresorbable a base d'acide polylactique contenant un antibiotique

Publications (2)

Publication Number Publication Date
DE69215360D1 true DE69215360D1 (de) 1997-01-02
DE69215360T2 DE69215360T2 (de) 1997-06-12

Family

ID=9410735

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69215360T Expired - Lifetime DE69215360T2 (de) 1991-03-14 1992-03-13 Bioresorbierbares implantat bestehend aus polymilchsäure und enthaltend antibiotika

Country Status (5)

Country Link
US (1) US5567431A (de)
EP (1) EP0575502B1 (de)
DE (1) DE69215360T2 (de)
FR (1) FR2673843B1 (de)
WO (1) WO1992016193A1 (de)

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US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5980928A (en) * 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
US6361544B1 (en) 1997-08-13 2002-03-26 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6165195A (en) 1997-08-13 2000-12-26 Advanced Cardiovascylar Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6117117A (en) 1998-08-24 2000-09-12 Advanced Cardiovascular Systems, Inc. Bifurcated catheter assembly
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US6383213B2 (en) 1999-10-05 2002-05-07 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6387120B2 (en) 1999-12-09 2002-05-14 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6702849B1 (en) 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
US6582394B1 (en) 2000-11-14 2003-06-24 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcated vessels
US6749628B1 (en) 2001-05-17 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
FR2840193B1 (fr) * 2002-05-31 2005-02-11 Textile Hi Tec Anneau gastrique
US8501215B2 (en) * 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
US7090694B1 (en) 2003-11-19 2006-08-15 Advanced Cardiovascular Systems, Inc. Portal design for stent for treating bifurcated vessels
DE102004049121B4 (de) * 2004-10-07 2008-01-10 Heraeus Kulzer Gmbh Antibiotikum-/Antibiotika enthaltender PMMA-Knochenzement
US20070110792A9 (en) * 2005-01-03 2007-05-17 L'oreal Cosmetic or dermatological article comprising a medium that is soluble in water
FR2880262B1 (fr) * 2005-01-03 2013-11-08 Oreal Article cosmetique ou dermatologique comportant un support soluble dans l'eau
CA2619552A1 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc Multimodal high strength devices and composites
AU2006304229A1 (en) 2005-10-13 2007-04-26 Synthes Gmbh Drug-impregnated encasement
DE102005061290B4 (de) * 2005-12-20 2021-03-18 Heraeus Medical Gmbh Verfahren zur Herstellung von Antibiotikum-/Antibiotika-Partikeln und deren Verwendung
US8029558B2 (en) 2006-07-07 2011-10-04 Abbott Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US8834554B2 (en) 2006-08-22 2014-09-16 Abbott Cardiovascular Systems Inc. Intravascular stent
US8882826B2 (en) 2006-08-22 2014-11-11 Abbott Cardiovascular Systems Inc. Intravascular stent
JP4739452B2 (ja) 2006-09-20 2011-08-03 モノソル アールエックス リミテッド ライアビリティ カンパニー 発泡を減じる風味付与剤を含む喫食可能な水溶性フィルム
EP2142353A1 (de) * 2007-04-18 2010-01-13 Smith & Nephew PLC Expansionsformen von formgedächtnis-polymeren
JP5680957B2 (ja) * 2007-04-19 2015-03-04 スミス アンド ネフュー インコーポレーテッドＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ，Ｉｎｃ． グラフト固定
ATE547129T1 (de) 2007-04-19 2012-03-15 Smith & Nephew Inc Multimodale formgedächtnis-polymere
FR2916635B1 (fr) * 2007-05-30 2009-08-07 Backert Marie Elisabeth Cuine Formulations solides pour l'administration, par voie parente parenterale, d'acti(s),sous forme d'un film destine a etre dissout et/ou disperse dans un produit liquide
US20090112259A1 (en) * 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
EP3533399A3 (de) 2008-02-21 2019-10-23 Ethicon LLC Verfahren zum anheben von halterungen an selbsthaltenden nähten
US9011965B2 (en) 2008-02-29 2015-04-21 Smith & Nephew, Inc. Gradient coating for biomedical applications
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
JP5819949B2 (ja) 2010-06-10 2015-11-24 ミダテック リミテッド ナノ粒子フィルム送達システム
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
CA2916249C (en) 2013-06-21 2021-07-13 DePuy Synthes Products, Inc. Films and methods of manufacture
JP7653218B2 (ja) 2016-05-05 2025-03-28 アクエスティブ セラピューティクス インコーポレイテッド 送達増強エピネフリン組成物
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment

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US4326524A (en) * 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
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GB8333053D0 (en) * 1983-12-12 1984-01-18 Lilly Industries Ltd Pharmaceutical and veterinary formulations
CA1311686C (en) * 1986-06-25 1992-12-22 John Weldon Shell Controlled release bioerodible drug delivery system
US4719246A (en) * 1986-12-22 1988-01-12 E. I. Du Pont De Nemours And Company Polylactide compositions
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
ATE105177T1 (de) * 1988-12-22 1994-05-15 American Cyanamid Co Verfahren zur behandlung von periodontitis durch protrahierte wirkstoffabgabe von arzneimitteln in der zahnhoehle, zusammensetzung davon und vorrichtung zur verabreichung.
ATE141804T1 (de) * 1989-06-05 1996-09-15 Massachusetts Inst Technology Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Also Published As

Publication number Publication date
FR2673843A1 (fr) 1992-09-18
WO1992016193A1 (fr) 1992-10-01
EP0575502B1 (de) 1996-11-20
EP0575502A1 (de) 1993-12-29
US5567431A (en) 1996-10-22
DE69215360T2 (de) 1997-06-12
FR2673843B1 (fr) 1995-01-13

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Legal Events

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8364 No opposition during term of opposition