DE69213401D1 - Polymerharz für Peptidsynthese - Google Patents

Polymerharz für Peptidsynthese

Info

Publication number
DE69213401D1
DE69213401D1 DE69213401T DE69213401T DE69213401D1 DE 69213401 D1 DE69213401 D1 DE 69213401D1 DE 69213401 T DE69213401 T DE 69213401T DE 69213401 T DE69213401 T DE 69213401T DE 69213401 D1 DE69213401 D1 DE 69213401D1
Authority
DE
Germany
Prior art keywords
polymer resin
peptide synthesis
peptide
synthesis
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69213401T
Other languages
English (en)
Other versions
DE69213401T2 (de
Inventor
Robert Webber
Mohandas Pai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research and Diagnostic Antibodies
Original Assignee
Research and Diagnostic Antibodies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research and Diagnostic Antibodies filed Critical Research and Diagnostic Antibodies
Publication of DE69213401D1 publication Critical patent/DE69213401D1/de
Application granted granted Critical
Publication of DE69213401T2 publication Critical patent/DE69213401T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/14—Esterification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69213401T 1991-06-14 1992-06-09 Polymerharz für Peptidsynthese Expired - Fee Related DE69213401T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/715,561 US5198531A (en) 1991-06-14 1991-06-14 Polymeric resin for peptide synthesis
PCT/US1992/005046 WO1992022591A1 (en) 1991-06-14 1992-06-09 Polymeric resin for peptide synthesis

Publications (2)

Publication Number Publication Date
DE69213401D1 true DE69213401D1 (de) 1996-10-10
DE69213401T2 DE69213401T2 (de) 1997-02-27

Family

ID=24874558

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69213401T Expired - Fee Related DE69213401T2 (de) 1991-06-14 1992-06-09 Polymerharz für Peptidsynthese

Country Status (6)

Country Link
US (2) US5198531A (de)
EP (1) EP0543986B1 (de)
JP (1) JP2722392B2 (de)
AU (1) AU2238992A (de)
DE (1) DE69213401T2 (de)
WO (1) WO1992022591A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
FR2742157B1 (fr) * 1995-12-11 1998-01-16 Elf Aquitaine Nouveau mode de preparation de resines a fonction guanidine et obtention de nouvelles resines a fonction guanidine
US5798035A (en) 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
CA2270132A1 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
CA2268740C (en) 1996-11-06 2010-07-20 Sequenom, Inc. High density immobilization of nucleic acids
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
GB9727126D0 (en) * 1997-12-22 1998-02-25 Zeneca Ltd Process
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6124484A (en) * 1998-07-17 2000-09-26 Isis Pharmaceuticals, Inc. Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
WO2000026262A2 (en) * 1998-11-05 2000-05-11 Mitokor Functionalized polymeric substrates for binding molecular moieties
WO2000069457A1 (en) 1999-05-15 2000-11-23 University Of California, San Diego Protein a based binding domains with desirable activities
US7163686B1 (en) 1999-05-15 2007-01-16 The Regents Of The University Of California Protein A based binding domains with desirable activities
AU2001278424A1 (en) * 2000-05-12 2001-11-20 Lonza A.G. Method for producing polymer-bonded 2-chlorotrityl chloride
US7427260B2 (en) * 2001-03-30 2008-09-23 Mayo Foundation For Medical Education And Research Efficient methods for solid phase synthesis using trityl chloride resins
US6787635B2 (en) * 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
WO2002083606A1 (en) * 2001-04-17 2002-10-24 University Of Alberta A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
KR100718431B1 (ko) * 2001-11-27 2007-05-14 주식회사 유앤비케미칼 트리틸기가 도입된 폴리스티렌 수지의 제조 방법
US7049394B2 (en) * 2002-08-19 2006-05-23 Rohm And Haas Company Method for preparing free flow resin
TWI249540B (en) * 2002-08-19 2006-02-21 Rohm & Haas Resin functionalization method
US20040063856A1 (en) * 2002-09-30 2004-04-01 Bohling James Charles Resin for solid phase synthesis
JP3955257B2 (ja) * 2002-12-17 2007-08-08 独立行政法人科学技術振興機構 高分子固定ホルムアミドとその触媒並びにアリル化反応方法
CA2506533C (en) * 2002-12-20 2009-05-26 F. Hoffmann-La Roche Ag Process for the recycling of solid phase bonded ctc-resin
US20040158037A1 (en) * 2003-02-12 2004-08-12 Bohling James Charles Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
WO2005063799A2 (en) * 2003-12-31 2005-07-14 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
EP2299267A3 (de) 2005-11-16 2011-05-04 Novartis AG Biomarker zur Anti-NogoA-antikörperbehandlung bei Rückenmarksverletzung
GR1005656B (el) * 2006-06-27 2007-09-20 Βιομεντικα Λαιφ Σαιενσις Ανωνυμη Εταιρια Φαρμακευτικων Προιοντων Πολυμερης τριτυλο-τυπου ρητινη για πεπτιδικη συνθεση σε στερεα φαση
PL2152663T3 (pl) 2007-06-04 2014-09-30 Ben Gurion Univ Of The Negev Research And Development Authority Związki triarylowe oraz kompozycje zawierające te związki
US8815807B2 (en) 2008-06-03 2014-08-26 President And Fellows Of Harvard College Peptides and peptide compositions having osteoinductive activity
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
SG186552A1 (en) 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
CN106061940A (zh) 2013-11-05 2016-10-26 本古里安大学内盖夫研究发展局 治疗糖尿病和由其引发的并发疾病的化合物
DE102016009766A1 (de) * 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Herstellung von Bitterstoffderivaten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645996A (en) * 1969-03-10 1972-02-29 Lilly Co Eli Resins useful in peptide synthesis
US3743628A (en) * 1970-10-16 1973-07-03 Squibb & Sons Inc Solid phase synthesis of peptides
US3814732A (en) * 1971-10-21 1974-06-04 Hoffmann La Roche Modified solid supports for solid phase synthesis
US3954709A (en) * 1973-05-29 1976-05-04 The Regents Of The University Of Colorado Phenylethyl group containing resins for the synthesis of peptides
IL44168A (en) * 1974-02-08 1980-03-31 Yeda Res & Dev Acyl amino acylamino or oxime activated phenalkyl (or heteroacylalkyl) benzenes optionally linked to a polymer backbone as reagents useful in organic synthesis as ion exchange agents for the capture of aldehydes or for extracting metals and process for their preparation
JPS55137106A (en) * 1979-04-14 1980-10-25 Cosmo Co Ltd Lactone group-containing hydroxystyrene polymer and production thereof
SE457797B (sv) * 1982-01-13 1989-01-30 Kureha Chemical Ind Co Ltd Foerfarande foer framstaellning av poroest substrat innefattande paerlor som har metylolgrupper av sampolymer paa basis av tvaerbunden styren och anvaendni ng av substratet vid vaetskekromatografi
US4831084A (en) * 1987-05-18 1989-05-16 Bachem Feinchemikalien A.G. Resin-linker combination for the solid-phase synthesis of peptides and intermediates

Also Published As

Publication number Publication date
US5563220A (en) 1996-10-08
DE69213401T2 (de) 1997-02-27
JPH06502679A (ja) 1994-03-24
EP0543986B1 (de) 1996-09-04
US5198531A (en) 1993-03-30
AU2238992A (en) 1993-01-12
EP0543986A4 (en) 1993-11-10
JP2722392B2 (ja) 1998-03-04
WO1992022591A1 (en) 1992-12-23
EP0543986A1 (de) 1993-06-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee