DE69211755T2 - Verfahren und Vorrichtung zur Schnittstellenbildung zwischen Flüssigchromatographie oder superkritischer Chromatographie und einem Massenspektrometer (LC-SFC/MS) - Google Patents

Verfahren und Vorrichtung zur Schnittstellenbildung zwischen Flüssigchromatographie oder superkritischer Chromatographie und einem Massenspektrometer (LC-SFC/MS)

Info

Publication number
DE69211755T2
DE69211755T2 DE69211755T DE69211755T DE69211755T2 DE 69211755 T2 DE69211755 T2 DE 69211755T2 DE 69211755 T DE69211755 T DE 69211755T DE 69211755 T DE69211755 T DE 69211755T DE 69211755 T2 DE69211755 T2 DE 69211755T2
Authority
DE
Germany
Prior art keywords
chromatography
sfc
mass spectrometer
supercritical
liquid chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69211755T
Other languages
English (en)
Other versions
DE69211755D1 (de
Inventor
Gunnar Stenhagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Instruments SpA
Original Assignee
Fisons Instruments SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Instruments SpA filed Critical Fisons Instruments SpA
Publication of DE69211755D1 publication Critical patent/DE69211755D1/de
Application granted granted Critical
Publication of DE69211755T2 publication Critical patent/DE69211755T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
DE69211755T 1991-04-24 1992-04-15 Verfahren und Vorrichtung zur Schnittstellenbildung zwischen Flüssigchromatographie oder superkritischer Chromatographie und einem Massenspektrometer (LC-SFC/MS) Expired - Fee Related DE69211755T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911139A IT1247521B (it) 1991-04-24 1991-04-24 Metodo e dispositivo per interfacciare uno spettometro di massa

Publications (2)

Publication Number Publication Date
DE69211755D1 DE69211755D1 (de) 1996-08-01
DE69211755T2 true DE69211755T2 (de) 1997-01-23

Family

ID=11359778

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69211755T Expired - Fee Related DE69211755T2 (de) 1991-04-24 1992-04-15 Verfahren und Vorrichtung zur Schnittstellenbildung zwischen Flüssigchromatographie oder superkritischer Chromatographie und einem Massenspektrometer (LC-SFC/MS)

Country Status (4)

Country Link
US (1) US5376789A (de)
EP (1) EP0510510B1 (de)
DE (1) DE69211755T2 (de)
IT (1) IT1247521B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147347A (en) 1994-03-15 2000-11-14 Hitachi, Ltd. Ion source and mass spectrometer instrument using the same
IT1270203B (it) * 1994-06-09 1997-04-29 Fisons Instr Spa Procedimento e dispositivo per l'introduzione di liquidi in spettrometri di massa mediante nebulizzazione elettrostatica
US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
JP3353561B2 (ja) * 1995-09-07 2002-12-03 株式会社日立製作所 溶液の質量分析に関する方法と装置
US5756995A (en) * 1997-07-09 1998-05-26 The United States Of America As Represented By The Secretary Of The Army Ion interface for mass spectrometer
US6902937B2 (en) 2001-07-13 2005-06-07 Air Liquide America, L.P. Method for the determination of low-concentration anions in the presence of an excess of another anion
DE102004054620A1 (de) * 2004-11-11 2006-06-08 Henkel Kgaa Geranonitril-Substitut
JP6352047B2 (ja) * 2014-05-13 2018-07-04 株式会社島津製作所 異なる極性をもつ化合物を含む試料の一斉分析方法
CN105304452B (zh) * 2015-10-23 2017-10-27 浙江好创生物技术有限公司 激光电喷雾离子源
GB2567793B (en) 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
CN108828118B (zh) * 2018-03-05 2020-04-17 杭州师范大学钱江学院 一种纳流色谱分离和等离子体质谱检测的联用系统
WO2019200388A1 (en) * 2018-04-13 2019-10-17 Waters Technologies Corporation Mass spectrometer ion source with integrated column

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4641541A (en) * 1986-02-11 1987-02-10 Daryl Sharp Internal mass spectrometer interface to a gas chromatograph
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
JP2834136B2 (ja) * 1988-04-27 1998-12-09 株式会社日立製作所 質量分析計
US5130538A (en) * 1989-05-19 1992-07-14 John B. Fenn Method of producing multiply charged ions and for determining molecular weights of molecules by use of the multiply charged ions of molecules
US4999493A (en) * 1990-04-24 1991-03-12 Vestec Corporation Electrospray ionization interface and method for mass spectrometry
US5170053A (en) * 1990-08-30 1992-12-08 Finnigan Corporation Electrospray ion source and interface apparatus and method
JP2598566B2 (ja) * 1990-10-26 1997-04-09 株式会社日立製作所 質量分析計
US5164593A (en) * 1991-02-28 1992-11-17 Kratos Analytical Limited Mass spectrometer system including an ion source operable under high pressure conditions, and a two-stage pumping arrangement

Also Published As

Publication number Publication date
US5376789A (en) 1994-12-27
IT1247521B (it) 1994-12-17
DE69211755D1 (de) 1996-08-01
EP0510510B1 (de) 1996-06-26
ITMI911139A0 (it) 1991-04-24
EP0510510A3 (en) 1993-01-20
ITMI911139A1 (it) 1992-10-24
EP0510510A2 (de) 1992-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee