DE69133068D1 - Tumor-zerstörende effekte von enterotoxinen und verwandten verbindungen - Google Patents
Tumor-zerstörende effekte von enterotoxinen und verwandten verbindungenInfo
- Publication number
- DE69133068D1 DE69133068D1 DE69133068T DE69133068T DE69133068D1 DE 69133068 D1 DE69133068 D1 DE 69133068D1 DE 69133068 T DE69133068 T DE 69133068T DE 69133068 T DE69133068 T DE 69133068T DE 69133068 D1 DE69133068 D1 DE 69133068D1
- Authority
- DE
- Germany
- Prior art keywords
- enterotoxins
- related compounds
- destroying effects
- tumor destroying
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 231100000655 enterotoxin Toxicity 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000147 enterotoxin Substances 0.000 title 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
- A61K39/464821—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
- A61K39/464822—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46657790A | 1990-01-17 | 1990-01-17 | |
PCT/US1991/000342 WO1991010680A1 (en) | 1990-01-17 | 1991-01-17 | Tumor killing effects of enterotoxins and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69133068D1 true DE69133068D1 (de) | 2002-08-22 |
DE69133068T2 DE69133068T2 (de) | 2003-03-13 |
Family
ID=23852299
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69133484T Expired - Fee Related DE69133484T2 (de) | 1990-01-17 | 1991-01-17 | Verwendung von Staphylococcus-Enterotoxinen oder verwandte Verbindungen für Krebs-Therapie |
DE69133485T Expired - Lifetime DE69133485T2 (de) | 1990-01-17 | 1991-01-17 | Verwendung von Staphylococcus Enterotoxin Homologe für Krebs-Therapie |
DE69133068T Revoked DE69133068T2 (de) | 1990-01-17 | 1991-01-17 | Tumor-zerstörende effekte von enterotoxinen und verwandten verbindungen |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69133484T Expired - Fee Related DE69133484T2 (de) | 1990-01-17 | 1991-01-17 | Verwendung von Staphylococcus-Enterotoxinen oder verwandte Verbindungen für Krebs-Therapie |
DE69133485T Expired - Lifetime DE69133485T2 (de) | 1990-01-17 | 1991-01-17 | Verwendung von Staphylococcus Enterotoxin Homologe für Krebs-Therapie |
Country Status (5)
Country | Link |
---|---|
EP (3) | EP1103268B1 (de) |
AT (3) | ATE220688T1 (de) |
CA (1) | CA2078003C (de) |
DE (3) | DE69133484T2 (de) |
WO (1) | WO1991010680A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6042837A (en) * | 1989-09-20 | 2000-03-28 | Kalland; Terje | Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC) |
SE8903100D0 (sv) † | 1989-09-20 | 1989-09-20 | Pharmacia Ab | New pharmaceutical agent |
US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
US6126945A (en) * | 1989-10-03 | 2000-10-03 | Pharmacia Ab | Tumor killing effects of enterotoxins, superantigens, and related compounds |
WO1993024136A1 (en) * | 1991-01-17 | 1993-12-09 | Terman David S | Tumor killing effects of enterotoxins, superantigens, and related compounds |
US5529934A (en) * | 1991-07-29 | 1996-06-25 | Biomide Investment Limited Partnership | Method for measuring blood procoagulant activity of human leukocyte antigens |
EP0626805A4 (en) * | 1992-01-28 | 1995-12-06 | Nat Jewish Ct Immun & Respirat | Protective effects of mutated superantigens. |
AU6358994A (en) * | 1993-03-02 | 1994-09-26 | David S. Terman | Method of cancer treatment |
US5585465A (en) * | 1993-04-05 | 1996-12-17 | National Jewish Center For Immunology And Respiratory Medicine | Isolated toxin associated with Kawasaki syndrome |
SE9402430L (sv) | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
US5626838A (en) * | 1995-03-13 | 1997-05-06 | The Procter & Gamble Company | Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx |
US5935568A (en) * | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
IL119938A (en) | 1996-12-30 | 2005-08-31 | Yissum Res Dev Co | Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells |
US6075119A (en) | 1997-04-07 | 2000-06-13 | The Rockefeller University | Peptides useful for reducing symptoms of toxic shock syndrome |
US6872394B1 (en) | 1997-12-02 | 2005-03-29 | Idaho Research Foundation, Inc. | Non-toxic immune stimulating enterotoxin compositions |
EP1127132A1 (de) * | 1998-10-07 | 2001-08-29 | The Rockefeller University | Geeignete peptide zur reduzierung des toxischen schock syndroms und von septischem schock |
SE0102327D0 (sv) | 2001-06-28 | 2001-06-28 | Active Biotech Ab | A novel engineered superantigen for human therapy |
WO2018225063A1 (en) * | 2017-06-04 | 2018-12-13 | Rappaport Family Institute For Research In The Medical Sciences | Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01500905A (ja) * | 1986-10-16 | 1989-03-30 | プレジデント アンド フェロース オブ ハーバード カレッジ | 腫瘍壊死因子と抗炎症剤との組合せおよび悪性腫瘍性および非悪性腫瘍性疾患の処置方法 |
SE8801426D0 (sv) * | 1988-04-15 | 1988-04-15 | Ulf Rothman | Forfarande och medel for blodbehandling |
SE8903100D0 (sv) * | 1989-09-20 | 1989-09-20 | Pharmacia Ab | New pharmaceutical agent |
-
1991
- 1991-01-17 AT AT91903963T patent/ATE220688T1/de active
- 1991-01-17 EP EP01102715A patent/EP1103268B1/de not_active Expired - Lifetime
- 1991-01-17 DE DE69133484T patent/DE69133484T2/de not_active Expired - Fee Related
- 1991-01-17 CA CA002078003A patent/CA2078003C/en not_active Expired - Lifetime
- 1991-01-17 AT AT01104586T patent/ATE304371T1/de not_active IP Right Cessation
- 1991-01-17 AT AT01102715T patent/ATE303157T1/de not_active IP Right Cessation
- 1991-01-17 EP EP91903963A patent/EP0511306B1/de not_active Revoked
- 1991-01-17 EP EP01104586A patent/EP1129717B2/de not_active Expired - Lifetime
- 1991-01-17 WO PCT/US1991/000342 patent/WO1991010680A1/en not_active Application Discontinuation
- 1991-01-17 DE DE69133485T patent/DE69133485T2/de not_active Expired - Lifetime
- 1991-01-17 DE DE69133068T patent/DE69133068T2/de not_active Revoked
Also Published As
Publication number | Publication date |
---|---|
DE69133068T2 (de) | 2003-03-13 |
DE69133485D1 (de) | 2005-10-20 |
EP1129717A1 (de) | 2001-09-05 |
EP0511306B1 (de) | 2002-07-17 |
DE69133485T2 (de) | 2006-06-22 |
CA2078003C (en) | 2006-11-21 |
CA2078003A1 (en) | 1991-07-18 |
DE69133484T2 (de) | 2006-05-18 |
ATE304371T1 (de) | 2005-09-15 |
EP0511306A1 (de) | 1992-11-04 |
EP1129717B1 (de) | 2005-09-14 |
DE69133484D1 (de) | 2005-10-06 |
ATE220688T1 (de) | 2002-08-15 |
EP1129717B2 (de) | 2013-03-06 |
EP1103268B1 (de) | 2005-08-31 |
EP1103268A1 (de) | 2001-05-30 |
WO1991010680A1 (en) | 1991-07-25 |
ATE303157T1 (de) | 2005-09-15 |
EP0511306A4 (en) | 1993-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation |